tetano
Editor, Senior Moderator
Semin Thromb Hemost
. 2025 May 23.
doi: 10.1055/a-2619-2485. Online ahead of print. Coagulation abnormalities associated with COVID-19: a narrative review
Massimo Franchini[SUP] 1 [/SUP], Daniele Focosi[SUP] 2 [/SUP], Pier Mannuccio Mannucci[SUP] 3 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by severe acute respiratory disease coronavirus 2 (SARS-COV-2), has caused in the last five years a global pandemic of unprecedented scale in the modern era. Other than the typical respiratory symptoms, patients suffering from moderate to severe COVID-19 are at risk of developing a peculiar systemic coagulopathy, known as COVID-19-associated coagulopathy. In addition to a predominantly hypercoagulable state, COVID-19 patients may experience hemorrhagic complications triggered by the viral infection. The current knowledge on the underlying molecular mechanisms, the laboratory and clinical characteristics of coagulation abnormalities associated with COVID-19, along with their management, will be summarized in this narrative review.
. 2025 May 23.
doi: 10.1055/a-2619-2485. Online ahead of print. Coagulation abnormalities associated with COVID-19: a narrative review
Massimo Franchini[SUP] 1 [/SUP], Daniele Focosi[SUP] 2 [/SUP], Pier Mannuccio Mannucci[SUP] 3 [/SUP]
Affiliations
- PMID: 40409294
- DOI: 10.1055/a-2619-2485
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by severe acute respiratory disease coronavirus 2 (SARS-COV-2), has caused in the last five years a global pandemic of unprecedented scale in the modern era. Other than the typical respiratory symptoms, patients suffering from moderate to severe COVID-19 are at risk of developing a peculiar systemic coagulopathy, known as COVID-19-associated coagulopathy. In addition to a predominantly hypercoagulable state, COVID-19 patients may experience hemorrhagic complications triggered by the viral infection. The current knowledge on the underlying molecular mechanisms, the laboratory and clinical characteristics of coagulation abnormalities associated with COVID-19, along with their management, will be summarized in this narrative review.