tetano
Editor, Senior Moderator
J Infect Dis. 2014 Dec 9. pii: jiu662. [Epub ahead of print]
Seasonal influenza can poise hosts for CD4 T cell immunity to H7N9 avian influenza.
Richards KA1, Nayak J2, Chaves FA1, DiPiazza A1, Knowlden ZA1, Alam S1, Treanor JJ3, Sant AJ4.
Author information
Abstract
The emergence of avian H7N9 viruses has raised concerns about its pandemic potential and prompted vaccine trials. At present, it is unknown whether there will be sufficient cross reactive HA-specific CD4 T cell memory with seasonal influenza to facilitate antibody production to H7-HA. There has also been the speculation that H7N9 will have few CD4 T cell epitopes. In this study, the potential of seasonal influenza to provide memory CD4 T cells that can cross-reactively recognize H7-HA derived peptides has been quantified. These studies have revealed that many humans have substantial H7 reactive CD4 T cells, while up to 40% are lacking such reactivity. Correlation studies indicate that CD4 T cells reactive with H7-HA are drawn from reactivity generated from seasonal strains. Overall, our studies suggest previous exposure of humans to seasonal influenza can poise them to respond to avian H7N9 but this is likely to be uneven across populations.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25492919
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25492919
Seasonal influenza can poise hosts for CD4 T cell immunity to H7N9 avian influenza.
Richards KA1, Nayak J2, Chaves FA1, DiPiazza A1, Knowlden ZA1, Alam S1, Treanor JJ3, Sant AJ4.
Author information
Abstract
The emergence of avian H7N9 viruses has raised concerns about its pandemic potential and prompted vaccine trials. At present, it is unknown whether there will be sufficient cross reactive HA-specific CD4 T cell memory with seasonal influenza to facilitate antibody production to H7-HA. There has also been the speculation that H7N9 will have few CD4 T cell epitopes. In this study, the potential of seasonal influenza to provide memory CD4 T cells that can cross-reactively recognize H7-HA derived peptides has been quantified. These studies have revealed that many humans have substantial H7 reactive CD4 T cells, while up to 40% are lacking such reactivity. Correlation studies indicate that CD4 T cells reactive with H7-HA are drawn from reactivity generated from seasonal strains. Overall, our studies suggest previous exposure of humans to seasonal influenza can poise them to respond to avian H7N9 but this is likely to be uneven across populations.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25492919
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25492919