tetano
Editor, Senior Moderator
Front Immunol. 2019 Feb 27;10:180. doi: 10.3389/fimmu.2019.00180. eCollection 2019.
[h=1]Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination.[/h] Voigt EA[SUP]1[/SUP], Ovsyannikova IG[SUP]1[/SUP], Kennedy RB[SUP]1[/SUP], Grill DE[SUP]2[/SUP], Goergen KM[SUP]2[/SUP], Schaid DJ[SUP]2[/SUP], Poland GA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immunization with the 2010/11 seasonal inactivated influenza vaccine. Results: We identified higher B-cell ELISPOT responses in females than males. Potential mechanisms for sex effects were identified in four gene clusters related to T, NK, and B cells. Mediation analysis indicated that sex-dependent expression in T and NK cell genes can be partially attributed to higher CD4+ T cell and lower NK cell fractions in females. We identified strong sex effects in 135 B cell genes whose expression correlates with ELISPOT measures, and found that cell subset differences did not explain the effect of sex on these genes' expression. Post-vaccination expression of these genes, however, mediated 41% of the sex effect on ELISPOT responses. Conclusions: These results improve our understanding of sexual dimorphism in immunity and influenza vaccine response.
[h=4]KEYWORDS:[/h] elderly; immunity; influenza; influenza vaccine; sex differences; sexual dimorphism; systems biology; vaccinomics
PMID: 30873150 PMCID: PMC6400991 DOI: 10.3389/fimmu.2019.00180
[h=1]Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination.[/h] Voigt EA[SUP]1[/SUP], Ovsyannikova IG[SUP]1[/SUP], Kennedy RB[SUP]1[/SUP], Grill DE[SUP]2[/SUP], Goergen KM[SUP]2[/SUP], Schaid DJ[SUP]2[/SUP], Poland GA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immunization with the 2010/11 seasonal inactivated influenza vaccine. Results: We identified higher B-cell ELISPOT responses in females than males. Potential mechanisms for sex effects were identified in four gene clusters related to T, NK, and B cells. Mediation analysis indicated that sex-dependent expression in T and NK cell genes can be partially attributed to higher CD4+ T cell and lower NK cell fractions in females. We identified strong sex effects in 135 B cell genes whose expression correlates with ELISPOT measures, and found that cell subset differences did not explain the effect of sex on these genes' expression. Post-vaccination expression of these genes, however, mediated 41% of the sex effect on ELISPOT responses. Conclusions: These results improve our understanding of sexual dimorphism in immunity and influenza vaccine response.
[h=4]KEYWORDS:[/h] elderly; immunity; influenza; influenza vaccine; sex differences; sexual dimorphism; systems biology; vaccinomics
PMID: 30873150 PMCID: PMC6400991 DOI: 10.3389/fimmu.2019.00180