tetano
Editor, Senior Moderator
Taiwan J Obstet Gynecol. 2013 Sep;52(3):356-9. doi: 10.1016/j.tjog.2013.06.002.
Seroprevalence of influenza A H1N1 and seroconversion of mothers and infants induced by a single dose of monovalent vaccine.
Chao A, Huang YC, Chang YL, Wang TH, Chang SD, Wu TS, Wu TL, Chao AS.
Source
Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
Abstract
OBJECTIVE:
To determine the prevalence of preexisting antibodies against the pandemic 2009 Influenza A (H1N1) virus in pregnant women and to evaluate the seroprotection of the mothers and infants by a single injection of monovalent vaccine during the pandemic.
MATERIALS AND METHODS:
Seropositivity rate of H1N1 among the nonvaccinated were compared with the vaccinated women. A single dose of vaccine, either nonadjuvanted AdimFlu-S or MF59-adjuvanted vaccine, was injected to the voluntarily vaccinated group. Maternal and cord blood sera were collected to evaluate the antibody response of the H1N1 virus. Seropositivity was defined as a hemagglutination inhibition titer to H1N1 (A/Taiwan/126/09) ≥1:40.
RESULTS:
A total of 210 healthy, singleton, pregnant women were enrolled between January 2010 and May 2010. Seropositivity (≥1:40) of maternal hemagglutination inhibition was significantly higher in the vaccinated group (78%) than the nonvaccinated group (9.5%); 41.6% (20/48) of seropositive titers were >1:80. In nine vaccinated cases resulting in negative serum titers (<1:40), the prevalence of negative titer in the women received AdimFlu-S (14.8%, 4/31) was lower (p = 0.025) than those received MF59-adjuvanted vaccine (50%, 5/10).
CONCLUSIONS:
Subclinical infection against H1N1 was low in Taiwanese pregnant women in the pandemic 2009. Seropositivity >75% could be achieved in the paired maternal and cord serum samples by a single injection of monovalent H1N1 vaccine.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
H1N1, infant, influenza A, pregnancy, vaccine
PMID:
24075373
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24075373
Seroprevalence of influenza A H1N1 and seroconversion of mothers and infants induced by a single dose of monovalent vaccine.
Chao A, Huang YC, Chang YL, Wang TH, Chang SD, Wu TS, Wu TL, Chao AS.
Source
Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
Abstract
OBJECTIVE:
To determine the prevalence of preexisting antibodies against the pandemic 2009 Influenza A (H1N1) virus in pregnant women and to evaluate the seroprotection of the mothers and infants by a single injection of monovalent vaccine during the pandemic.
MATERIALS AND METHODS:
Seropositivity rate of H1N1 among the nonvaccinated were compared with the vaccinated women. A single dose of vaccine, either nonadjuvanted AdimFlu-S or MF59-adjuvanted vaccine, was injected to the voluntarily vaccinated group. Maternal and cord blood sera were collected to evaluate the antibody response of the H1N1 virus. Seropositivity was defined as a hemagglutination inhibition titer to H1N1 (A/Taiwan/126/09) ≥1:40.
RESULTS:
A total of 210 healthy, singleton, pregnant women were enrolled between January 2010 and May 2010. Seropositivity (≥1:40) of maternal hemagglutination inhibition was significantly higher in the vaccinated group (78%) than the nonvaccinated group (9.5%); 41.6% (20/48) of seropositive titers were >1:80. In nine vaccinated cases resulting in negative serum titers (<1:40), the prevalence of negative titer in the women received AdimFlu-S (14.8%, 4/31) was lower (p = 0.025) than those received MF59-adjuvanted vaccine (50%, 5/10).
CONCLUSIONS:
Subclinical infection against H1N1 was low in Taiwanese pregnant women in the pandemic 2009. Seropositivity >75% could be achieved in the paired maternal and cord serum samples by a single injection of monovalent H1N1 vaccine.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
H1N1, infant, influenza A, pregnancy, vaccine
PMID:
24075373
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24075373