tetano
Editor, Senior Moderator
Semin Liver Dis
. 2022 May;42(2):151-158.
doi: 10.1055/s-0042-1745871. Epub 2022 Jun 23.
Liver Dysfunction in COVID-19: From Onset to Recovery
Wen-Zheng Yuan[SUP] 1 [/SUP], Tao Fu[SUP] 1 [/SUP]
Affiliations
Abstract
With the spread of coronavirus disease 2019 (COVID-19) worldwide, extrapulmonary lesions, including liver dysfunction, have attracted growing attention. The mechanisms underlying liver dysfunction in COVID-19 remain unclear. The reported prevalence of liver dysfunction varies widely across studies. In addition, its impact on clinical outcomes and its recovery after discharge are still controversial. In this review, pathological and laboratory findings were analyzed to reveal the potential mechanisms of COVID-19-induced liver injury from onset to recovery. Four patterns of liver damage were summarized according to the pathological findings, including hypoxemia and shock changes, vascular thrombosis and vascular damage, bile duct damage, and other histological changes. With a strict definition, the prevalence of liver dysfunction was not as high as reported. Meanwhile, liver dysfunction improved during the process of recovery. Nevertheless, the definite liver dysfunction was significantly associated with severe clinical course, which should not be ignored.
. 2022 May;42(2):151-158.
doi: 10.1055/s-0042-1745871. Epub 2022 Jun 23.
Liver Dysfunction in COVID-19: From Onset to Recovery
Wen-Zheng Yuan[SUP] 1 [/SUP], Tao Fu[SUP] 1 [/SUP]
Affiliations
- PMID: 35738256
- DOI: 10.1055/s-0042-1745871
Abstract
With the spread of coronavirus disease 2019 (COVID-19) worldwide, extrapulmonary lesions, including liver dysfunction, have attracted growing attention. The mechanisms underlying liver dysfunction in COVID-19 remain unclear. The reported prevalence of liver dysfunction varies widely across studies. In addition, its impact on clinical outcomes and its recovery after discharge are still controversial. In this review, pathological and laboratory findings were analyzed to reveal the potential mechanisms of COVID-19-induced liver injury from onset to recovery. Four patterns of liver damage were summarized according to the pathological findings, including hypoxemia and shock changes, vascular thrombosis and vascular damage, bile duct damage, and other histological changes. With a strict definition, the prevalence of liver dysfunction was not as high as reported. Meanwhile, liver dysfunction improved during the process of recovery. Nevertheless, the definite liver dysfunction was significantly associated with severe clinical course, which should not be ignored.