tetano
Editor, Senior Moderator
RMD Open. 2019 Sep 3;5(2):e001018. doi: 10.1136/rmdopen-2019-001018. eCollection 2019. [h=1]Secukinumab does not impair the immunogenic response to the influenza vaccine in patients.[/h]
Richi P[SUP]1,[/SUP][SUP]2[/SUP], Mart?n MD[SUP]3[/SUP], de Ory F[SUP]4[/SUP], Guti?rrez-Larraya R[SUP]2[/SUP], Casas I[SUP]5[/SUP], Jim?nez-D?az AM[SUP]1[/SUP], Cava F[SUP]6[/SUP], Mu?oz-Fernandez S[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h] 1 Rheumatology Department, Infanta Sof?a University Hospital, San Sebastian de los Reyes, Spain. 2 School of Medicine, European University of Madrid, Madrid, Spain. 3 Bactereology Department, BR Salud Laboratories, San Sebastian de los Reyes, Spain. 4 National Microbiology Centre, CIBER-ESP, Instituto de Salud Carlos III, Majadahonda, Spain. 5 National Microbiology Centre, Instituto de Salud Carlos III Campus de Majadahonda, Majadahonda, Spain. 6 BR Salud Laboratories, San Sebastian de los Reyes, Spain.
[h=3]Abstract[/h] [h=4]Objective:[/h] To evaluate whether immunological response to influenza vaccination is impaired in patients who are receiving secukinumab.
[h=4]Patients and methods:[/h] Subjects suffering from psoriatic arthritis or ankylosing spondylitis who were receiving treatment with secukinumab and healthy volunteers were included.All participants received seasonal inactivated trivalent influenza vaccine recommended by the WHO in the 2017-2018 northern hemisphere influenza season, which contained an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Hong Kong/4801/2014 (H3N2)-like virus and a B/Brisbane/60/2008-like virus.Haemagglutination inhibition was used to evaluate basal antibody (Ab) titres against the three influenza vaccine virus strains just before vaccination and at least 4 weeks after the vaccine administration. Response to vaccine was considered as >4-fold increases in Ab titre.
[h=4]Results:[/h] Thirty subjects, 17 patients and 13 healthy controls, with a follow-up duration of 33?8 days, were analysed. There were no demographic differences between groups. Patients and controls achieved a median of 4.6-fold and 4.0-fold increases, respectively, for anti H1N1 and almost 4.0 (3.7) for patients and 5.3 for controls for anti-B Ab. Both groups presented a poor response against H3N2, with <1.5-fold increase. Seroconversion rates were similar in both groups. Secukinumab did not influence the response to the influenza vaccine (relative risk: 1.09 (95% CI 0.58 to 2.07) for H1N1, RR: 1.53 (95% CI 0.15 to 15.0) for H3N2 and RR: 0.72 (95% CI 0.32 to 1.83) for B strain).
[h=4]Conclusion:[/h] In our study, secukinumab has no effect on the immunogenic response to the influenza vaccine.
? Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
[h=4]KEYWORDS:[/h] Ankylosing Spondylitis; DMARDs (biologic); psoriatic arthritis; vaccination
PMID: 31565246 PMCID: PMC6744077 DOI: 10.1136/rmdopen-2019-001018
Richi P[SUP]1,[/SUP][SUP]2[/SUP], Mart?n MD[SUP]3[/SUP], de Ory F[SUP]4[/SUP], Guti?rrez-Larraya R[SUP]2[/SUP], Casas I[SUP]5[/SUP], Jim?nez-D?az AM[SUP]1[/SUP], Cava F[SUP]6[/SUP], Mu?oz-Fernandez S[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h] 1 Rheumatology Department, Infanta Sof?a University Hospital, San Sebastian de los Reyes, Spain. 2 School of Medicine, European University of Madrid, Madrid, Spain. 3 Bactereology Department, BR Salud Laboratories, San Sebastian de los Reyes, Spain. 4 National Microbiology Centre, CIBER-ESP, Instituto de Salud Carlos III, Majadahonda, Spain. 5 National Microbiology Centre, Instituto de Salud Carlos III Campus de Majadahonda, Majadahonda, Spain. 6 BR Salud Laboratories, San Sebastian de los Reyes, Spain.
[h=3]Abstract[/h] [h=4]Objective:[/h] To evaluate whether immunological response to influenza vaccination is impaired in patients who are receiving secukinumab.
[h=4]Patients and methods:[/h] Subjects suffering from psoriatic arthritis or ankylosing spondylitis who were receiving treatment with secukinumab and healthy volunteers were included.All participants received seasonal inactivated trivalent influenza vaccine recommended by the WHO in the 2017-2018 northern hemisphere influenza season, which contained an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Hong Kong/4801/2014 (H3N2)-like virus and a B/Brisbane/60/2008-like virus.Haemagglutination inhibition was used to evaluate basal antibody (Ab) titres against the three influenza vaccine virus strains just before vaccination and at least 4 weeks after the vaccine administration. Response to vaccine was considered as >4-fold increases in Ab titre.
[h=4]Results:[/h] Thirty subjects, 17 patients and 13 healthy controls, with a follow-up duration of 33?8 days, were analysed. There were no demographic differences between groups. Patients and controls achieved a median of 4.6-fold and 4.0-fold increases, respectively, for anti H1N1 and almost 4.0 (3.7) for patients and 5.3 for controls for anti-B Ab. Both groups presented a poor response against H3N2, with <1.5-fold increase. Seroconversion rates were similar in both groups. Secukinumab did not influence the response to the influenza vaccine (relative risk: 1.09 (95% CI 0.58 to 2.07) for H1N1, RR: 1.53 (95% CI 0.15 to 15.0) for H3N2 and RR: 0.72 (95% CI 0.32 to 1.83) for B strain).
[h=4]Conclusion:[/h] In our study, secukinumab has no effect on the immunogenic response to the influenza vaccine.
? Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
[h=4]KEYWORDS:[/h] Ankylosing Spondylitis; DMARDs (biologic); psoriatic arthritis; vaccination
PMID: 31565246 PMCID: PMC6744077 DOI: 10.1136/rmdopen-2019-001018