Spain: Second death from H1N1 virus mutation in our country

[estacion]

Segunda muerte por mutaci?n del virus H1N1 en nuestro pa?s
Primera muerte en Espa?a a causa de una mutaci?n de la gripe A
Detectados m?s de 40 casos de mutaciones del virus H1N1 en Espa?a


EP | MADRID/SEVILLA Actualizado Lunes , 04-01-10 a las 17 : 50
Un hombre de 31 a?os ha fallecido en Andaluc?a por complicaciones derivadas de una mutaci?n del virus de la gripe A, la 'D222G', convirti?ndose as? en la primera muerte en Andaluc?a -segunda en Espa?a- por esta alteraci?n del virus A/H1N1 detectada por vez primera en Noruega, seg?n revela el ?ltimo informe semanal la Red Nacional de Vigilancia Epidemiol?gica del Instituto de Salud Carlos III.

Este paciente, que no presentaba antecedentes m?dicos, ha fallecido por un fallo multiorg?nico despu?s de varias complicaciones, informa el sistema de vigilancia por M?dicos Centinela, que sin embargo no precisa el momento del fallecimiento.
No obstante, fuentes del Ministerio de Sanidad y Pol?tica Social consultadas aseguran que esta mutaci?n es "esperable", en funci?n del comportamiento que cada a?o tienen los virus de la gripe.

Esta mutaci?n ha sido detectada en otros pa?ses del mundo y, aunque su significaci?n no est? del todo definida, podr?a favorecer que el virus tuviera "m?s facilidad para infectar zonas m?s inferiores del tracto respiratorio", informa la Red de Vigilancia en su ?ltimo informe, relativo a la semana del 20 al 26 de diciembre.

La primera v?ctima mortal por esta mutaci?n fue anunciada por el director general de Salud P?blica y Sanidad Exterior, Ildefonso Hern?ndez, el pasado 4 de diciembre, detect?ndose en una mujer de 35 de Catalu?a con patolog?as asociadas que acab? falleciendo tras estar en estado grave.

Adem?s, a estos dos fallecimientos hay que a?adir tres casos m?s de esta misma mutaci?n del virus A/H1N1: una en un hombre de 31 a?os de Catalu?a, que evolucion? sin problemas; una en Castilla-La Mancha en una mujer de 28 a?os y otra en Galicia en un hombre de 27 a?os, estos dos ?ltimos sin conocimiento de factores de riesgo y su posterior evoluci?n.

Dicha mutaci?n del ARN afecta a la cubierta del virus en un lugar pr?ximo al punto de uni?n del receptor a la c?lula del epitelio bronquial y, aunque "la significaci?n de este cambio en el sitio de uni?n al receptor es muy dudosa", explican los autores del informe, "los datos de los pacientes que la presentan pueden ser de gran ayuda para tratar de interpretar si tiene alguna funcionalidad".

Fuente: ABC
http://www.abc.es/20100104/sociedad-gripe-a/segunda-muerte-mutacion-virus-201001041731.html



Second death from H1N1 virus mutation in our country
First death in Spain due to a mutation of the influenza A
Identified over 40 cases of mutations of the H1N1 virus in Spain


EP | MADRID / SEVILLE Updated Monday, 04-01-10 at 17: 50
A man aged 31 has died in Andalusia by complications from a mutation of the influenza virus A, 'D222G', becoming the first death in Andalusia, second in Spain, for this alteration detected H1N1 virus first time in Norway, as the latest weekly report from the National Epidemiological Surveillance Network of the Instituto de Salud Carlos III.

This patient, who had no medical history, has died of multiple organ failure after several complications, reports the monitoring system sentinel physicians, which however does not specify the time of death.

However, sources with the Ministry of Health and Social Policy consulted confirmed that this mutation is "expected" in terms of behavior that have extensive Web influenza viruses.

This mutation has been detected in other countries around the world, although its significance is not fully defined, could enhance the virus would "infect it easier to lower areas of the respiratory tract, the Surveillance Network reported in its latest report, on the week of 20 to 26 December.

The first fatality in this mutation was announced by the director general of Health and Foreign Health, Ildefonso Hernandez, on 4 December, detected in a 35 yrs-old woman in Catalonia with associated pathologies that eventually died after being in serious condition.

Moreover, these two deaths have to add three more cases of this same mutation in the H1N1 virus, one in a man of 31 years of Catalonia, which evolved without problems, one in Castilla-La Mancha in a woman of 28 years and another in Galicia in a man of 27 years, the last two without knowledge of risk factors and their subsequent evolution.

The mutation of RNA affects the viral envelope in a place near the junction of the receiver to the bronchial epithelial cell, although "the significance of this change in the receptor-binding site is highly questionable," the authors explain the report, "data from patients who have can be very helpful in trying to interpret if you have any functionality."

Source: ABC
http://translate.google.es/translat...-mutacion-virus-201001041731.html&sl=es&tl=en

 

[Celvin11]

Re: Spain: Second death from H1N1 virus mutation in our country

It seems there are reasons not to close down information from Spain

 

[Tonka]

Re: Spain: Second death from H1N1 virus mutation in our country

http://www.elpais.com/articulo/salu...ndalucia/elpepusocsal/20100105elpepisal_1/Tes

One died from the H1N1 mutation in Andalusia
COUNTRY - Madrid - 05/01/2010


A man aged 31 died in Andalusia by complications of D222G, a mutation of the influenza virus A. It is the second died in Spain by this alteration of H1N1. A mutation that has already caused other deaths in countries like Norway, where it was first detected last month and a half, or Holland. Data from the National Epidemiological Surveillance Network of the Instituto de Salud Carlos III, the reference center of flu, revealed that the deceased had no medical history and who died of multiple organ failure.


The authorities are still analyzing the mutation of H1N1 is now located in Andalusia. Experts from the Carlos III argue that the change could encourage the virus to infect more easily find the lower areas of the respiratory tract. Last month it was detected the first fatality in the D222G mutation in Spain. It was a 35 year old woman who died in Catalonia. Furthermore, the alteration of the virus was detected in three other people in Spain have managed to recover after being admitted serious.

Apart from the mutation, H1N1 has claimed 247 lives in Spain. The peak of the pandemic and has already submitted, however, the vaccination campaign is not over yet. Health is now looking, as the minister reiterated Trinidad Jimenez, what to do with leftover vaccine. Of the 13 million served by the laboratories (bought 37, but it was agreed not to send all) were only used two. Thus, Jimenez said, the doses are not used could be sold to other EU countries like Poland or Bulgaria, or donated to developing countries. A formula is also studying the U.S..

 

[estacion]

Re: Spain: Second death from H1N1 virus mutation in our country

http://www.elpais.com/articulo/salu...ndalucia/elpepusocsal/20100105elpepisal_1/Tes

One died from the H1N1 mutation in Andalusia
COUNTRY - Madrid - 05/01/2010


A man aged 31 died in Andalusia by complications of D222G, a mutation of the influenza virus A......

Apart from the mutation, H1N1 has claimed 247 lives in Spain. The peak of the pandemic and has already submitted, however, the vaccination campaign is not over yet. Health is now looking, as the minister reiterated Trinidad Jimenez, what to do with leftover vaccine. Of the 13 million served by the laboratories (bought 37, but it was agreed not to send all) were only used two. Thus, Jimenez said, the doses are not used could be sold to other EU countries like Poland or Bulgaria, or donated to developing countries. A formula is also studying the U.S..

This news has a typo, there are known 274 deaths at Spain right now.

 

[Tonka]

Re: Spain: Second death from H1N1 virus mutation in our country

http://www.que.es/sevilla/201001081241-tasa-h1n1-sufre-leve-repunte.html

The rate of H1N1 undergoes a slight rise, to stand at 63 cases per 100,000, and two mutations are reported more
January 8, 2010.
Discuss The rate of influenza Andalusian experienced in the last week of analysis, between 27 December and 2 January, a slight upturn in cases, now located in 63 affected per 100,000 inhabitants, compared to 51 infections per 100,000 from the week prior, thereby interrupting the downward trend in the H1N1 virus activity in the community, which had come to collect consecutive declines in the last five weeks of analysis.

SEVILLE, 8 (EUROPA PRESS)


The rate of influenza Andalusian experienced in the last week of analysis, between 27 December and 2 January, a slight upturn in cases, now located in 63 affected per 100,000 inhabitants, compared to 51 infections per 100,000 the week prior, thereby interrupting the downward trend in the H1N1 virus activity in the community, which had come to collect consecutive declines in the last five weeks of analysis.


It is clear from the data provided in the network for epidemiological surveillance of influenza in Spain, after inquiries by Europa Press, the Andalusian community has registered two cases of D222G mutation, which are now three cases of the type found in Andalusia .

This mutation has already prompted a man aged 31 dies in Andalusia from complications arising therefrom, thus becoming the first death in Andalusia and the second in Spain after a case in Catalonia, as previously reported by Europa Press.


So far Spain have been detected in ten cases with the D222G mutation. Three of them have occurred in Andalusia, three in the Basque Country, two in Catalonia, one in Castilla La Mancha and one in Galicia.
This mutation has already been detected elsewhere in the world and although its significance is not fully defined, could enhance the virus would "infect it easier to lower areas of the respiratory tract.


COMPARISON BY COMMUNITIES


Based on their comparative communities, the rate of Andalusia, still low, is the second highest state level, second only to the Canaries, with 113.31 cases per 100,000 people. In any case, the surveillance network refers to a level of dissemination Andalusia "sporadic" and current "low" of the virus.


Globally, the average incidence rate in Spain for the last week is 37.50 cases per 100,000 population. Therefore, the incidence rate of influenza A is below the threshold value for the 2009-2010 season for the second straight week. In fact, this week continues the gradual decline in the rate of viral detection (10%) which has suffered since week 43/2009 (68%).


Regarding the incidence of recorded po flu age groups in Spain, they are "similar" in all age cohorts for the previous week of surveillance, where the level of dissemination "local" and "low" intensity

 

[Tonka]

Re: Spain: Second death from H1N1 virus mutation in our country

http://www.melillahoy.es/noticia/61...detectado-pacientes-mutación-virus-gripe.html

In Melilla have also detected a mutation in patients with influenza A virus

Maria Antonia Garbin, advisor on Social Welfare and Health

J.A. / E.P.
Last updated 07/01/2010 @ 00:51:26 GMT +1
The National Epidemiological Surveillance Center of the Health Institute Carlos III reports that have already been registered in Spain more than 40 cases of mutations of the H1N1 virus that causes influenza, among which would be the "D222E", which has found its presence in 34 patients from Castilla-La Mancha, Ceuta, Galicia, Madrid, Melilla and Navarra. In addition, Andalusia and Asturias have identified in 6 and 1 cases respectively. In Melilla have been vaccinated only two thousand people, despite being available over twelve thousand doses.

Councilor Welfare and Health, Maria Antonia Garbin, said the vaccination campaign against influenza A is doing "evil", and this is because even though it gained about twelve thousand doses have been distributed at health centers and insurance, just "two thousand people have been vaccinated. The figures are below the norm in the rest of the country.

Considers that one of the causes that are not vaccinated Melilla and also a decline in the number of infections, high temperatures are still found in Melilla. In fact according to the National Epidemiological Surveillance of the Health Institute Carlos III, the reported incidence rate of influenza is in Melilla in 28.18 cases per 100,000 population, below the national average which is 40.8 cases .

But Garb?n said that we must not drop our guard, because from now is expected to reach the winter weather will cause an increase in flu cases. "We will continue the campaign until being told otherwise by health authorities.

A journalists' questions, said Garb?n not yet decided what to do with leftover doses, and that decision will be adopted in the relevant body in Madrid with the participation of all communities. One solution that has considered is to send low-income countries. What is certain is that these vaccines will no longer be operational next year, driven by the mutation that is prone to the flu virus, both A and B.

Recognized Garb?n have been detected in our country mutations of H1N1 (influenza virus) that are being analyzed by the Carlos III Institute, without which for the moment had been issued special rules to follow.

Mutations
Just this week a man aged 31 died in Andalusia from complications from a mutation of the influenza virus A, "D222G", becoming the second death in Spain by this alteration of the H1N1 virus first detected in Norway According to the latest weekly report from the National Epidemiological Surveillance Network.

This patient, who had no medical history, eventually dying of multiple organ failure after several complications, reports the monitoring system by Sentinel Physicians. However, Health Ministry sources claimed that this mutation is "expected" behavior according to each year have the flu virus.

This mutation has been detected in other countries and, although its significance is not fully defined, could enhance the virus would "infect it easier to lower areas of the respiratory tract, the Surveillance Network reported in its latest report.

In addition, the National Epidemiological Surveillance Network reported more than 40 mutations of "D222E" and that his presence was found in about 34 patients from the regions of Castilla-La Mancha, Ceuta, Galicia, Madrid, Melilla and Navarra.