tetano
Editor, Senior Moderator
J Infect Dis. 2015 Feb 23. pii: jiv100. [Epub ahead of print]
[h=1]Severe acute respiratory illness deaths in Sub-Saharan Africa and the role of influenza: a case-series from 8 countries.[/h] McMorrow ML[SUP]1[/SUP], Wemakoy EO[SUP]2[/SUP], Tshilobo JK[SUP]3[/SUP], Emukule GO[SUP]4[/SUP], Mott JA[SUP]5[/SUP], Njuguna H[SUP]4[/SUP], Waiboci L[SUP]4[/SUP], Heraud JM[SUP]6[/SUP], Rajatonirina S[SUP]6[/SUP], Razanajatovo NH[SUP]6[/SUP], Chilombe M[SUP]7[/SUP], Everett D[SUP]7[/SUP], Heyderman RS[SUP]7[/SUP], Barakat A[SUP]8[/SUP], Nyatanyi T[SUP]9[/SUP], Rukelibuga J[SUP]10[/SUP], Cohen AL[SUP]11[/SUP], Cohen C[SUP]12[/SUP], Tempia S[SUP]13[/SUP], Thomas J[SUP]14[/SUP], Venter M[SUP]15[/SUP], Mwakapeje E[SUP]16[/SUP], Mponela M[SUP]17[/SUP], Lutwama J[SUP]18[/SUP], Duque J[SUP]19[/SUP], Lafond K[SUP]20[/SUP], Nzussouo NT[SUP]20[/SUP], Williams T[SUP]20[/SUP], Widdowson MA[SUP]20[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Data on causes of respiratory deaths in Africa are limited.
[h=4]METHODS:[/h] From January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI) deaths identified from influenza surveillance during 2009 - 2012.
[h=4]RESULTS:[/h] Twenty-three (82%) countries responded, 11 (48%) collect mortality data, and 8 provided data. Data were collected from 37,714 SARI cases and 3091 (8.2%, range by country 5.1-25.9%) tested positive for influenza. There were 1073 (2.8%, range by country 0.1-5.3%) deaths reported among whom 57 (5.3%) were influenza-positive. Case fatality proportion (CFP) was higher among countries with systematic death reporting than those with sporadic reporting. The influenza-associated CFP was 1.8% (57/3091) compared to 2.9% (1016/34,623) for influenza-negative cases (p<0.001). Among 834 (77.7%) deaths tested for other respiratory pathogens, rhinovirus (n=107, 12.8%), adenovirus (n=64, 6.0%), respiratory syncytial virus (n=60, 5.6%), and S. pneumoniae (n=57, 5.3%) were most commonly identified. Among 1073 deaths, 402 (37.5%) were aged 0-4 years, 462 (43.1%) aged 5-49 years, and 209 (19.5%) aged 50 years and older.
[h=4]CONCLUSIONS:[/h] Few African countries systematically collect data on respiratory hospitalization outcomes. Stronger surveillance for respiratory deaths may identify risk groups for targeted vaccine use and other prevention strategies.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 25712970 [PubMed - as supplied by publisher]
[h=1]Severe acute respiratory illness deaths in Sub-Saharan Africa and the role of influenza: a case-series from 8 countries.[/h] McMorrow ML[SUP]1[/SUP], Wemakoy EO[SUP]2[/SUP], Tshilobo JK[SUP]3[/SUP], Emukule GO[SUP]4[/SUP], Mott JA[SUP]5[/SUP], Njuguna H[SUP]4[/SUP], Waiboci L[SUP]4[/SUP], Heraud JM[SUP]6[/SUP], Rajatonirina S[SUP]6[/SUP], Razanajatovo NH[SUP]6[/SUP], Chilombe M[SUP]7[/SUP], Everett D[SUP]7[/SUP], Heyderman RS[SUP]7[/SUP], Barakat A[SUP]8[/SUP], Nyatanyi T[SUP]9[/SUP], Rukelibuga J[SUP]10[/SUP], Cohen AL[SUP]11[/SUP], Cohen C[SUP]12[/SUP], Tempia S[SUP]13[/SUP], Thomas J[SUP]14[/SUP], Venter M[SUP]15[/SUP], Mwakapeje E[SUP]16[/SUP], Mponela M[SUP]17[/SUP], Lutwama J[SUP]18[/SUP], Duque J[SUP]19[/SUP], Lafond K[SUP]20[/SUP], Nzussouo NT[SUP]20[/SUP], Williams T[SUP]20[/SUP], Widdowson MA[SUP]20[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Data on causes of respiratory deaths in Africa are limited.
[h=4]METHODS:[/h] From January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI) deaths identified from influenza surveillance during 2009 - 2012.
[h=4]RESULTS:[/h] Twenty-three (82%) countries responded, 11 (48%) collect mortality data, and 8 provided data. Data were collected from 37,714 SARI cases and 3091 (8.2%, range by country 5.1-25.9%) tested positive for influenza. There were 1073 (2.8%, range by country 0.1-5.3%) deaths reported among whom 57 (5.3%) were influenza-positive. Case fatality proportion (CFP) was higher among countries with systematic death reporting than those with sporadic reporting. The influenza-associated CFP was 1.8% (57/3091) compared to 2.9% (1016/34,623) for influenza-negative cases (p<0.001). Among 834 (77.7%) deaths tested for other respiratory pathogens, rhinovirus (n=107, 12.8%), adenovirus (n=64, 6.0%), respiratory syncytial virus (n=60, 5.6%), and S. pneumoniae (n=57, 5.3%) were most commonly identified. Among 1073 deaths, 402 (37.5%) were aged 0-4 years, 462 (43.1%) aged 5-49 years, and 209 (19.5%) aged 50 years and older.
[h=4]CONCLUSIONS:[/h] Few African countries systematically collect data on respiratory hospitalization outcomes. Stronger surveillance for respiratory deaths may identify risk groups for targeted vaccine use and other prevention strategies.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 25712970 [PubMed - as supplied by publisher]