tetano
Editor, Senior Moderator
Phytochemistry. 2012 Oct 22. pii: S0031-9422(12)00419-0. doi: 10.1016/j.phytochem.2012.09.008. [Epub ahead of print]
Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.
Dong JY, Ma XY, Cai XQ, Yan PC, Yue L, Lin C, Shao WW.
Source
School of Pharmacy, Wenzhou medical college, Wenzhou 325035, PR China. Electronic address: jianyd163@163.com.
Abstract
Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC(50) values ranged from 1.81 to 9.23μM, and SI values ranged from 9.83 to 36.26.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
23098899
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23098899
Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.
Dong JY, Ma XY, Cai XQ, Yan PC, Yue L, Lin C, Shao WW.
Source
School of Pharmacy, Wenzhou medical college, Wenzhou 325035, PR China. Electronic address: jianyd163@163.com.
Abstract
Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC(50) values ranged from 1.81 to 9.23μM, and SI values ranged from 9.83 to 36.26.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
23098899
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23098899