tetano
Editor, Senior Moderator
Bioorg Med Chem Lett. 2014 Jun 16. pii: S0960-894X(14)00646-5. doi: 10.1016/j.bmcl.2014.06.018. [Epub ahead of print]
Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: Synthesis and antiviral studies.
Bereczki I1, Kics?k M1, Dobray L1, Borb?s A1, Batta G2, K?ki S3, Nikod?m EN4, Ostorh?zi E4, Rozgonyi F4, Vanderlinden E5, Naesens L6, Herczegh P7.
Author information
Abstract
In order to obtain new, cluster-forming antibiotic compounds, teicoplanin pseudoaglycone derivatives containing two lipophilic n-octyl chains have been synthesized. The compounds proved to be poor antibacterials, but, surprisingly, they exhibited potent anti-influenza virus activity against influenza A strains. This antiviral action was related to inhibition of the binding interaction between the virus and the host cell. Related analogs bearing methyl substituents in lieu of the octyl chains, displayed no anti-influenza virus activity. Hence, an interaction between the active, dually n-octylated compounds and the lipid bilayer of the host cell can be postulated, to explain the observed inhibition of influenza virus attachment.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Aggregation; Influenza virus binding inhibitor; Lipophilic substituents; Teicoplanin pseudoaglycone
PMID:
24974341
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24974341
Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: Synthesis and antiviral studies.
Bereczki I1, Kics?k M1, Dobray L1, Borb?s A1, Batta G2, K?ki S3, Nikod?m EN4, Ostorh?zi E4, Rozgonyi F4, Vanderlinden E5, Naesens L6, Herczegh P7.
Author information
Abstract
In order to obtain new, cluster-forming antibiotic compounds, teicoplanin pseudoaglycone derivatives containing two lipophilic n-octyl chains have been synthesized. The compounds proved to be poor antibacterials, but, surprisingly, they exhibited potent anti-influenza virus activity against influenza A strains. This antiviral action was related to inhibition of the binding interaction between the virus and the host cell. Related analogs bearing methyl substituents in lieu of the octyl chains, displayed no anti-influenza virus activity. Hence, an interaction between the active, dually n-octylated compounds and the lipid bilayer of the host cell can be postulated, to explain the observed inhibition of influenza virus attachment.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Aggregation; Influenza virus binding inhibitor; Lipophilic substituents; Teicoplanin pseudoaglycone
PMID:
24974341
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24974341