tetano
Editor, Senior Moderator
Vaccine. 2013 Dec 23. pii: S0264-410X(13)01752-0. doi: 10.1016/j.vaccine.2013.12.021. [Epub ahead of print]
Seasonal influenza vaccine effectiveness against influenza in 2012-2013: A hospital-based case-control study in Lithuania.
Gefenaite G1, Rahamat-Langendoen J2, Ambrozaitis A3, Mickiene A4, Jancoriene L3, Kuliese M4, Velyvyte D4, Niesters H2, Stolk RP5, Zagminas K6, Hak E7.
Author information
Abstract
BACKGROUND:
Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season.
METHODS:
We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using multivariate logistic regression as (1-OR)?100%.
RESULTS:
The sample consisted of 185 subjects. Seasonal influenza vaccine uptake was 5%. Among 111 (60%) influenza positive cases, 24.3% were A(H1N1), 10.8% were A(H3) and 24.3% were influenza B cases. Unadjusted SIVE was 79% (95% CI -6% to 96%) and after the adjustment it increased to 86% (95% CI 19% to 97%).
CONCLUSIONS:
Seasonal influenza vaccination in 2012-2013 was associated with reduced occurrence of laboratory-confirmed influenza, but due to low sample size the estimate of SIVE is imprecise. Given high prevalence of influenza in hospitalized ILI cases and low influenza vaccination coverage, there is a need to increase influenza vaccination rates.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Case-control studies, Effectiveness, Influenza, Influenza vaccine, Lithuania
PMID:
24370711
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24370711
Seasonal influenza vaccine effectiveness against influenza in 2012-2013: A hospital-based case-control study in Lithuania.
Gefenaite G1, Rahamat-Langendoen J2, Ambrozaitis A3, Mickiene A4, Jancoriene L3, Kuliese M4, Velyvyte D4, Niesters H2, Stolk RP5, Zagminas K6, Hak E7.
Author information
Abstract
BACKGROUND:
Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season.
METHODS:
We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using multivariate logistic regression as (1-OR)?100%.
RESULTS:
The sample consisted of 185 subjects. Seasonal influenza vaccine uptake was 5%. Among 111 (60%) influenza positive cases, 24.3% were A(H1N1), 10.8% were A(H3) and 24.3% were influenza B cases. Unadjusted SIVE was 79% (95% CI -6% to 96%) and after the adjustment it increased to 86% (95% CI 19% to 97%).
CONCLUSIONS:
Seasonal influenza vaccination in 2012-2013 was associated with reduced occurrence of laboratory-confirmed influenza, but due to low sample size the estimate of SIVE is imprecise. Given high prevalence of influenza in hospitalized ILI cases and low influenza vaccination coverage, there is a need to increase influenza vaccination rates.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Case-control studies, Effectiveness, Influenza, Influenza vaccine, Lithuania
PMID:
24370711
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24370711