tetano
Editor, Senior Moderator
Arch Med Res. 2015 Mar 18. pii: S0188-4409(15)00044-2. doi: 10.1016/j.arcmed.2015.03.001. [Epub ahead of print]
[h=1]Seroprevalence of Pandemic A(H1N1) pmd09 Virus Antibodies in Mexican Health Care Workers Before and After Vaccination.[/h] Aguilar-Madrid G[SUP]1[/SUP], Castel?n-Vega JA[SUP]2[/SUP], Ju?rez-P?rez CA[SUP]3[/SUP], Ribas-Aparicio RM[SUP]2[/SUP], Estrada-Garc?a I[SUP]2[/SUP], Baltierra-Jasso L[SUP]2[/SUP], Cervantes-Serv?n N[SUP]4[/SUP], M?ndez-Ortega V[SUP]2[/SUP], Haro-Garc?a LC[SUP]5[/SUP], S?nchez-Rom?n FR[SUP]6[/SUP], Ortiz-Navarrete V[SUP]7[/SUP], Fabila-Castillo LH[SUP]2[/SUP], Maga?a-Hern?ndez A[SUP]2[/SUP], Ch?vez-Negrete A[SUP]8[/SUP], Salamanca-G?mez FA[SUP]9[/SUP], Jim?nez-Alberto A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND AND AIMS:[/h] In April 2009, a new strain of influenza A(H1N1) was identified in Mexico and in the U.S. In June 2009, WHO declared this a pandemic. Health care workers constituted a risk group for their close contact with infected individuals. The aim was to estimate seropositivity for A(H1N1)pdm09 in health staff at the Instituto Mexicano del Seguro Social.
[h=4]METHODS:[/h] A two-stage cross-sectional study, before and after vaccination in the same workers, was performed on a random sample of health-care workers. A socio-occupational questionnaire was applied and serum antibodies against influenza A(H1N1)pdm09 were determined through neutralization of retroviral pseudotypes; two logistic regression models for both were constructed.
[h=4]RESULTS:[/h] The average (median/mean) age of 1378 participants from 13 work centers was 41.7 years and 68.7% (947) were women. Seroprevalence for the first stage was 26.5% (365) (7.4-43%) vs. 20.8% (11) in a control group from the blood bank; for the second stage, the vaccinated group was 33% (215) (18.2-47%) and 27% (196) (11.6-50%) for the unvaccinated group. In regression models, seropositivity was associated with occupational exposure to suspected influenza infected patients, being physicians, and being vaccinated.
[h=4]CONCLUSIONS:[/h] Seropositivity against pandemic virus is similar to what was reported, both for vaccinated (2.8-40.9%) and unvaccinated (18.8-64.7%). Low seroprevalence in the vaccinated group indicates that between 67% and 73% were susceptible to infection. Given the relatively low vaccine-induced seropositivity, it is imperative to increase, hygiene and safety for health staff and at-risk populations, and strengthen epidemiological surveillance.
Copyright ? 2015 IMSS. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Health care workers; Influenza A(H1N1)pdm09; Retroviral pseudotypes; Seroprevalence; Vaccination
PMID: 25796508 [PubMed - as supplied by publisher]
[h=1]Seroprevalence of Pandemic A(H1N1) pmd09 Virus Antibodies in Mexican Health Care Workers Before and After Vaccination.[/h] Aguilar-Madrid G[SUP]1[/SUP], Castel?n-Vega JA[SUP]2[/SUP], Ju?rez-P?rez CA[SUP]3[/SUP], Ribas-Aparicio RM[SUP]2[/SUP], Estrada-Garc?a I[SUP]2[/SUP], Baltierra-Jasso L[SUP]2[/SUP], Cervantes-Serv?n N[SUP]4[/SUP], M?ndez-Ortega V[SUP]2[/SUP], Haro-Garc?a LC[SUP]5[/SUP], S?nchez-Rom?n FR[SUP]6[/SUP], Ortiz-Navarrete V[SUP]7[/SUP], Fabila-Castillo LH[SUP]2[/SUP], Maga?a-Hern?ndez A[SUP]2[/SUP], Ch?vez-Negrete A[SUP]8[/SUP], Salamanca-G?mez FA[SUP]9[/SUP], Jim?nez-Alberto A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND AND AIMS:[/h] In April 2009, a new strain of influenza A(H1N1) was identified in Mexico and in the U.S. In June 2009, WHO declared this a pandemic. Health care workers constituted a risk group for their close contact with infected individuals. The aim was to estimate seropositivity for A(H1N1)pdm09 in health staff at the Instituto Mexicano del Seguro Social.
[h=4]METHODS:[/h] A two-stage cross-sectional study, before and after vaccination in the same workers, was performed on a random sample of health-care workers. A socio-occupational questionnaire was applied and serum antibodies against influenza A(H1N1)pdm09 were determined through neutralization of retroviral pseudotypes; two logistic regression models for both were constructed.
[h=4]RESULTS:[/h] The average (median/mean) age of 1378 participants from 13 work centers was 41.7 years and 68.7% (947) were women. Seroprevalence for the first stage was 26.5% (365) (7.4-43%) vs. 20.8% (11) in a control group from the blood bank; for the second stage, the vaccinated group was 33% (215) (18.2-47%) and 27% (196) (11.6-50%) for the unvaccinated group. In regression models, seropositivity was associated with occupational exposure to suspected influenza infected patients, being physicians, and being vaccinated.
[h=4]CONCLUSIONS:[/h] Seropositivity against pandemic virus is similar to what was reported, both for vaccinated (2.8-40.9%) and unvaccinated (18.8-64.7%). Low seroprevalence in the vaccinated group indicates that between 67% and 73% were susceptible to infection. Given the relatively low vaccine-induced seropositivity, it is imperative to increase, hygiene and safety for health staff and at-risk populations, and strengthen epidemiological surveillance.
Copyright ? 2015 IMSS. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Health care workers; Influenza A(H1N1)pdm09; Retroviral pseudotypes; Seroprevalence; Vaccination
PMID: 25796508 [PubMed - as supplied by publisher]