tetano
Editor, Senior Moderator
Trends Microbiol. 2014 May 2. pii: S0966-842X(14)00072-9. doi: 10.1016/j.tim.2014.04.001. [Epub ahead of print]
Selective packaging of the influenza A genome and consequences for genetic reassortment.
Gerber M1, Isel C1, Moules V2, Marquet R3.
Author information
Abstract
Influenza A viruses package their segmented RNA genome in a selective manner. Electron tomography, biochemical assays, and replication assays of viruses produced by reverse genetics recently unveiled molecular details of this mechanism, whereby different influenza viral strains form different and unique networks of direct intermolecular RNA-RNA interactions. Together with detailed views of the three-dimensional structure of the viral ribonucleoparticles, these recent advances help us understand the rules that govern genome packaging. They also have deep implications for the genetic reassortment processes, which are responsible for devastating pandemics.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
RNA?RNA interactions, genetic reassortment, influenza A virus, packaging, supramolecular complex
PMID:
24798745
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24798745
Selective packaging of the influenza A genome and consequences for genetic reassortment.
Gerber M1, Isel C1, Moules V2, Marquet R3.
Author information
Abstract
Influenza A viruses package their segmented RNA genome in a selective manner. Electron tomography, biochemical assays, and replication assays of viruses produced by reverse genetics recently unveiled molecular details of this mechanism, whereby different influenza viral strains form different and unique networks of direct intermolecular RNA-RNA interactions. Together with detailed views of the three-dimensional structure of the viral ribonucleoparticles, these recent advances help us understand the rules that govern genome packaging. They also have deep implications for the genetic reassortment processes, which are responsible for devastating pandemics.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
RNA?RNA interactions, genetic reassortment, influenza A virus, packaging, supramolecular complex
PMID:
24798745
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24798745