tetano
Editor, Senior Moderator
J Infect Dis. 2013 Dec 10. [Epub ahead of print]
Serum antibody response to M2 surface protein following natural infection with 2009 pandemic H1N1 influenza A virus in humans.
Zhong W, Reed C, Blair PJ, Katz JM, Hancock K; for the Influenza Serology Working Group.
Source
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
Abstract
Natural infection-induced humoral immunity to M2 protein of influenza A viruses in humans is not fully understood at present. Existing evidence suggests that anti-M2 antibody responses following influenza A virus infection are weak and/or transient. We show that seroprevalence of anti-M2 antibodies increased with age in 317 sera from healthy individuals in the U.S. in 2007-08. Infection with 2009 pandemic H1N1 influenza A virus [A(H1N1)pdm09] elicited a recall serum antibody response to M2 protein of the A(H1N1)pdm09 virus in 47% of the affected 118 individuals tested. Anti-M2 antibody responses were more robust among individuals with preexisting antibodies to M2 protein. Moreover, the antibodies induced as a result of infection with A(H1N1)pdm09 virus were cross-reactive with M2 protein of seasonal influenza A viruses. These results emphasize the need to further investigate the possible roles of anti-M2 antibodies in human influenza A virus infection.
PMID:
24325965
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24325965
Serum antibody response to M2 surface protein following natural infection with 2009 pandemic H1N1 influenza A virus in humans.
Zhong W, Reed C, Blair PJ, Katz JM, Hancock K; for the Influenza Serology Working Group.
Source
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
Abstract
Natural infection-induced humoral immunity to M2 protein of influenza A viruses in humans is not fully understood at present. Existing evidence suggests that anti-M2 antibody responses following influenza A virus infection are weak and/or transient. We show that seroprevalence of anti-M2 antibodies increased with age in 317 sera from healthy individuals in the U.S. in 2007-08. Infection with 2009 pandemic H1N1 influenza A virus [A(H1N1)pdm09] elicited a recall serum antibody response to M2 protein of the A(H1N1)pdm09 virus in 47% of the affected 118 individuals tested. Anti-M2 antibody responses were more robust among individuals with preexisting antibodies to M2 protein. Moreover, the antibodies induced as a result of infection with A(H1N1)pdm09 virus were cross-reactive with M2 protein of seasonal influenza A viruses. These results emphasize the need to further investigate the possible roles of anti-M2 antibodies in human influenza A virus infection.
PMID:
24325965
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24325965