tetano
Editor, Senior Moderator
J Clin Virol. 2015 Nov 17;74:32-36. doi: 10.1016/j.jcv.2015.11.019. [Epub ahead of print]
[h=1]Serum and mucosal antibodies fail as prognostic markers during critical influenza A infection.[/h] Grund S[SUP]1[/SUP], Michel S[SUP]2[/SUP], Barthuber C[SUP]3[/SUP], Adams O[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Previous studies have indicated that the absence of serum antibodies to influenza A H1N1 virus on day 4 after onset of symptoms predicted a fatal outcome in patients critically ill with influenza. The underlying mechanism was suggested to be the trapping of anti-influenza antibodies in pulmonary immune complexes.
[h=4]OBJECTIVES:[/h] To study serum and mucosal antibodies as prognostic markers in patients with severe influenza A H1N1 infection.
[h=4]STUDY DESIGN:[/h] Blood and respiratory samples (n=324) from 12 patients with severe influenza were analysed for anti-H1N1 antibodies with and without immune complex dissociation from symptom onset until convalescence or death (follow up 14-169 days). Eleven healthy subjects were analysed for comparison.
[h=4]RESULTS:[/h] One of the 12 patients died from influenza pneumonia and had no detectable anti-H1N1 serum antibodies. However, also 2 of the 11 surviving patients remained negative for anti-H1N1 serum antibodies during follow-up (20 and 41 days, respectively). In six of the 11 survivors serum antibodies on day 4 were negative, but turned positive between day 7 and 23. In the remaining 3 patients antibodies were detected in the first 4 days of illness. Mucosal IgG or IgA was detected in all of the patients regardless of their clinical outcome and in 4 of 11 healthy subjects. No mucosal immune complexes were found in the patient who died but were detected in 3 of the 11 survivors.
[h=4]CONCLUSIONS:[/h] This study suggests that no prognostic conclusions can be drawn from anti-H1N1 serum and mucosal antibodies in patients with severe influenza.
Copyright ? 2015 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Antibodies; Immune complexes; Influenza; Mucosal antibodies; Prognostic markers
PMID: 26655265 [PubMed - as supplied by publisher]
[h=1]Serum and mucosal antibodies fail as prognostic markers during critical influenza A infection.[/h] Grund S[SUP]1[/SUP], Michel S[SUP]2[/SUP], Barthuber C[SUP]3[/SUP], Adams O[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Previous studies have indicated that the absence of serum antibodies to influenza A H1N1 virus on day 4 after onset of symptoms predicted a fatal outcome in patients critically ill with influenza. The underlying mechanism was suggested to be the trapping of anti-influenza antibodies in pulmonary immune complexes.
[h=4]OBJECTIVES:[/h] To study serum and mucosal antibodies as prognostic markers in patients with severe influenza A H1N1 infection.
[h=4]STUDY DESIGN:[/h] Blood and respiratory samples (n=324) from 12 patients with severe influenza were analysed for anti-H1N1 antibodies with and without immune complex dissociation from symptom onset until convalescence or death (follow up 14-169 days). Eleven healthy subjects were analysed for comparison.
[h=4]RESULTS:[/h] One of the 12 patients died from influenza pneumonia and had no detectable anti-H1N1 serum antibodies. However, also 2 of the 11 surviving patients remained negative for anti-H1N1 serum antibodies during follow-up (20 and 41 days, respectively). In six of the 11 survivors serum antibodies on day 4 were negative, but turned positive between day 7 and 23. In the remaining 3 patients antibodies were detected in the first 4 days of illness. Mucosal IgG or IgA was detected in all of the patients regardless of their clinical outcome and in 4 of 11 healthy subjects. No mucosal immune complexes were found in the patient who died but were detected in 3 of the 11 survivors.
[h=4]CONCLUSIONS:[/h] This study suggests that no prognostic conclusions can be drawn from anti-H1N1 serum and mucosal antibodies in patients with severe influenza.
Copyright ? 2015 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Antibodies; Immune complexes; Influenza; Mucosal antibodies; Prognostic markers
PMID: 26655265 [PubMed - as supplied by publisher]