tetano
Editor, Senior Moderator
Sci Transl Med. 2014 Jul 23;6(246):246ps8.
Seeking Help: B Cells Adapting to Flu Variability.
van der Most RG1, Roman FP2, Innis B3, Hanon E2, Vaughn DW2, Gillard P2, Walravens K2, Wettendorff M2.
Author information
Abstract
The study of influenza vaccines has revealed potential interactions between preexisting immunological memory and antigenic context and/or adjuvantation. In the face of antigenic diversity, the process of generating B cell adaptability is driven by cross-reactive CD4 memory cells, such as T follicular helper cells from previous infections or vaccinations. Although such "helped" B cells are capable of adapting to variant antigens, lack of CD4 help could lead to a suboptimal antibody response. Collectively, this indicates an interplay between CD4 T cells, adjuvant, and B cell adaptability.
Copyright ? 2014, American Association for the Advancement of Science.
PMID:
25101885
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25101885
Seeking Help: B Cells Adapting to Flu Variability.
van der Most RG1, Roman FP2, Innis B3, Hanon E2, Vaughn DW2, Gillard P2, Walravens K2, Wettendorff M2.
Author information
Abstract
The study of influenza vaccines has revealed potential interactions between preexisting immunological memory and antigenic context and/or adjuvantation. In the face of antigenic diversity, the process of generating B cell adaptability is driven by cross-reactive CD4 memory cells, such as T follicular helper cells from previous infections or vaccinations. Although such "helped" B cells are capable of adapting to variant antigens, lack of CD4 help could lead to a suboptimal antibody response. Collectively, this indicates an interplay between CD4 T cells, adjuvant, and B cell adaptability.
Copyright ? 2014, American Association for the Advancement of Science.
PMID:
25101885
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25101885