tetano
Editor, Senior Moderator
Pediatr Int. 2011 May 23. doi: 10.1111/j.1442-200X.2011.03398.x. [Epub ahead of print]
Serum KL-6 and SP-D in children with 2009 pandemic H1N1 influenza infection.
Nishida S, Fukazawa R, Imai T, Takeda S, Hayakawa J, Takeuchi H, Shimizu K, Kawakami Y, Takase M.
Source
Nippon Medical School, Tama-Nagayama Hospital Department of Pediatrics.
Abstract
Background: A global pandemic influenza A (H1N1) outbreak occurred in 2009. Rapid progress of respiratory distress is one of the characteristic features of pandemic influenza A (H1N1) infection. However, the physiologic mechanism causing hypoxia in pandemic influenza A (H1N1) infection has not been elucidated. Methods: We evaluated the serum levels of KL-6 and surfactant protein D (SP-D) in 21 cases of pandemic influenza A (H1N1) infection associated with chest radiographic abnormality in order to estimate alveolar involvement. And we also analyzed clinical features of them. Results: All of the patients had high fever, and rapidly progressed to respiratory distress within several days of the disease onset. Despite the mild radiographic abnormality in these cases, their dyspnea was severe and they had low blood oxygen saturation levels. Many of them had a history of allergic diseases including asthma. Serum KL-6 and SP-D levels on admission were 191 ? 69 U/ml and 32.6 ? 18.9 ng/ml, respectively. These two levels remained below the upper normal limit 1 week later. There were no clear relations between specific clinical symptoms and KL-6 or SP-D levels. All cases were treated with oseltamivir and/or zanamivir, and improved without mechanical ventilation management. Conclusion: KL-6 and SP-D elevation were not significant in pandemic influenza A (H1N1) infection associated with chest radiographic abnormality. In pandemic influenza A (H1N1) infection, alveolar involvement was estimated to be little, and severe respiratory distress was probably caused by obstruction of peripheral bronchi.
? 2011 The Authors. Pediatrics International ? 2011 Japan Pediatric Society.
PMID:
21605280
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21605280
Serum KL-6 and SP-D in children with 2009 pandemic H1N1 influenza infection.
Nishida S, Fukazawa R, Imai T, Takeda S, Hayakawa J, Takeuchi H, Shimizu K, Kawakami Y, Takase M.
Source
Nippon Medical School, Tama-Nagayama Hospital Department of Pediatrics.
Abstract
Background: A global pandemic influenza A (H1N1) outbreak occurred in 2009. Rapid progress of respiratory distress is one of the characteristic features of pandemic influenza A (H1N1) infection. However, the physiologic mechanism causing hypoxia in pandemic influenza A (H1N1) infection has not been elucidated. Methods: We evaluated the serum levels of KL-6 and surfactant protein D (SP-D) in 21 cases of pandemic influenza A (H1N1) infection associated with chest radiographic abnormality in order to estimate alveolar involvement. And we also analyzed clinical features of them. Results: All of the patients had high fever, and rapidly progressed to respiratory distress within several days of the disease onset. Despite the mild radiographic abnormality in these cases, their dyspnea was severe and they had low blood oxygen saturation levels. Many of them had a history of allergic diseases including asthma. Serum KL-6 and SP-D levels on admission were 191 ? 69 U/ml and 32.6 ? 18.9 ng/ml, respectively. These two levels remained below the upper normal limit 1 week later. There were no clear relations between specific clinical symptoms and KL-6 or SP-D levels. All cases were treated with oseltamivir and/or zanamivir, and improved without mechanical ventilation management. Conclusion: KL-6 and SP-D elevation were not significant in pandemic influenza A (H1N1) infection associated with chest radiographic abnormality. In pandemic influenza A (H1N1) infection, alveolar involvement was estimated to be little, and severe respiratory distress was probably caused by obstruction of peripheral bronchi.
? 2011 The Authors. Pediatrics International ? 2011 Japan Pediatric Society.
PMID:
21605280
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21605280