tetano
Editor, Senior Moderator
Vaccine. 2011 Jul 12. [Epub ahead of print]
Seroepidemiological study of pandemic influenza H1N1 following the 2009-2010 wave in Greece.
Maltezou HC, Katerelos P, Mavrouli M, Lourida A, Routsias JG, Spanakis N, Maragos A, Tedoma A, Bassiakos Y, Koratzanis G, Mantagos S, Metallidis S, Katragkou A, Nikolaidis P, Roilides E, Theodoridou M, Tsakris A.
Source
Department for Interventions in Health-Care Facilities, Hellenic Center for Diseases, Control and Prevention, 3-5 Agrafon Street, Athens 15123, Greece.
Abstract
Knowledge of seroprevalence rates against 2009 pandemic H1N1 virus will assist vaccination recommendations and the preparation of the health-care system during subsequent years. This study was conducted in Greece during June-August 2010 to estimate the seroprevalence rate against pandemic H1N1 virus. Persons presenting in 29 health-care facilities across the country were studied. Seroprevalence was estimated employing a virus-free ELISA that specifically recognizes 2009 H1N1 virus antibodies in human sera. Sera collected from 2005 to April 2009 were also used to estimate pre-pandemic seroprevalence rates. A total of 954 persons were studied. The overall seroprevalence rate was 28.5% (95% confidence interval=25.6-31.3%). Age-specific rates were 34.2% in persons 0-4 years, 36.3% in persons 5-19 years, 25.0% in persons 20-39 years, 23.4% in persons 40-59 years, and 31.8% in persons ≥60 years. The highest rates were recorded in the Regions of Ionian Islands (67%) and Epirus (42.9%), while the lowest (8.4%) in the Region of Thessaly. Age-specific attack rates of infection during 2009-2010 were 28.8% in persons 0-4 years, 32.5% in persons 5-19 years, 14.3% in persons 20-39 years, 19.1% in persons 40-59 years, and 14.4% in persons ≥60 years. Multivariate analysis revealed that Region of residence and caring for children <5 years were associated with increased risk for seropositivity. Urbanity, personal and family characteristics, working in a health-care facility or in a school, history of pandemic H1N1 vaccination or history of influenza-like illness during 2009-2010 were not associated with increased risk for seropositivity.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
21762749
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21762749
Seroepidemiological study of pandemic influenza H1N1 following the 2009-2010 wave in Greece.
Maltezou HC, Katerelos P, Mavrouli M, Lourida A, Routsias JG, Spanakis N, Maragos A, Tedoma A, Bassiakos Y, Koratzanis G, Mantagos S, Metallidis S, Katragkou A, Nikolaidis P, Roilides E, Theodoridou M, Tsakris A.
Source
Department for Interventions in Health-Care Facilities, Hellenic Center for Diseases, Control and Prevention, 3-5 Agrafon Street, Athens 15123, Greece.
Abstract
Knowledge of seroprevalence rates against 2009 pandemic H1N1 virus will assist vaccination recommendations and the preparation of the health-care system during subsequent years. This study was conducted in Greece during June-August 2010 to estimate the seroprevalence rate against pandemic H1N1 virus. Persons presenting in 29 health-care facilities across the country were studied. Seroprevalence was estimated employing a virus-free ELISA that specifically recognizes 2009 H1N1 virus antibodies in human sera. Sera collected from 2005 to April 2009 were also used to estimate pre-pandemic seroprevalence rates. A total of 954 persons were studied. The overall seroprevalence rate was 28.5% (95% confidence interval=25.6-31.3%). Age-specific rates were 34.2% in persons 0-4 years, 36.3% in persons 5-19 years, 25.0% in persons 20-39 years, 23.4% in persons 40-59 years, and 31.8% in persons ≥60 years. The highest rates were recorded in the Regions of Ionian Islands (67%) and Epirus (42.9%), while the lowest (8.4%) in the Region of Thessaly. Age-specific attack rates of infection during 2009-2010 were 28.8% in persons 0-4 years, 32.5% in persons 5-19 years, 14.3% in persons 20-39 years, 19.1% in persons 40-59 years, and 14.4% in persons ≥60 years. Multivariate analysis revealed that Region of residence and caring for children <5 years were associated with increased risk for seropositivity. Urbanity, personal and family characteristics, working in a health-care facility or in a school, history of pandemic H1N1 vaccination or history of influenza-like illness during 2009-2010 were not associated with increased risk for seropositivity.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
21762749
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21762749