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Shaping immune development in utero

M

Mary Wilson

Well-known member
PERSPECTIVES

10.1126/science.abl3631

Fetal immune development is sensitive to changes in the dam, including gut microbiota, diet, and inflammation, such as from vaccination. A mild, maternally restricted infection may lead to interleukin-6 (IL-6)–induced epigenetic imprinting in fetal intestinal epithelium and intestinal T helper 17 (TH 17)
cells in adult offspring. As a result, the adult offspring have enhanced immunity against enteric pathogens

http://science.sciencemag.org/content/sci/373/6558/968.full.pdf
 
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