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SEVERAL CASES OF FATAL ILLNESS , NOVEL ARENAVIRUS STRAIN? - SOUTH AFRICA ex ZAMBIA

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

[Now I am not sure what hospital the nanny and son are at....note comment further up on this thread.]

-snip-
Response teams are monitoring them closely.
Mthembu?s 11-year-old son and his 28-year-old nanny are being kept in isolation at the Morningside hospital, although they have not shown symptoms of the disease.

http://www.thetimes.co.za/News/Article.aspx?id=858408
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

?No more cases of mystery disease?
Published: 10/8/2008 08:14:13


GAYNOR NOYCE
JOHANNESBURG - Wilderness Safaris in Zambia said they were deeply saddened by the death of their employee, Cecilia van Deventer, and the related deaths which seem to be the result of contact with bodily fluids.
Chairman Malcolm McCulloch said he had appointed Dr Simon King to provide expert advice regarding the current situation. King is presently liaising with Professors Swannepoel and Blumberg, who are leading authorities on communicable diseases.
?Our 18 staff in the Lusaka office and four in the Johannesburg office who have been in direct contact with Cecilia have all passed the critical 14-day period without showing symptoms of the same illness,? McCulloch said.
Medical specialists are confident this is not an outbreak, but rather an isolated incident, given the relatively isolated nature of events.
The Zambian ministry of heath said there had been no more cases reported in Zambia yesterday. All travellers are advised the situation is normal.

?We are confident all of our Zambian camps are free from any effects of this disease. This has never happened in the history of the company,? McCulloch said.:tiphat:
http://www.citizen.co.za/index/article.aspx?pDesc=79568,1,22
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

We are containing virus: MEC
Published: 10/8/2008 08:12:03


CHRIS BATHEMBU
JOHANNESBURG - Gauteng Health MEC Brian Hlongwa said authorities ensured that the mysterious virus, that claimed three lives in Johannesburg, was brought under control.
Hlongwa yesterday said: ?We have been addressing the issue, trying to get all the information.
?We have moved with speed and have brought in the National Institute of Infectious Diseases to assist?.
He said everyone who had contact with the Zambian patient, believed to be the fever?s source, had been contacted to contain the virus.
The MEC said a report was expected in the next 10 days.
Tests are being conducted here and in Atlanta.
Relatives of the people who died are being monitored. :tiphat:
http://www.citizen.co.za/index/article.aspx?pDesc=79561,1,22
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

<TABLE xmlns:fo="http://www.w3.org/1999/XSL/Format"><TBODY><TR><TD class=ArticleHead colSpan=2>Virus: Food-poisoning claim<!--head0--></TD></TR><TR><TD class=Byline><!--byline1-->Borrie La Grange<!--byline0--></TD><TD class=Published align=right>Published:<!--date1-->Oct 09, 2008<!--date0--></TD></TR><TR><TD class=ArticleHead colSpan=2><HR class=ArticleLine width="100%" SIZE=1></TD></TR><TR><TD colSpan=2><TABLE cellSpacing=0 cellPadding=5 width=200 align=right border=0><TBODY><TR><TD><TABLE cellSpacing=0 cellPadding=0 width=200 border=0><TBODY><TR><TD class=ArticleImg><TABLE cellSpacing=0 cellPadding=0 width=200 align=right border=0><TBODY><TR><TD class=storybody width=200>
quoteline.gif

quotestart.gif
Additional infection had a role
quoteend.gif
quoteline.gif
</TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></TD></TR><TR><TD><TABLE width=200><TBODY><TR><TD class=RelatedLinksTitle style="FONT-WEIGHT: bold"></TD></TR><TR><TD><SCRIPT language=javascript> var PrintThis = '/PrintArticle.aspx?ID=' + ArticleID var printURL = "('"+PrintThis+"','','dependent=yes,resizable=no,scrollbars=yes,height=700,width=635,innerHeight=630,innerWidth=600')"; document.write(' Print'); </SCRIPT><SCRIPT language=javascript> var EmailThis = '/EmailtoFriend.aspx?ID=' + ArticleID var emailURL = "('"+EmailThis+"','','dependent=yes,resizable=no,scrollbars=no,height=400,width=520')"; document.write(' E-Mail'); </SCRIPT>javascript: var emailFriendlyWin=wi...zable=no,scrollbars=no,height=400,width=520')</TD></TR></TBODY></TABLE><TABLE><TBODY><TR><TD class=RelatedLinksTitle style="FONT-WEIGHT: bold"></TD></TR><TR><TD><SCRIPT src="http://s7.addthis.com/js/152/addthis_widget.js" type=text/javascript></SCRIPT><SCRIPT type=text/javascript> addthis_pub = 'lindazinhle'; addthis_logo = 'http://www.addthis.com/images/yourlogo.png'; addthis_logo_background = 'EFEFFF'; addthis_logo_color = '666699'; addthis_brand = 'Your Site'; addthis_options = 'stumbleupon, favorites, digg, delicious, newsvine, facebook, google, live,'; </SCRIPT>http://www.addthis.com/bookmark.php</TD></TR></TBODY></TABLE>
</TD></TR></TBODY></TABLE><!--par1--><!--par0-->
<!--blurb1-->ZAMBIAN medical experts believe the food poisoning Cecilia van Deventer got at a wedding in Dullstroom, Mpumalanga, could have contributed to her death.<!--blurb0-->
<!--par1--><!--par0-->
<!--par1-->Spokesman for the Zambian Ministry of Health, Dr Canisius Banda, said yesterday that medical experts investigating the disease believe that Van Deventer, the first victim of the deadly haemorrhagic fever, could have contracted an additional infection when she visited South Africa between September 6 and 8.<!--par0-->
<!--par1-->During that weekend Van Deventer attended a wedding in Johannesburg where many of the guests suffered what is thought to be food poisoning. Everyone but Van Deventer recovered from the poisoning.<!--par0-->
<!--par1-->Banda said: ?We think it might have contributed to her death .?<!--par0-->
<!--par1-->He explained that because Van Deventer was already ill from September 4, the additional infection, together with the virus ?could have led to the full-blown septicemia and multiple organ failure? she suffered.<!--par0-->
<!--par1-->Van Deventer died on September 14 after being flown in from Zambia to the Morningside Medi-Clinic. <!--par0-->
<!--par1-->Dr Nivesh Sewlall, who treated Van Deventer, said local experts did not concur: ?They discounted the effect of the food poisoning.? <!--par0-->
<!--par1--><!--par0-->
<!--par1-->On October 5 Hannes Els, the paramedic who treated her on the emergency flight ? also succumbed to the same symptoms, while nurse Gladys Mthembu died on October 1 after she was also infected.<!--par0-->
<!--par1-->So far Zambian surveillance teams have tracked down 50 people who were in direct contact with Van Deventer. None of them has so far shown any symptoms of the disease.<!--par0-->
<!--par1-->Banda said investigations had also determined that horses brought to Lusaka from the Democratic Republic of the Congo have been ruled out as possible disease carriers, as there was no concrete evidence to indicate this.<!--par0-->
<!--par1-->Meanwhile, Van Deventer?s employers Wilderness Safaris have appointed a medical officer to offer advice to its staff. <!--par0-->
<!--par1--><!--par0-->
<!--par1-->Morningside Medi-Clinic?s Dr Nivesh Sewlall and intensive care specialist Dr Guy Richards said the ratio of known patients who suffered the disease compared to the number of contacts was a positive sign.<!--par0-->
<!--par1-->So far there have been three fatalities and the 121 people who came in contact with them have not shown any sign of being ill. <!--par0-->
<!--par1-->Richards said this compared very well with the 1996 incident, when 46-year-old theatre nurse Marilyn Lahana was infected by a Gabon doctor with the deadly Ebola virus. Lahana and the doctor died and none of the 350 they had been in direct contact with had shown signs of the disease.<!--par0-->
<!--par1-->Comparing other known types of haemorrhagic fevers, Ebola to Crimean-Congo, Richards said Ebola has a death rate of about between 60 to 80 percent, whereas Congo fever, which is endemic to parts of the Free State and the Northern Cape, was about 30 percent.<!--par0-->
<!--par1-->Richards said it was not clear what the death rate of current haemorrhagic fever was, and that is was likely that the survival rate to those infected would largely depend on their own genetic make-up and how well they responded to treatment. <!--par0-->
<!--par1-->Dr Neil Cameron from the Department of Interdisciplinary Health Sciences at the Univerisity of Stellenbosch said the probability of contracting a virus such as haemorrhagic fever depending on whether a person comes into contact with animals.<!--par0-->
<!--par1-->"Animals specifically that carry ticks that are carrying the virus. People most susceptible include farmers, hunters and people who are camping or if you are in a risk area. One would also have to come into contact with the blood of an animal. If an animal is slaughtered and a person comes into contact with this blood, they could be infected.":tiphat:http://www.thetimes.co.za/News/Article.aspx?id=859117<!--par0-->
</TD></TR></TBODY></TABLE>
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

It?s not ebola!
By Times Reporter
THE woman from Zambia who died in South Africa from a mysterious disease was in fact afflicted by cerebral edema and multi-organ failure, putting to rest suspicions that she was hit by the deadly ebola, experts have confirmed.
Five experts who carried out the investigations on two of the four deceased people revealed that the woman could have died from suspected viral infection from a tick bite that she incurred in Lusaka.
Experts from Specialty Emergency Services (SES) Corpmed Medical Centre (CMC) and Wilderness Safari said that the first victim of the disease, that had so far claimed four lives, owned horses and attended polo matches in Lusaka.
The woman is known to have walked barefoot most of the time and travelled within Africa frequently without seeking medical attention.
Between September 6-8 this year, she attended a wedding in South Africa where she might have had food poisoning along with six others all of whom had developed diarrheoa, vomiting and headache.
On September 10, she developed rash, fever and chest congestion and was attended to by a doctor at Care for Business Clinic, who told her that she had flu and sent her home.
The victim was flown to South Africa on September 12 after her condition deteriorated as she had seizures and died on September 14.
Most of the people she came in contact with, including her family, two doctors and employees at CMC had not shown any symptoms of the disease.
But a paramedic who had spent time with her during her seizure also died from multi-organ failure on October 1, almost two weeks after the meeting. He died at Morningside Hospital after being flown there.
The third victim was a nurse based at the clinic who had attended to the first patient.
The fourth one, a cleaner at the same health institution, died in the Charlotte Maxeke Johannesburg Academic Hospital.
Health Permanent Secretary, Simon Miti said in an interview yesterday that the health authorities in the country had been put on high alert against any symptoms similar to those that afflicted the four dead people.
Dr Miti said no such cases had been reported from the health institutions anywhere in the country and health officers were watching the situation.
He said apart from putting health institutions on high alert, authorities had also deployed officers at ports of entry to monitor the situation for symptoms of the disease.
He said that all the tests conducted in South Africa on the deceased people were negative to the initial suspicions and that the disease remained a mystery.
?We still have no trace of the disease in Zambia and, therefore, the nation should be calm,?;) he said.
Yesterday, the South African media reported that a 51-year-old woman was on Monday admitted to the Chris Hani Baragwanath Hospital in Johannesburg with symptoms of the unknown disease.
The Independent Online (IOL) reported that the hospital authorities could, however, not say whether the woman was related to the four earlier victims.:tiphat:
http://www.times.co.zm/news/viewnews.cgi?category=2&id=1223451811
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Published Date 08-OCT-2008
Subject PRO/AH/EDR> Undiagnosed fatalities - South Africa ex Zambia (04)

UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA (04)
****************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>
Date: Tue 7 Oct 2008
Source: The Star, South African Press Association (SAPA) report [edited]
<http://www.thestar.co.za/?fSectionId=493&fArticleId=nw20081007174346216C145841>

About 121 people who came into contact with 3 people who died of an
unknown kind of viral haemorrhagic fever remain under observation
although all appear fine, Joburg [Johannesburg] doctors said on
Tuesday [7 Oct 2008].
Doctor Lucille Blumberg of the National Institute of Communicable
Diseases said while the illness was currently "controlled," doctors
would have to wait for 21 days before they could possibly declare it
contained. Twenty-one days is the period doctors believe the illness
could still move from exposure to incubation to manifestation.
A list of 121 people who came into contact with the deceased has been
compiled and those people were having their temperatures taken every
6 hours for the 3-week period. "If we are not sure of their symptoms
we will put them in isolation to evaluate
," said treating doctor
Nivesh Sewlall.
On 12 Sep 2008, a 36-year-old woman was airlifted from Zambia to the
Morningside Medi Clinic in Sandton. She was treated for tick bite
fever and other potential infections, but died 2 days later. A
Zambian paramedic who accompanied her into the country died last
week, and a nurse at the clinic died on Sunday [5 Oct 2008]. On
Tuesday, Sewlall said of those being observed, 6 people had been
taken to hospital but 4 had already been discharged. A 51-year-old
cleaning supervisor who was admitted to Chris Hani Baragwanath
hospital with symptoms of the illness was also ready to be discharged
on Tuesday. Blumberg said her blood tests had come back clear and she was fine.
The 11-year-old son of a nurse that passed away, and his 23-year-old
nanny, were still being kept in hospital although neither displayed
any symptoms. "He is fine, but it is a traumatic time and it's more
for trauma counselling," said Sewlall. His nanny had initially
displayed a marginally high fever, but was now fine, with her blood
test normal.

Doctors said while the recent death of a cleaning staff member at the
Morningside Medic-Clinic was probably not related to the other deaths
at the hospital, they could not disregard anything at this stage.
"Scientifically we can not exclude anything until we get to 21 days,"
said Sewlall.

Sewlall and other medical officials held a news conference at the
Morningside Medi-Clinic on Tuesday [7 Oct 2008], because they said
they wanted to dispel misconceptions and panic around the illness.
Intensive care specialist professor Guy Richards said: "The public at
large are not at risk, only those with direct exposure to the 3
cases." Morningside Medi-Clinic Gauteng marketing manager Melinda
Pelser said: "This hospital is at no risk, this is where there is a
huge misunderstanding. You cannot contract the illness through air,
[you cannot contract it] unless you have had direct contact with a
patient mostly though blood, stool, and urine. We don't want panic out there."
Blumberg said there was also no outbreak of the illness in Zambia
itself and there was no risk of contracting the disease through
travel to Zambia. Sewlall said the idea that it was a disease that
doctors had never heard of and knew nothing about was incorrect.
Blumberg said: "We don't have a diagnosis as yet. It is a viral
haemorrhagic fever but we don't know what caused it." Not knowing the
cause made no difference to how patients were managed, said Richards.
"Treatment is not harmed by the fact it has not been identified."
Blumberg said various tests were being done but these could take some
time. Her institute was also collaborating with the US Centres for
Disease Control (CDC).
On Tuesday [7 Oct 2008] the World Health Organisation (WHO) said it
had flown in a laboratory expert and a disease surveillance expert to
help the South African health authorities determine the illness.
Blumberg said the 1st victim, a tourism operator, probably contracted
the illness in Lusaka [Zambia]. She lived on the outskirts of the
city in a place where there were horses and exposure to ticks.
Sewlall said she was ill for about 10 days before coming to [South
Africa] and did have a tick bite but had not identified a specific
incident of when she got ill. Sewlall said all precautions had been
in place such as masks and gowns for the nurse who contracted the illness.
--
Communicated by:
ProMED-mail Rapporteur Mary Marshall
[This report reinforces the interpretation that this is an isolated
incident stemming from a single case of an as yet unidentified 'tick
fever virus' infection contracted in Zambia and spread by nosocomial
infection in South Africa. No further cases have been recorded in
Zambia and the nosocomial spread in South Africa has been contained.
Precise identification of the tick fever virus is pending.
The HealthMap/ProMED-mail interactive map of Zambia, showing the
location of Lusaka, can be accessed at
<http://healthmap.org/promed?v=-14,27.8,5>. - Mod.CP]:tiphat:
http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,74295
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA (05) [ProMedMail.org]

UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA (05)
****************************************************
A ProMED-mail post <http: org="">
ProMED-mail is a program of the International Society for Infectious Diseases <http: org="">
Date: Wed 8 Oct 2008
Source: allAfrica.com, The Times of Zambia (Ndola) [edited] <http: com="" stories="" html="">

Zambia: It's not Ebola!
-----------------------
The woman from Zambia who died in South Africa from a mysterious disease was in fact afflicted by cerebral edema and multi-organ failure, putting to rest suspicions that she was hit by the deadly Ebola [haemorrhagic fever virus], experts have confirmed.

5 experts who carried out the investigations on 2 of the 4 deceased people revealed that the woman could have died from suspected viral infection from a tick bite that she incurred in Lusaka.

Experts from Specialty Emergency Services (SES) Corpmed Medical Centre (CMC) and Wilderness Safari said that the 1st victim of the disease, that had so far claimed 4 lives, owned horses and attended polo matches in Lusaka.

The woman is known to have walked barefoot most of the time and travelled within Africa frequently without seeking medical attention.

Between 6-8 Sep 2008, she attended a wedding in South Africa where she might have had food poisoning along with 6 others all of whom had developed diarrheoa, vomiting and headache.

On 10 Sep 2008 she developed rash, fever and chest congestion and was attended to by a doctor at Care for Business Clinic, who told her that she had flu and sent her home.

The victim was flown to South Africa on 12 Sep 2008 after her condition deteriorated as she had seizures. She died on 14 Sep 2008.

Most of the people she came in contact with, including her family, 2 doctors and employees at CMC had not shown any symptoms of the disease. But a paramedic who had spent time with her during her seizure also died from multi-organ failure on 1 Oct 2008, almost 2 weeks after the meeting. He died at Morningside Hospital after being flown there. The 3rd victim was a nurse based at the clinic who had attended to the 1st patient. The 4th one, a cleaner at the same health institution, died in the Charlotte Maxeke Johannesburg Academic Hospital.

Health Permanent Secretary, Simon Miti said in an interview yesterday [7 Oct 2008] that the health authorities in the country [Zambia] had been put on high alert against any symptoms similar to those that afflicted the 4 dead people.

Dr Miti said no such cases had been reported from the health institutions anywhere in the country and health officers were watching the situation. He said that apart from putting health institutions on high alert, authorities had also deployed officers at ports of entry to monitor the situation for symptoms of the disease. He said that all the tests conducted in South Africa on the deceased people were negative to the initial suspicions and that the disease remained a mystery.

"We still have no trace of the disease in Zambia and, therefore, the nation should be calm," he said.

Yesterday, the South African media reported that a 51-year-old woman was on Monday [6 Oct 2008] admitted to the Chris Hani Baragwanath Hospital in Johannesburg with symptoms of the unknown disease.

The Independent Online (IOL) reported that the hospital authorities could, however, not say whether the woman was related to the 4 earlier victims.
--
Communicated by: ProMED-mail


[This Zambian account of the events preceding the 4 fatalities does not emphasize the occurrence of significant haemorrhage, and no cases of haemorrhagic fever have been recorded in Zambia prior to or subsequent to the illness of the index case.

The index case fell ill 2-4 days after returning from a visit to South Africa and could have contracted her illness there rather than in Zambia.

The final results of laboratory testing in South Africa are still pending. The HealthMap/ProMED-mail interactive map of Zambia, showing the location of Lusaka, can be accessed at <http: org="" v="-14,27.8,5">. - Mod.CP]

[see also:
Undiagnosed fatalities - South Africa ex Zambia (04) 20081008.3188
Undiagnosed fatalities - South Africa ex Zambia (03) 20081007.3178
Undiagnosed fatalities - South Africa ex Zambia (02) 20081006.3157
Undiagnosed fatalities - South Africa ex Zambia: RFI 20081005.3139
Anthrax, wildlife - Zambia (Eastern) 20081002.3115

2007
----
Undiagnosed deaths - Zambia (03): apology 20071130.3866
Undiagnosed deaths - Zambia (02): pneumonic plague susp. 20071130.3862
Undiagnosed deaths - Zambia: RFI 20071129.3853
Anthrax, human, bovine - Zambia (WP) 20071115.3714

2001
----
Plague, bubonic - Zambia (04) 20010418.0769
Plague, bubonic - Zambia (03) 20010328.0631
Plague, bubonic - Zambia (02) 20010327.0621
Plague, bubonic - Zambia 20010315.0525

1998
----
Mortality, human, undiagnosed - Zambia: RFI 19980406.0636

1997
----
Plague, bubonic - Zambia (04) 19970211.0325
Plague, bubonic - Zambia (03) 19970205.0271
Plague, bubonic? - Zambia (02) 19970203.0247
Plague, bubonic - Zambia 19970131.0201

1995
----
Re: Ebola - Zambia? 19950626.0458
Ebola - Zambia? 19950623.0448]
...................................cp/ejp/dk
--
</http:></promed@promedmail.org></http:></http:></http:>​
<cite cite="http://apex.oracle.com/pls/otn/f?p=2400:1001:6655396183803646::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,74299">http://apex.oracle.com/pls/otn/f?p=..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,74299</cite>
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Swift action taken against mystery disease

9 October 2008, 10:18By Louise Flanagan

How do you deal with a possible outbreak of highly contagious or infectious disease? By acting as fast as possible, according to Gauteng Department of Health guidelines.

The first case should be regarded as an alert for a possible outbreak, and suspected outbreaks must be reported within 48 hours, then tracked and documented.

Now an assessment of the handling of Johannesburg's viral haemorrhagic fever cases is expected, for lessons to be learnt, the department said.

"We will have a debriefing," said Dr Chika Asomugha, the department's medical adviser for public health.

He said this would take place later. "The dust has not yet settled," he said. "We want to know where we went wrong."

Asomugha said the health department was "not so happy" that Morningside Medi-Clinic Private Hospital in Sandton had not alerted it to the first case, that of Cecilia van Deventer, who died of an unidentified viral haemorrhagic fever at the hospital on September 14.

The department was alerted, when a paramedic who helped to transport Van Deventer from Zambia to Morningside arrived with similar symptoms, and an alert doctor linked the cases.

The paramedic, Hannes Els, died two days later on October 2.

Since then two more people have died.

Nursing sister Gladys Mthembu, of Westonaria, who helped to care for Van Deventer, died on October 4, and contract cleaner Maria Mokubung, of Slovoville, who cleaned that area of the hospital, died on Monday morning.

The pair's families were finally contacted by health officials on Monday, after they had died.

Morningside officials said Mokubung had been ill for several months with an unrelated condition which they believe killed her, but her death is being treated as suspicious until test results confirm the cause.

Morningside Medi-Clinic manager Jaco Erasmus claimed his hospital's response had been correct.

The medi-clinic's Dr Nivesh Sewlall said the cases were reported to the department and the National Institute for Communicable Diseases immediately a link - and thus the infectious nature of the illness - was established between the two cases.

Sewlall said that before that, while doctors had considered the possibility Van Deventer had a viral haemorrhagic fever, they had decided she had tick-bite fever.

"Even if it's suspected, it should be notified,"
said Asomugha.

The department's draft National Guidelines on Epidemic Preparedness and Response 2006 says that "epidemic prone diseases", which include the viral haemorrhagic fevers, result in a high incidence of sickness and a high death rate. These appear to be the most recent guidelines.

"In order to contain and then minimise their impact, alertness and epidemic preparedness is critical," then health minister Manto Tshabalala-Msimang stated in the guidelines.

She said the emergence of unknown diseases and of known diseases with epidemic potential called for a rapid response.

"Outbreaks, just as other emergencies, can reach disastrous proportions when there is poor preparation and a continual weak, unco-ordinated response."

The guidelines list viral haemorrhagic fevers as a priority, with a single case being an alert.

Patients with these illnesses should be isolated.

The guidelines require national, provincial and district departments of health to have outbreak response teams.

Response to a confirmed outbreak includes: alerting medical supervisors of health facilities, identifying areas or people at risk, making sure of emergency supplies and resources, and assigning clear responsibilities to individuals or units for specific responses.

Efforts must be made to find all people with signs of the disease, and officials must search for other cases.

Officials should "keep the public informed to calm fear and to encourage co-operation with the outbreak response".

Officials should inform families and contacts of confirmed or suspected cases about the disease.:tiphat:http://www.thestar.co.za/index.php?fSectionId=&fArticleId=vn20081009060258175C851362
 
Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Re: UNDIAGNOSED FATALITIES - SOUTH AFRICA ex ZAMBIA: REQUEST FOR INFORMATION [ProMedMail.org]

Killer-fever: No need to panic

9 October 2008, 10:41
There is not cause for "panic" about the outbreak of suspected haemorrhagic fever in Gauteng which has claimed three lives, government spokesperson Themba Maseko said on Thursday.

Briefing the media after Cabinet's regular meeting on Wednesday, Maseko said the executive was satisfied that health authorities and professionals had responded quickly, appropriately and with the highest levels of professionalism to contain the suspected virus.

"Government's message to the public is 'do not panic, we are dealing with the situation'," Maseko said.:tiphat:http://www.thestar.co.za/?fSectionId=&fArticleId=nw20081009103910291C343338
 
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Response team to help tackle killer virus
<TABLE cellSpacing=0 cellPadding=4 width=10 align=left border=0 valign="top"><TBODY><TR><TD align=left>
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Government says cabinet is satisfied with the response of health authorities to contain the virus
</TD></TR></TBODY></TABLE>October 09, 2008, 12:45

Cabinet says a Rapid Response Team has been established to co-ordinate efforts to deal with the outbreak of the hemorrhagic fever in Gauteng. During a media briefing after yesterday's Cabinet meeting, members of the public were urged not to panic over the outbreak.

Government spokesperson Themba Maseko says cabinet is satisfied with the response of health authorities to contain the virus. The response team will co-ordinate efforts to deal with the situation and constantly monitor developments at all hospitals and clinics.

Government says it is working flat out to control the situation. It says it is also enlisted the expertise of global organisations like the World Health Organisation and the United States Centre for Disease Control. Even health-care workers are being trained on how to deal with patients who present symptoms of this fever.

Maseko says the national outbreak response team is actively working around the clock to support the provincial outbreak response teams with guidelines, active surveillance and the tracing of contacts.:tiphat:http://www.sabcnews.com/south_africa/health/0,2172,178009,00.html
 
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<TABLE width="100%"><TBODY><TR vAlign=top><TD>No need to panic over Gauteng virus, says Cabinet

CAPE TOWN, SOUTH AFRICA Oct 09 2008 13:05
</TD></TR></TBODY></TABLE>


There is no cause for panic over an outbreak of suspected haemorrhagic fever in Gauteng that has claimed three lives, government spokesperson Themba Maseko said on Thursday.

Briefing the media after the Cabinet's regular meeting on Wednesday, Maseko said the executive was satisfied that health authorities and professionals had responded quickly, appropriately and with the highest levels of professionalism to contain the suspected virus.

"The meeting was satisfied that the Department of Health, together with health professionals and experts from both the public and private sectors, was doing all that is necessary to prevent the spread of the virus and ensure that there is no further loss of life," he said.

The national outbreak response team is working around the clock to support provincial response teams with guidelines, active field surveillance and tracing contacts, he said.

A rapid response team has been established, consisting of public and private health sector representatives, to coordinate efforts to deal with the situation promptly. This team meets every day to coordinate responses and constantly monitors the situation in all hospitals and clinics.

The government is also working with the World Health Organisation and the United States Centres for Disease Control (CDC) to access their global expertise in dealing with outbreak responses.

The CDC has undertaken to expedite the processing of samples to ensure test results are made available as quickly as possible, he said.

An emergency hotline (Tel: 011 564 2083) has been established to deal with enquiries.

Healthcare workers are being trained to deal with patients showing symptoms of viral haemorrhagic fevers, and port health services are being strengthened to deal with any situation, as are members of the border control operational coordinating committee.
"Government's message to the public is: do not panic, we are dealing with the situation. We will continue to monitor the situation very closely and we are confident that the test results will shed more light on this virus so that appropriate measures could be put in place as soon as possible," Maseko said.:tiphat:http://www.mg.co.za/article/2008-10-09-no-need-to-panic-over-gauteng-virus-says-cabinet
 
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Warning on infected dead bodies

October 09 2008 at 10:38AM
Be very, very careful with the bodies.

That's the rule when people have died from a highly infectious disease such as a viral haemorrhagic fever.

Dr Chika Asomugha said autopsies could not be carried out on the bodies, due to the risk of infection to those doing the procedure, and there were rules for disposing of the bodies.

Asomugha, medical adviser for public health for the Gauteng department of health, said people working with the bodies had to use precautions like protective clothing to avoid infection.

The bodies must be put in sealable bags, then into special lead-lined coffins, "and it should not be opened by anybody," he saidWhen the bodies are transported, they must be escorted by police to ensure the coffins are not opened.

Bodies should be buried rather than cremated.

The body of the first person who died from the viral haemorrhagic fever, Cecilia van Deventer, was not treated this way as doctors believed at the time she had ordinary tick-bite fever. She was cremated.

Those who dealt with her body have been put on the list of people to be monitored.

The bodies of the other three suspected cases are yet to be buried.

One is with a private specialised undertaker and the other two are in government mortuaries. http://www.iol.co.za/index.php?set_id=1&click_id=13&art_id=vn20081009060307911C618416
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Hospital staff to check themselves every six hours

DR NIVESH Sewlall and 54 other medical staff at the Morningside Medi-Clinic have found themselves on the other side of the thermometer.




Virus: Food-poisoning claim



Killer virus: cleaning supervisor healthy


They are being monitored to see if they have contracted the deadly haemorrhagic fever virus.

For at least 14 days, every six hours the doctors have to take their temperature and phone in the results , while they continue with their daily hospital routines.


The Sandton hospital was at the centre of the haemorrhagic fever scare. The three people who died from the viral disease, Zambian Cecilia van Deventer, paramedic Hannes Els and nursing sister Gladys Mthembu, were all linked to the facility.

?There is a fair amount of anxiety among the staff, but we are trying to keep things as normal as possible ,? Sewlall said.

He was the doctor who treated Van Deventer and Els, and feels that Mthembu?s death has affected the tight-knit group of intensive-care nurses and doctors more than fears about contracting the virus.

?Part of my job is to allay their fears . E very interaction with a sick patient brings with it the potential to unwittingly contract a life-threatening disease ,? Sewlall said.

The nursing staff have received trauma debriefing.

Mthembu?s 11 year-old son and his 28-year-old nanny are still in isolation at the hospital, for emotional recovery. Their physical health appears not to have been compromised .

It is believed they will be released today.


Mthembu?s death is hard on her elderly father, from Westonaria, west of Johannesburg, who says he fears he will be ostracised by his community because of their fears of the disease.

Sewlall said: ?E xperts are not sure what type of haemorrhagic fever it is. W e have mixed feelings about it.


?But it is distinctly attached to the human tragedy that has happened,? he said.


The 66 medical staff and individuals who were in direct contact with Mthembu after she was admitted to the Sir Albert Robinson hospital on the West Rand are also still being monitored.

Test results for blood samples obtained from Els and Mthembu, which were sent to the US Centres for Disease Control to determine the origin and type of virus, are expected in the coming days.



The cabinet said yesterday that ?there is no cause for panic over the outbreak of suspected haemorrhagic fever in Gauteng which has claimed three lives.?

Government spokesman Themba Maseko said the executive was satisfied that health authorities and professionals had responded quickly, appropriately and with the highest levels of professionalism to contain the suspected virus.

http://www.thetimes.co.za/News/Article.aspx?id=860123
 
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Daughter cannot bid mom farewell

October 10 2008 at 08:34AM
Lebohang Mokubung is worried that she can't say goodbye to her mother properly.

Her mother, Maria Mokubung, 38, died at Charlotte Maxeke Johannesburg Academic Hospital on Monday.

She was a contract cleaner at Morningside Medi-Clinic, where two patients died recently from a still-unidentified viral haemorrhagic fever.

'I wanted my mother to have a normal funeral'
Her death is being treated as related to this until tests prove otherwise.

Unlike any other grieving family, Lebohang wasn't able to touch her mother's body to say farewell, and could see her face only through the thick plastic of a body bag.She is to be buried on Sunday.

Mokubung cleaned the area of the hospital where Cecilia van Deventer - the first patient to die from the fever - was being treated.

"I am worried that my mother will not be buried like other people," Lebohang said.

"We will not be able to dress her. This is so difficult for me. I wanted my mother to have a normal funeral."

Professor Adrian Duse of Charlotte Maxeke hospital and undertaker Molefi Kupane confirmed the strict regulations around funerals for those who die from highly infectious diseases.

Duse, head of clinical microbiology and infectious diseases at the hospital, said the body could be viewed, but only under controlled conditions to prevent infection.

The body is wiped down with a disinfectant solution containing bleach, then placed in an impervious body bag which has a transparent section over the face, allowing for identification and viewing.

This bag is sealed and wiped down with disinfectant and placed inside another, non-transparent bag, Duse said.

An undertaker may open the outer bag partially to allow viewing of the face through the transparent window of the closed inner bag, he said.

"They won't be able to see so well and they won't be able to touch her. It's going to be a steep hill for them," said Kupane, the manager of Kupane Funerals in Orlando, Soweto, which is conducting the funeral.

"They can't dress her up, they can't do the ritual washing - the impact of that is that closure is so much more remote.

"When you wash your deceased, when you dress them up, you give them that last bit of dignity. They will be deprived of that unfortunately."

The undertakers used three body bags, adding an extra one for safety. Kupane said a zinc-lined coffin was used to protect underground water. Lead-lined coffins were no longer used.

Kupane said the state was not paying for the funeral, but that Kupane was not charging the family more than for an ordinary funeral. "You take a matter case by case sometimes."

Mokubung worked for Prestige cleaners and cleaned the area of the hospital where Van Deventer lay before she died on September 14.

Paramedic Hannes Els, who helped transport Van Deventer from Zambia to South Africa, returned to Morningside Medi-clinic with similar symptoms on September 27. He died on October 2. A nurse, Gladys Mthembu, died on Saturday.

Lebohang said her mother fell ill on September 26. She died on Monday.

Morningside Medi-Clinic officials said Mokubung had been ill for several months with an unrelated condition which they believe killed her, but her death has to be treated as suspicious as she had had contact with Van Deventer.

Lebohang said her mother was not sickly, but had to go for check-ups because she was HIV-positive.

"I know my mother was HIV-positive. I want to know if she died from that or if she died from the infectious disease. She was not always sick. She was still able to go to work," she said.

Her mother returned from work on September 26, a Friday, seriously ill.

She was unable to go to work on the Monday.
http://www.iol.co.za/index.php?set_id=1&click_id=&art_id=vn20081010060328911C169384
 
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SA race to contain deadly virus continues

Government says there is no cause for alarm following the outbreak of suspected haemorrhagic fever

October 10, 2008, 06:15

South African health professionals are working tirelessly to narrow down the source of the fatal virus that has claimed four lives. They suspect it could be a strain of a deadly infectious disease - Viral Haemorragic Fever.

There is still no breakthrough on the source of the deadly virus and health professionals remain baffled. Zambian authorities have dispelled reports that the source emanated from that country. Zambian High Commissioner Leslie Mbula says they are continuing with checks on animals, plants and individuals coming into Zambia so that they don?t have a repeat of transit occurrences of the disease. He has assured the public that Zambia is very safe.

Meanwhile calls have again been made for the public not to panic. Government spokesperson Themba Maseko says the centre for Disease Control has undertaken to expedite the processing of samples to ensure that tests are made available as quickly as possible.

Three weeks ago the virus claimed its first victim, a Zambian travel agent flown into the country for treatment. The second victim was a Zambian paramedic who accompanied her. Earlier in the week, a 34-year-old nurse and a cleaner from the Morningside Clinic also died.


http://www.sabcnews.com/south_africa/health/0,2172,178036,00.html
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WHO | Unknown disease in South Africa and Zambia

Unknown disease in South Africa and Zambia

10 October 2008 --

On 12 September, an office employee at a safari tour company living and working in Zambia underwent medical evacuation to South Africa with an as-yet unknown disease. The patient died in a Johannesburg hospital on 14 September.


On 27 September, the paramedic who cared for the index case during her evacuation to South Africa was admitted to hospital in Johannesburg where he died on 2 October.

In addition, a nurse who cared for the index case in South Africa died on 5 October in Johannesburg.

Laboratory analysis has been conducted in South Africa at the Special Pathogens Unit, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service.

Samples have, so far, tested negative for a series of viral haemorrhagic fevers and other common infectious disease pathogens.

Tests to identify the pathogen continue at the NICD in South Africa and further testing will be performed at the Special Pathogens and Infectious Disease Pathology branches of the Centers for Disease Control and Prevention (CDC), Atlanta, United States.

CDC and NICD are technical partners in the Global Outbreak Alert and Response Network (GOARN ).

Clinical features common to the three patients initially include fever, headache, diarrhoea and myalgia developing into rash and hepatic dysfunction, followed by rapid deterioration and death.

Bleeding was not a marked clinical feature (NICD report (.pdf)).

There are no further known symptomatic cases, either in Zambia or in South Africa.

121 known contacts of the fatal cases are being traced in South Africa and 23 in Zambia.

WHO and its partners are actively supporting the investigation at provincial and national levels.

Epidemiologists from the WHO African Regional Office have arrived to assist both countries, and personal protective equipment (PPE) and sampling equipment are en route to Lusaka.

WHO is also providing support to the Ministries of Health of the two countries with epidemiological investigations, active case finding and follow-up of contacts.

While the investigations and follow-up of contacts continue, there have been no new cases since the last death on 4 October.

There is no indication at this point of the need for any restriction of travel to or from Zambia or South Africa and no special measures are required for passengers arriving from these countries.


WHO African Regional Office is providing updated information to the WHO Country Offices in the neighbouring countries.
--
<cite cite="http://www.who.int/csr/don/2008_10_10/en/index.html">WHO | Unknown disease in South Africa and Zambia</cite>
 
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Source: http://www.news24.com/News24/South_Africa/News/0,,2-7-1442_2407968,00.html

Virus: WHO tracing 144 people
10/10/2008 20:02 - (SA)

Geneva - Up to 144 people who had been in contact with three people killed by a mysterious illness in southern Africa are being traced, the World Health Organisation said on Friday.

A statement said that "121 known contacts of the fatal cases are being traced in South Africa and 23 in Zambia."

The organisation's spokesperson Fadela Chaib also told journalists in Geneva that 121 of those are already under observation, and that "all are doing well".


WHO epidemiologists have been hunting for the cause of the mysterious illness which killed 36-year-old Cecilia van Deventer as well as a paramedic and a nurse, she added.

The disease is believed to be a haemorrhagic fever, but "three haemorrhagic fevers have been ruled out - Ebola, Rift Valley and Lhasa. They are not the cause of the disease," said Chaib.

Van Deventer arrived in South Africa on September 12 and died two days later after being treated for what was believed to be tick-bite fever.

The medic who accompanied her, Hannes Els, 36, also from Zambia died two days later with flu-like symptoms.

Gladys Mthembu, a 34-year-old Morningside Medi-Clinic nurse who died a few days later.

- AFP
 
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Outbreak of an acute disease, ex-Zambia.

[Source: http://www.nicd.ac.za/pubs/communique/2008/NICDSpecialCommOct_alert01.pdf (from above mentioned WHO update at post #76) - IOH]

An outbreak of an (as yet) unknown disease has been identified in South Africa.

To date there have been four linked cases, all of whom have died.

The index case was a Zambian national, resident in Lusaka who had close contact with horses and a history of possible tick exposure.

The subsequent two patients had close contact with the index case in
a healthcare setting: a paramedic involved in her medical evacuation to South Africa and an intensive care nurse in Johannesburg.

These two patients became ill approximately 7 days after exposure to the index case.

The fourth case has been confirmed to have an alternative diagnosis.

Clinical and laboratory features common to the three probable patients include a prodromal illness of approximately 7 days with fever, headache, diarrhoea and myalgia, followed by an acute illness
with fever ≥38oC, a morbilliform rash in two patients, and thrombocytopenia and mild hepatic dysfunction in two patients.

An initial improvement was reported in the two latter patients, and all three had a sudden and marked deterioration in mental state, rhabdomyolysis in one case, and evidence of acute and severe hepatic necrosis.

Bleeding was not a marked clinical feature although oozing from
venepuncture sites was noted as well as a petechial rash in one patient.

Laboratory testing for the viral haemorrhagic fevers (VHFs) has been conducted by the Special Pathogens Unit at the National Institute for
Communicable Diseases (NICD), a branch of the National Health Laboratory Service.

Multiple nucleicacid and antigen detection assays as well as serological tests have to date been negative for Crimean-Congo haemorrhagic fever (CCHF), Ebola, Marburg, Lassa fever and Rift Valley fever viruses.

Serology is negative for the Hantaviruses.

The final results for viral culture in animal and cell cultures are pending.

Only specimens from cases 2, 3 and 4 were available for testing. The index case had been given a diagnosis of ?tick bite fever? and no specimens were available for testing (she died shortly after arrival in SA).

Negative results to date may be explained by several factors.

These could include the timing of collection (taken late ? day 10 of illness), and virus variants not detected by current molecular and serological assays. Blood cultures to date have been negative. Further laboratory testing is underway.

No further secondary cases have been identified and there is no indication of similar cases occurring in Zambia. It seems likely that this is an isolated
case with secondary transmission in the nosocomial setting. Given the high mortality, nosocomial transmission and clinical presentation, a viral haemorrrhagic fever remains possible.

All contacts of cases, including healthcare workers and laboratory staff are under surveillance and are all currently well. There is no need to isolate such contacts unless they become ill. Returning travellers from Zambia should be managed as previously; a good history, clinical assessment and laboratory investigations as indicated. Only individuals who have been in direct contact with the three probable cases are considered to be at risk at present and should be under surveillance.

The recent case of Crimean-Congo haemorrhagic fever (CCHF) from Calvinia in the Northern Cape Province is not linked to the above cluster.

CCHF is endemic in the province. The patient is a 44-year-old abattoir worker and is clinically stable. October 2008.
-
[Document created October 8, 2008.]
-----
 
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Marburg, Ebola ruled out

10 October 2008, 14:21

By Kanina Foss

Investigations conducted by Zambian laboratories on samples from the first two victims of the mystery virus have ruled out Ebola and Marburg.

The results of further tests are expected within a week. In addition, samples from the same two patients have been sent to the Centres for Disease Control (CDC) in the US and the Centre for Zoonotic Diseases in Japan.

The Zambian Health Ministry emphasises that the country hasn't seen more cases of the virus, which has killed at least three people.

Three private hospitals in Lusaka attended to tourism manager Cecilia van Deventer and paramedic Hannes Els, both SA nationals living in Lusaka, before they were airlifted to Johannesburg.

The hospitals have been visited by a task team comprising the Health Ministry, the World Health Organisation, the CDC, and government officials, medical specialists and academics.

The team has found that none of the people who came into contact with the two patients have shown symptoms.

A research centre for the ministry of agriculture and co-operatives is being prepared as a possible isolation site if more cases occur.

The situation was under control, said Health Minister Dr Brian Chituwo

http://www.capetimes.co.za/?fSectionId=3531&fArticleId=vn20081010060218947C140211
 
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