tetano
Editor, Senior Moderator
J Infect Dis. 2015 Aug 4. pii: jiv407. [Epub ahead of print]
[h=1]Sera from middle-aged adults vaccinated annually with seasonal influenza vaccines cross-neutralize some potential pandemic influenza viruses.[/h] Wang W[SUP]1[/SUP], Facundo EA[SUP]1[/SUP], Chen Q[SUP]1[/SUP], Anderson CM[SUP]2[/SUP], Scott D[SUP]2[/SUP], Vassell R[SUP]1[/SUP], Weiss CD[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We examined sera from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004-2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (> 160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/Hong Kong/SF4/01 (H6N1). None had titers>160 to A/Shanghai/2/13 (H7N9) or A/Netherlands/219/03 (H7N7). 36%-0% had neutralization titers to various H5N1 strains. Titers to H9, H6 and H5 HA-pseudoviruses correlated with each other, but not with H3N2v, suggesting group-specific cross-neutralization.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 26243315 [PubMed - as supplied by publisher]
[h=1]Sera from middle-aged adults vaccinated annually with seasonal influenza vaccines cross-neutralize some potential pandemic influenza viruses.[/h] Wang W[SUP]1[/SUP], Facundo EA[SUP]1[/SUP], Chen Q[SUP]1[/SUP], Anderson CM[SUP]2[/SUP], Scott D[SUP]2[/SUP], Vassell R[SUP]1[/SUP], Weiss CD[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We examined sera from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004-2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (> 160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/Hong Kong/SF4/01 (H6N1). None had titers>160 to A/Shanghai/2/13 (H7N9) or A/Netherlands/219/03 (H7N7). 36%-0% had neutralization titers to various H5N1 strains. Titers to H9, H6 and H5 HA-pseudoviruses correlated with each other, but not with H3N2v, suggesting group-specific cross-neutralization.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 26243315 [PubMed - as supplied by publisher]