tetano
Editor, Senior Moderator
Front Microbiol. 2016 Jun 15;7:924. doi: 10.3389/fmicb.2016.00924. eCollection 2016.
[h=1]Short-Term Heat Shock Affects Host-Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1.[/h] Xue J[SUP]1[/SUP], Fan X[SUP]2[/SUP], Yu J[SUP]3[/SUP], Zhang S[SUP]4[/SUP], Xiao J[SUP]5[/SUP], Hu Y[SUP]1[/SUP], Wang M[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Highly pathogenic avian influenza virus (HPAIV) H5N1 is a highly contagious virus that can cause acute respiratory infections and high human fatality ratio due to excessive inflammatory response. Short-term heat shock, as a stressful condition, could induce the expression of heat shock proteins that function as molecular chaperones to protect cells against multiple stresses. However, the protective effect of short-term heat shock in influenza infection is far from being understood. In this study, mice were treated at 39?C for 4 h before being infected with HPAIV H5N1. Interestingly, short-term heat shock significantly increased the levels of HSP70 and pro-inflammatory cytokines IL-6, TNF-α, IFN-β, and IFN-γ in the lung tissues of mice. Following HPAIV H5N1 infection, short-term heat shock alleviated immunopathology and viral replication in lung tissue and repressed the weight loss and increased the survival rate of H5N1-infected mice. Our data reported that short-term heat shock provided beneficial anti-HPAIV H5N1 properties in mice model, which offers an alternative strategy for non-drug prevention for influenza infection.
[h=4]KEYWORDS:[/h] HSP70; cytokine; heat shock response; influenza A virus; short-term heat short
PMID: 27379054 PMCID: PMC4908103 DOI: 10.3389/fmicb.2016.00924
[PubMed]
[h=1]Short-Term Heat Shock Affects Host-Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1.[/h] Xue J[SUP]1[/SUP], Fan X[SUP]2[/SUP], Yu J[SUP]3[/SUP], Zhang S[SUP]4[/SUP], Xiao J[SUP]5[/SUP], Hu Y[SUP]1[/SUP], Wang M[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Highly pathogenic avian influenza virus (HPAIV) H5N1 is a highly contagious virus that can cause acute respiratory infections and high human fatality ratio due to excessive inflammatory response. Short-term heat shock, as a stressful condition, could induce the expression of heat shock proteins that function as molecular chaperones to protect cells against multiple stresses. However, the protective effect of short-term heat shock in influenza infection is far from being understood. In this study, mice were treated at 39?C for 4 h before being infected with HPAIV H5N1. Interestingly, short-term heat shock significantly increased the levels of HSP70 and pro-inflammatory cytokines IL-6, TNF-α, IFN-β, and IFN-γ in the lung tissues of mice. Following HPAIV H5N1 infection, short-term heat shock alleviated immunopathology and viral replication in lung tissue and repressed the weight loss and increased the survival rate of H5N1-infected mice. Our data reported that short-term heat shock provided beneficial anti-HPAIV H5N1 properties in mice model, which offers an alternative strategy for non-drug prevention for influenza infection.
[h=4]KEYWORDS:[/h] HSP70; cytokine; heat shock response; influenza A virus; short-term heat short
PMID: 27379054 PMCID: PMC4908103 DOI: 10.3389/fmicb.2016.00924
[PubMed]