Seasonal influenza vaccine helps prevent AH1N1

[Shiloh]

Source: http://www.canalrcn.com/noticias/in...ntra-gripe-estacional-ayuda-a-prevenir-ah1n1/

Google translation:


National

Seasonal influenza vaccine helps prevent AH1N1
Vaccine against seasonal flu vaccine helps prevent AH1N1La costs between 30 thousand and 40 thousand pesos

Bogot?, Colombia (RCN) - The increase in positive cases of H1N1 virus in our country, experts recommend vaccination against seasonal flu or influenza.

"Studies have shown that only 33 percent of those vaccinated have any protection. Well something is, but especially to prevent a single person in the pool and the new vaccine, the AH1N1. Then comes another monster, "said Carlos Jaramillo, infectologists and virologist

Specialists in the field say that influenza is a serious illness. Temperatures above 38 degrees, cough with phlegm, shortness of breath and blue lips or fingernails are a cause for alarm. Vaccine reduced the risk of acute respiratory diseases.

"The vaccine for children is applied not to become infected and not die. In children it works very well, as in young adults. But older adults the vaccine is applied in order not to die, "said virologist infectologists and Carlos Jaramillo.

The Ministry of Social Protection is available in the various health agencies influenza vaccines. Apply for free to children 6 to 23 months and older than 60 years. Others may purchase the EPS and has a value of 30 thousand to 40 thousand pesos.

Deaths

Of the 8 deaths that have so far related to respiratory infection, four were discarded by AH1N1, two confirmed and two are under investigation. One is a 30 year old woman who was pregnant, but according to preliminary tests did not have the virus. The other case in this study. Is that of a 19-year-old who died in Santa Marta the weekend.

The authorities reiterated that following the confirmation of two deaths from the virus AH1N1 in the country, should further strengthen security measures at home and in hospitals

"Between 90 and 95 per cent of cases, can be regarded as mild and patients go ahead with measures such as hydration, nutrition, rest and in case of fever: acetaminophen," said Juan Gonzalo Lopez, director of the National Institute of Health .

The director also asked the INS to do an EPS close monitoring of patients with acute respiratory infection, to prevent more deaths in the country. So far there are 71 confirmed cases across the country by AH1N1.

 

[tropical]

Re: Seasonal influenza vaccine helps prevent AH1N1

#1: "Seasonal influenza vaccine helps prevent AH1N1"

Seems as internal foging only ...

From previous sci posts such help were negated!(?)

 

[AlaskaDenise]

Re: Seasonal influenza vaccine helps prevent AH1N1

They may be referencing the process whereby recent immunizations/infections of poultry with one influenza strain can "prime" their immune system for protection against other strains.

It's my good 4-year-old HK poultry story - a recent H9N2 infection protected a flock of geese against a H5N1 outbreak in the community. In poultry, that immune-stimiulating factor declines with time, being lost by day 100. I've long advocated that should someone know they'll be exposed to H5N1, a vaccination with any flu vaccine, 10+ days prior to expected exposure, may provide the needed "priming" of their immune system so they will receive some protection.

See: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=136145

Protective Cross-Reactive Cellular Immunity to Lethal A/Goose/Guangdong/1/96-Like H5N1 Influenza Virus Is Correlated with the Proportion of Pulmonary CD8+ T Cells Expressing Gamma Interferon

Abstract

A/Goose/Guangdong/1/96-like H5N1 influenza viruses now circulating in southeastern China differ genetically from the H5N1 viruses transmitted to humans in 1997 but were their precursors. Here we show that the currently circulating H9N2 influenza viruses provide chickens with cross-reactive protective immunity against the currently circulating H5N1 influenza viruses and that this protective immunity is closely related to the percentage of pulmonary CD8+ T cells expressing gamma interferon (IFN-γ). In vivo depletion of T-cell subsets showed that the cross-reactive immunity was mediated by T cells bearing CD8+ and T-cell receptor (TCR) α/β and that the Vβ1 subset of TCR α/β T cells had a dominant role in protective immunity. The protective immunity induced by infection with H9N2 virus declined with time, lasting as long as 100 days after immunization. Shedding of A/Goose/Guangdong/1/96-like H5N1 virus by immunized chickens also increased with the passage of time and thus may play a role in the perpetuation and spread of these highly pathogenic H5N1 influenza viruses. Our findings indicate that pulmonary cellular immunity may be very important in protecting naïve natural hosts against lethal influenza viruses.

(snipped)

DISCUSSION

We have shown that inoculation with circulating H9N2 influenza virus provides cross-protective immunity to circulating A/Goose/Guangdong/1/96-like H5N1 influenza virus. Although the immunized chickens were protected, most of the chickens shed virus tracheally and cloacally. Such shedding may perpetuate and spread the lethal H5N1 viruses in poultry in the Hong Kong bird markets. We also found that CD8+ T cells or TCR α/β (Vβ1) T cells, rather than TCR γ/δ T cells, protected these natural hosts of influenza virus from lethal H5N1 influenza in the absence of neutralizing antibody. The protective immunity lasted as long as 100 days.

.....(last paragraph)

Cross-reactive cellular immunity seems to have two important potential consequences: the protection of hosts from disease and the perpetuation of viruses in these hosts. Some protected chickens shed H5N1 viruses in their tracheae and cloacae. H9N2 viruses similar to A/Chicken/HK/SF3/99 are endemic in chickens in southeastern China (18), and while this prior immunity may mask the pathogenicity of subsequent H5N1 infections, it does not completely suppress infection. Replication of H5N1 virus in H9N2-immunized chickens may provide an opportunity for reassortment between A/Goose/Guangdong/1/96-like viruses and other endemic avian viruses in the Hong Kong bird markets, thus increasing the odds that more virulent H5N1 viruses will emerge. The outbreaks of H5N1 viruses in Hong Kong poultry markets in 2001 support this premise. The isolates from these outbreaks are reported to be multiple reassortant viruses between A/Goose/Guangdong/1/96-like H5N1 viruses and other avian viruses endemic to southeastern Asia (personal communication with Y. Guan).

We are now conducting a study of cross-reactive protection against H5N1 influenza viruses isolated from poultry during outbreaks in Hong Kong in 2001. In conclusion, our findings demonstrate that memory CD8+ T cells and TCR α/β T cells primed by exposure to H9N2 influenza virus are key elements in cross-reactive immune control of the highly pathogenic H5N1 influenza virus in chickens and that protective immunity is correlated with the percentage of memory CD8+ T cells expressing IFN-γ in the lungs.

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[tropical]

Re: Seasonal influenza vaccine helps prevent AH1N1

A.D., #3


I can't dig out the various posts, but there were statements about that such previous seasonal flu vaccination did not spared the ones.

Exists some scientifical WHO/CDC/... firm standpoint about such news text claim?

If such cross-shielding is measurable, why all those worldwide places filled with flu did not start vaccinations with remaining past season flu jabs?

And more important, many places where the new flu roaming, freshly goes out from their's seasonal flu seasons, so were stil protected by the vaccine, and stil had experienced the new flu.

Any of the health bodies in the mass afected countries did verify, compile, and comprove that the most of the new flu infected ones were not vaccinated to the past seasonal flus?

 

[AlaskaDenise]

Re: Seasonal influenza vaccine helps prevent AH1N1

I believe it's a timing issue - to get the helpful immune response, the exposure/vaccination must be within a very small window prior to new exposure. Vaccines administered months ago wouldn't have that effect. That would be logistically difficult - can you imagine trying to vaccinate everyone only 10 days prior to exposure? There have been no similar studies on humans & most of the public wants a "silver bullet" - a 100% solution with no effort.

Perhaps some of our members who have authored more recent relevent papers could comment on this one, both in light of more current research & as it might apply to humans.

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[AlaskaDenise]

Re: Seasonal influenza vaccine helps prevent AH1N1

I didn't add the date of the paper:

J Virol. 2002 May; 76(10):

Copyright ? 2002, American Society for Microbiology

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