gsgs
Registered User
1: J Med Virol. 2008 Sep 23;80(11):1992-1996. [Epub ahead of print]
Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans.Tang JW, Ngai KL, Chan PK.
Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
In a small pilot study, sera from 10 healthy human volunteers were taken pre-vaccine, then 1, 3, and 6 months post-seasonal influenza immunization (using the 2005/2006 Northern hemisphere vaccine: A/New Caledonia/20/99(H1N1)-like, A/California/7/2004(H3N2)-like, and B/Shanghai/361/2002-like strains). Eight out of 10 subjects demonstrated satisfactory HAI titers (>/=40) after seasonal influenza vaccination between 1 and 6 months post-vaccine. These sera were then tested for inhibitory activity against A/HK/483/97 and A/Thailand/1(KAN-1)/04 H5N1 influenza viruses using standard hemagglutination inhibition and microneutralization assays. In contrast to several other studies in both humans and animals on the cross-immunity between different influenza A viruses, antibodies produced to the influenza A(H1N1) component of the seasonal influenza vaccine showed no cross-reactivity to these avian influenza A(H5N1) viruses. Possible reasons for this contrasting result are discussed. J. Med. Virol. 80:1992-1996, 2008. (c) 2008 Wiley-Liss, Inc.
PMID: 18814271 [PubMed - as supplied by publisher]
Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans.Tang JW, Ngai KL, Chan PK.
Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
In a small pilot study, sera from 10 healthy human volunteers were taken pre-vaccine, then 1, 3, and 6 months post-seasonal influenza immunization (using the 2005/2006 Northern hemisphere vaccine: A/New Caledonia/20/99(H1N1)-like, A/California/7/2004(H3N2)-like, and B/Shanghai/361/2002-like strains). Eight out of 10 subjects demonstrated satisfactory HAI titers (>/=40) after seasonal influenza vaccination between 1 and 6 months post-vaccine. These sera were then tested for inhibitory activity against A/HK/483/97 and A/Thailand/1(KAN-1)/04 H5N1 influenza viruses using standard hemagglutination inhibition and microneutralization assays. In contrast to several other studies in both humans and animals on the cross-immunity between different influenza A viruses, antibodies produced to the influenza A(H1N1) component of the seasonal influenza vaccine showed no cross-reactivity to these avian influenza A(H5N1) viruses. Possible reasons for this contrasting result are discussed. J. Med. Virol. 80:1992-1996, 2008. (c) 2008 Wiley-Liss, Inc.
PMID: 18814271 [PubMed - as supplied by publisher]
