tetano
Editor, Senior Moderator
J Clin Microbiol. 2010 Jun 16. [Epub ahead of print]
Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses.
Sakai-Tagawa Y, Ozawa M, Tamura D, Le QM, Nidom CA, Sugaya N, Kawaoka Y.
Division of Virology, Department of Microbiology and Immunology, and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639; Department of Pediatrics, Keiyu Hospital, Yokohama 220-0012; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012; Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Faculty of Veterinary Medicine, Tropical Disease Centre, Airlangga University, Surabaya, Indonesia; and Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.
Abstract
Simple and rapid diagnosis of influenza is useful to treatment decision-making in the clinical setting. Although many influenza rapid diagnostic tests (IRDTs) are available for the detection of seasonal influenza virus infections, their sensitivity for other viruses, such as H5N1 viruses and the recently emerged swine-origin pandemic (H1N1) 2009 virus, remains largely unknown. Here, we examined the sensitivity of 20 IRDTs to various influenza virus strains, including H5N1 and 2009 pandemic H1N1 viruses. Our results indicate that the detection sensitivity to swine-origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.
PMID: 20554831 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20554831
Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses.
Sakai-Tagawa Y, Ozawa M, Tamura D, Le QM, Nidom CA, Sugaya N, Kawaoka Y.
Division of Virology, Department of Microbiology and Immunology, and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639; Department of Pediatrics, Keiyu Hospital, Yokohama 220-0012; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012; Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Faculty of Veterinary Medicine, Tropical Disease Centre, Airlangga University, Surabaya, Indonesia; and Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.
Abstract
Simple and rapid diagnosis of influenza is useful to treatment decision-making in the clinical setting. Although many influenza rapid diagnostic tests (IRDTs) are available for the detection of seasonal influenza virus infections, their sensitivity for other viruses, such as H5N1 viruses and the recently emerged swine-origin pandemic (H1N1) 2009 virus, remains largely unknown. Here, we examined the sensitivity of 20 IRDTs to various influenza virus strains, including H5N1 and 2009 pandemic H1N1 viruses. Our results indicate that the detection sensitivity to swine-origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.
PMID: 20554831 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20554831