tetano
Editor, Senior Moderator
Virol Sin. 2019 Oct 21. doi: 10.1007/s12250-019-00161-w. [Epub ahead of print] [h=1]Spatial, Temporal and Genetic Dynamics Characteristics of Influenza B Viruses in China, 1973-2018.[/h]
Li X[SUP]1,[/SUP][SUP]2[/SUP], Chan KKY[SUP]1,[/SUP][SUP]2[/SUP], Xu B[SUP]1,[/SUP][SUP]2[/SUP], Lu M[SUP]3[/SUP], Xu B[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h] 1 Department of Earth System Science, Tsinghua University, Beijing, 100084, China. 2 Center for Healthy Cities, Institute for China Sustainable Urbanization, Tsinghua University, Beijing, 100084, China. 3 State Key Laboratory of Resources and Environment Information System, Institute of Geographical Science and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China. 4 Department of Earth System Science, Tsinghua University, Beijing, 100084, China. bingxu@tsinghua.edu.cn. 5 Center for Healthy Cities, Institute for China Sustainable Urbanization, Tsinghua University, Beijing, 100084, China. bingxu@tsinghua.edu.cn.
[h=3]Abstract[/h] Annual influenza B virus epidemics and outbreaks cause severe influenza diseases in humans and pose a threat to public health. China is an important epidemic area of influenza B viruses. However, the spatial, temporal transmission pathways and the demography history of influenza B viruses in China remain unknown. We collected the haemagglutinin gene sequences sampled of influenza B virus in China between 1973 and 2018. A Bayesian Markov chain Monte Carlo phylogeographic discrete approach was used to infer the spatial and temporal phylodynamics of influenza B virus. The Bayesian phylogeographic analysis of influenza B viruses showed that the North subtropical and South subtropical zones are the origins of the Victoria and Yamagata lineage viruses, respectively. Furthermore, the South temperate and North subtropical zones acted as transition nodes in the Victoria lineage virus dispersion network and that the North subtropical and Mid subtropical zones acted as transition nodes in the Yamagata lineage virus dispersion network. Our findings contribute to the knowledge regarding the spatial and temporal patterns of influenza B virus outbreaks in China.
[h=4]KEYWORDS:[/h] Effective population size; Influenza B viruses; Mainland China; Phylogeographic; Spatial dispersion
PMID: 31637629 DOI: 10.1007/s12250-019-00161-w
Li X[SUP]1,[/SUP][SUP]2[/SUP], Chan KKY[SUP]1,[/SUP][SUP]2[/SUP], Xu B[SUP]1,[/SUP][SUP]2[/SUP], Lu M[SUP]3[/SUP], Xu B[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h] 1 Department of Earth System Science, Tsinghua University, Beijing, 100084, China. 2 Center for Healthy Cities, Institute for China Sustainable Urbanization, Tsinghua University, Beijing, 100084, China. 3 State Key Laboratory of Resources and Environment Information System, Institute of Geographical Science and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China. 4 Department of Earth System Science, Tsinghua University, Beijing, 100084, China. bingxu@tsinghua.edu.cn. 5 Center for Healthy Cities, Institute for China Sustainable Urbanization, Tsinghua University, Beijing, 100084, China. bingxu@tsinghua.edu.cn.
[h=3]Abstract[/h] Annual influenza B virus epidemics and outbreaks cause severe influenza diseases in humans and pose a threat to public health. China is an important epidemic area of influenza B viruses. However, the spatial, temporal transmission pathways and the demography history of influenza B viruses in China remain unknown. We collected the haemagglutinin gene sequences sampled of influenza B virus in China between 1973 and 2018. A Bayesian Markov chain Monte Carlo phylogeographic discrete approach was used to infer the spatial and temporal phylodynamics of influenza B virus. The Bayesian phylogeographic analysis of influenza B viruses showed that the North subtropical and South subtropical zones are the origins of the Victoria and Yamagata lineage viruses, respectively. Furthermore, the South temperate and North subtropical zones acted as transition nodes in the Victoria lineage virus dispersion network and that the North subtropical and Mid subtropical zones acted as transition nodes in the Yamagata lineage virus dispersion network. Our findings contribute to the knowledge regarding the spatial and temporal patterns of influenza B virus outbreaks in China.
[h=4]KEYWORDS:[/h] Effective population size; Influenza B viruses; Mainland China; Phylogeographic; Spatial dispersion
PMID: 31637629 DOI: 10.1007/s12250-019-00161-w