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Siberian scientists are working to cure smallpox
April 5, 2012
According to an official statement of the World Health Organization Smallpox was eradicated in 1980. However, the danger remains. That is why in the world do not stop searching for effective drugs.
One of them - NIOC-14 - developed by scientists of the Novosibirsk Institute of Organic Chemistry. NNVorozhtsov together with specialists from the State Research Center of Virology and Biotechnology "Vector." Of course, smallpox has not returned - but it can. WHO has decided to leave the store in the world two strains of the virus: here, in "Vector" and the U.S. . . .
Our research has been conducted since the year 2008, - said Larissa Shishkin - and all the world looking for drugs engaged for several decades. In the U.S., was created by ST-246, and we asked the Institute of Organic Chemistry SB RAS with a request to repeat its synthesis. Then another problem arose: to try to obtain analogues of the drug, but those that could be patented in Russia and the world.
The more we come to our chemical compound on the one hand by accident, but on the other - deliberately - says senior researcher Institute of Organic Chemistry SB RAS Ph.D. Boris Selivanov - we walked all the chemists, who used to synthesize ST-246: the Americans, and other research groups. Our product - a fully chemical synthesis from commercially available compounds. First, the initial results in two, and then they are "stitched" together by mixing. The resulting interaction of the substance falls from poorly soluble precipitate, which we separate, dry them and give the test.
According to the scientist to understand what a fragment of the molecule responsible for the antiviral effect, we must have all the diversity of the structures of these compounds to see how changing the design affect the biological activity of the drug. You must synthesize many substances, and the experts 'Vector' to explore them. First tests carried out on cell culture: it is infected with vaccinia virus (it is similar to smallpox), and then added to the test drug. . . .
http://sibkray.ru/news/7/327450/
Siberian scientists are working to cure smallpox
April 5, 2012
According to an official statement of the World Health Organization Smallpox was eradicated in 1980. However, the danger remains. That is why in the world do not stop searching for effective drugs.
One of them - NIOC-14 - developed by scientists of the Novosibirsk Institute of Organic Chemistry. NNVorozhtsov together with specialists from the State Research Center of Virology and Biotechnology "Vector." Of course, smallpox has not returned - but it can. WHO has decided to leave the store in the world two strains of the virus: here, in "Vector" and the U.S. . . .
Our research has been conducted since the year 2008, - said Larissa Shishkin - and all the world looking for drugs engaged for several decades. In the U.S., was created by ST-246, and we asked the Institute of Organic Chemistry SB RAS with a request to repeat its synthesis. Then another problem arose: to try to obtain analogues of the drug, but those that could be patented in Russia and the world.
The more we come to our chemical compound on the one hand by accident, but on the other - deliberately - says senior researcher Institute of Organic Chemistry SB RAS Ph.D. Boris Selivanov - we walked all the chemists, who used to synthesize ST-246: the Americans, and other research groups. Our product - a fully chemical synthesis from commercially available compounds. First, the initial results in two, and then they are "stitched" together by mixing. The resulting interaction of the substance falls from poorly soluble precipitate, which we separate, dry them and give the test.
According to the scientist to understand what a fragment of the molecule responsible for the antiviral effect, we must have all the diversity of the structures of these compounds to see how changing the design affect the biological activity of the drug. You must synthesize many substances, and the experts 'Vector' to explore them. First tests carried out on cell culture: it is infected with vaccinia virus (it is similar to smallpox), and then added to the test drug. . . .
http://sibkray.ru/news/7/327450/