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Source: http://7thspace.com/headlines/43229...ients_3_years_after_nifurtimox_treatment.html
Serological and parasitological response in chronic Chagas patients 3 years after nifurtimox treatment
With declining vectorial transmission, Chagas disease predominantly affects adults nowadays. The efficacy of nifurtimox in the chronic phase in adult patients is poorly known, particularly in regions where there is no risk of reinfection.
Recommendations for treatment outcome assessment rely on serological follow-up. We evaluated the serological and parasitological response to nifurtimox in a cohort of adult patients three years post-treatment in Switzerland...
...Conclusion: Our results highlight the inadequacy of serology for assessing response in adults, three years after treatment. In our cohort, 97.3% had results that could either indicate treatment failure or persistant humoral response despite treatment.
The lack of accurate early post-treatment tests of cure prevents appropriate patients information and councelling. New follow-up tests are needed to assess treatments efficacy given the large adult population in need of antiparasitic therapy.
Author: Yves JacksonEric ChatelainAnne MaurisMarylise HolstQianqian MiaoFrancois ChappuisMomar Ndao
Credits/Source: BMC Infectious Diseases 2013, 13:85
Published on: 2013-02-13
Serological and parasitological response in chronic Chagas patients 3 years after nifurtimox treatment
With declining vectorial transmission, Chagas disease predominantly affects adults nowadays. The efficacy of nifurtimox in the chronic phase in adult patients is poorly known, particularly in regions where there is no risk of reinfection.
Recommendations for treatment outcome assessment rely on serological follow-up. We evaluated the serological and parasitological response to nifurtimox in a cohort of adult patients three years post-treatment in Switzerland...
...Conclusion: Our results highlight the inadequacy of serology for assessing response in adults, three years after treatment. In our cohort, 97.3% had results that could either indicate treatment failure or persistant humoral response despite treatment.
The lack of accurate early post-treatment tests of cure prevents appropriate patients information and councelling. New follow-up tests are needed to assess treatments efficacy given the large adult population in need of antiparasitic therapy.
Author: Yves JacksonEric ChatelainAnne MaurisMarylise HolstQianqian MiaoFrancois ChappuisMomar Ndao
Credits/Source: BMC Infectious Diseases 2013, 13:85
Published on: 2013-02-13