Mary Wilson
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LETTER
Received: 21 November 2017 / Accepted: 8 January 2018
Ó Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018
https://doi.org/10.1007/s12250-018-0012-7
Ning Wang1,2 • Shi-Yue Li3 • Xing-Lou Yang1 • Hui-Min Huang3 • Yu-Ji Zhang1 • Hua Guo1,2 • Chu-Ming Luo1,2 •Maureen Miller4 • Guangjian Zhu4 • Aleksei A. Chmura4 • Emily Hagan4 • Ji-Hua Zhou5 • Yun-Zhi Zhang5,6 •Lin-Fa Wang7 • Peter Daszak4 • Zheng-Li Shi1
Dear Editor,
Severe acute respiratory syndrome coronavirus (SARS- CoV) is the causative agent of the 2002–2003 SARS pandemic, which resulted in more than 8000 human infections worldwide and an approximately 10% fatality rate (Ksiazek et al. 2003; Peiris et al. 2004). The virus infects both upper airway and alveolar epithelial cells, resulting in mild to severe lung injury in humans (Peiris et al. 2003).
During the SARS outbreak investigation, epidemiolog- ical evidence of a zoonotic origin of SARS-CoV was identified (Xu et al. 2004). Isolation of SARS-related coronavirus (SARSr-CoVs) from masked palm civets and the detection of SARS-CoV infection in humans working at wet markets where civets were sold suggested that masked palm civets could serve as a source of human infection (Guan et al. 2003). Subsequent work identified genetically diverse SARSr-CoVs in Chinese horseshoe bats (Rhinolo- phus sinicus) in a county of Yunnan Province, China and provided strong evidence that bats are the natural reservoir of SARS-CoV (Ge et al. 2013; Li et al. 2005; Yang et al.2016). Since then, diverse SARS-related coronaviruses (SARSr-CoVs) have been detected and reported in bats in different regions globally (Hu et al. 2015). Importantly, SARSr-CoVs that use the SARS-CoV receptor, angiotensin converting enzyme 2 (ACE2) have been isolated (Ge et al.2013). These results indicate that some SARSr-CoVs may have high potential to infect human cells, without the necessity for an intermediate host. However, to date, no evidence of direct transmission of SARSr-CoVs from bats to people has been reported.
In this study, we performed serological surveillance on people who live in close proximity to caves where bats that carry diverse SARSr-CoVs roost. In October 2015, we collected serum samples from 218 residents in four villages in Jinning County, Yunnan province, China (Fig. 1A), located 1.1–6.0 km from two caves (Yanzi and Shitou). We have been conducting longitudinal molecular surveillance of bats for CoVs in these caves since 2011 and have found that they are inhabited by large numbers of bats includingRhinolophus spp., a major reservoir of SARSr-CoVs. This region was not involved in the 2002–2003 SARS outbreaks and none of the subjects exhibited any evident respiratory illness during sampling.
...
https://www.ecohealthalliance.org/wp...nica-SARSr.pdf
Received: 21 November 2017 / Accepted: 8 January 2018
Ó Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018
https://doi.org/10.1007/s12250-018-0012-7
Ning Wang1,2 • Shi-Yue Li3 • Xing-Lou Yang1 • Hui-Min Huang3 • Yu-Ji Zhang1 • Hua Guo1,2 • Chu-Ming Luo1,2 •Maureen Miller4 • Guangjian Zhu4 • Aleksei A. Chmura4 • Emily Hagan4 • Ji-Hua Zhou5 • Yun-Zhi Zhang5,6 •Lin-Fa Wang7 • Peter Daszak4 • Zheng-Li Shi1
Dear Editor,
Severe acute respiratory syndrome coronavirus (SARS- CoV) is the causative agent of the 2002–2003 SARS pandemic, which resulted in more than 8000 human infections worldwide and an approximately 10% fatality rate (Ksiazek et al. 2003; Peiris et al. 2004). The virus infects both upper airway and alveolar epithelial cells, resulting in mild to severe lung injury in humans (Peiris et al. 2003).
During the SARS outbreak investigation, epidemiolog- ical evidence of a zoonotic origin of SARS-CoV was identified (Xu et al. 2004). Isolation of SARS-related coronavirus (SARSr-CoVs) from masked palm civets and the detection of SARS-CoV infection in humans working at wet markets where civets were sold suggested that masked palm civets could serve as a source of human infection (Guan et al. 2003). Subsequent work identified genetically diverse SARSr-CoVs in Chinese horseshoe bats (Rhinolo- phus sinicus) in a county of Yunnan Province, China and provided strong evidence that bats are the natural reservoir of SARS-CoV (Ge et al. 2013; Li et al. 2005; Yang et al.2016). Since then, diverse SARS-related coronaviruses (SARSr-CoVs) have been detected and reported in bats in different regions globally (Hu et al. 2015). Importantly, SARSr-CoVs that use the SARS-CoV receptor, angiotensin converting enzyme 2 (ACE2) have been isolated (Ge et al.2013). These results indicate that some SARSr-CoVs may have high potential to infect human cells, without the necessity for an intermediate host. However, to date, no evidence of direct transmission of SARSr-CoVs from bats to people has been reported.
In this study, we performed serological surveillance on people who live in close proximity to caves where bats that carry diverse SARSr-CoVs roost. In October 2015, we collected serum samples from 218 residents in four villages in Jinning County, Yunnan province, China (Fig. 1A), located 1.1–6.0 km from two caves (Yanzi and Shitou). We have been conducting longitudinal molecular surveillance of bats for CoVs in these caves since 2011 and have found that they are inhabited by large numbers of bats includingRhinolophus spp., a major reservoir of SARSr-CoVs. This region was not involved in the 2002–2003 SARS outbreaks and none of the subjects exhibited any evident respiratory illness during sampling.
...
https://www.ecohealthalliance.org/wp...nica-SARSr.pdf