tetano
Editor, Senior Moderator
Virology. 2014 Jan 5;448:74-81. doi: 10.1016/j.virol.2013.10.001. Epub 2013 Oct 20.
Severe pathogenesis of influenza B virus in pregnant mice.
Kim JC, Kim HM, Kang YM, Ku KB, Park EH, Yum J, Kim JA, Kang YK, Lee JS, Kim HS, Seo SH.
Source
Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Republic of Korea; Institute for Influenza Virus, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Republic of Korea.
Abstract
The study on pathogenesis of influenza B virus during pregnancy is limited. Here, we showed using a mouse model that influenza B virus could cause severe disease including death during pregnancy. Infected pregnant mice resulted in 40% mortality, but infected age-matched non-pregnant mice did not show any death. Infected pregnant mice contained high viral loads in lungs with the elevated inductions of inflammatory cytokines and chemokines than infected non-pregnant mice. Infected pregnant mice delivered lower number of neonates than uninfected pregnant mice, suggesting adverse effects of influenza B virus on fetuses. Progesterone which is important for maintaining pregnancy was reduced in uteruses of infected pregnant mice than in those of uninfected pregnant mice. Taken together, our results suggest that influenza B virus can cause severe disease during pregnancy, and that preventive measures including vaccination may be important for protecting women during pregnancy.
? 2013 Elsevier Inc. All rights reserved.
KEYWORDS:
Chemokine, Cytokine, Hormone, Influenza B virus, Pneumonia, Pregnancy
PMID:
24314638
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24314638
Severe pathogenesis of influenza B virus in pregnant mice.
Kim JC, Kim HM, Kang YM, Ku KB, Park EH, Yum J, Kim JA, Kang YK, Lee JS, Kim HS, Seo SH.
Source
Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Republic of Korea; Institute for Influenza Virus, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Republic of Korea.
Abstract
The study on pathogenesis of influenza B virus during pregnancy is limited. Here, we showed using a mouse model that influenza B virus could cause severe disease including death during pregnancy. Infected pregnant mice resulted in 40% mortality, but infected age-matched non-pregnant mice did not show any death. Infected pregnant mice contained high viral loads in lungs with the elevated inductions of inflammatory cytokines and chemokines than infected non-pregnant mice. Infected pregnant mice delivered lower number of neonates than uninfected pregnant mice, suggesting adverse effects of influenza B virus on fetuses. Progesterone which is important for maintaining pregnancy was reduced in uteruses of infected pregnant mice than in those of uninfected pregnant mice. Taken together, our results suggest that influenza B virus can cause severe disease during pregnancy, and that preventive measures including vaccination may be important for protecting women during pregnancy.
? 2013 Elsevier Inc. All rights reserved.
KEYWORDS:
Chemokine, Cytokine, Hormone, Influenza B virus, Pneumonia, Pregnancy
PMID:
24314638
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24314638