tetano
Editor, Senior Moderator
J Med Virol. 2016 May 7. doi: 10.1002/jmv.24572. [Epub ahead of print]
[h=1]Seasonal influenza A/H3N2 virus infection and IL-1Β, IL-10, IL-17 and IL-28 polymorphisms in Iranian population.[/h] Rogo LD[SUP]1,[/SUP][SUP]2[/SUP], Rezaei F[SUP]1,[/SUP][SUP]3[/SUP], Marashi SM[SUP]1[/SUP], Yekaninejad MS[SUP]4[/SUP], Naseri M[SUP]1,[/SUP][SUP]3[/SUP], Ghavami N[SUP]1,[/SUP][SUP]3[/SUP], Mokhtari-Azad T[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Increased blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A/H3N2 virus infection. The study was aimed to investigate the polymorphisms of IL-1β, IL-10, IL-17 and IL-28 genes to find the possibility of their association with the clinical outcome of influenza A/H3N2 virus infection among the infected patients in Iran. This is a Case-Control study in which influenza A/H3N2 virus positive confirmed with real time PCR were the cases. DNA samples from groups were genotyped for polymorphisms in rs16944 (IL-1β), rs1800872 (IL-10), rs2275913 (IL-17) and rs8099917 (IL-28). Confidence interval (95% CI) and Odds ratio (OR) were calculated. IL-17 rs2275913 (GG and AG) were associated with risk of infection with that were statistically significant (p< 0.05, OR = 2.08-2.94). IL-1β (rs16944) (GG) was associated with reduced risk of infection (p < 0.01, OR = 0.46). Genotype GG and GT of IL-10 (rs1800872) were associated with increased risk of infection with influenza A/H3N2 virus (p < 0.05, OR = 2.04-2.58). In addition, IL-28 (rs8099917) genotypes GG (p < 0.05, OR = 0.49) and TG (p < 0.05, OR = 0.59) were associated with reduced risk of ILI symptom while genotype TT (p < 0.01, OR = 4.31) was associated with increased risk of ILI symptom. The results of this study demonstrated that polymorphisms of genes involved in the inflammatory and anti-inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus. Thorough insight on host immune response at the time of influenza A virus infection is required to ensure adequate patient care in the case of feature outbreaks. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] IL-10; IL-17; IL-1β; IL-28; Influenza A/H3N2 virus; Polymorphism
PMID: 27155288 [PubMed - as supplied by publisher]
[h=1]Seasonal influenza A/H3N2 virus infection and IL-1Β, IL-10, IL-17 and IL-28 polymorphisms in Iranian population.[/h] Rogo LD[SUP]1,[/SUP][SUP]2[/SUP], Rezaei F[SUP]1,[/SUP][SUP]3[/SUP], Marashi SM[SUP]1[/SUP], Yekaninejad MS[SUP]4[/SUP], Naseri M[SUP]1,[/SUP][SUP]3[/SUP], Ghavami N[SUP]1,[/SUP][SUP]3[/SUP], Mokhtari-Azad T[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Increased blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A/H3N2 virus infection. The study was aimed to investigate the polymorphisms of IL-1β, IL-10, IL-17 and IL-28 genes to find the possibility of their association with the clinical outcome of influenza A/H3N2 virus infection among the infected patients in Iran. This is a Case-Control study in which influenza A/H3N2 virus positive confirmed with real time PCR were the cases. DNA samples from groups were genotyped for polymorphisms in rs16944 (IL-1β), rs1800872 (IL-10), rs2275913 (IL-17) and rs8099917 (IL-28). Confidence interval (95% CI) and Odds ratio (OR) were calculated. IL-17 rs2275913 (GG and AG) were associated with risk of infection with that were statistically significant (p< 0.05, OR = 2.08-2.94). IL-1β (rs16944) (GG) was associated with reduced risk of infection (p < 0.01, OR = 0.46). Genotype GG and GT of IL-10 (rs1800872) were associated with increased risk of infection with influenza A/H3N2 virus (p < 0.05, OR = 2.04-2.58). In addition, IL-28 (rs8099917) genotypes GG (p < 0.05, OR = 0.49) and TG (p < 0.05, OR = 0.59) were associated with reduced risk of ILI symptom while genotype TT (p < 0.01, OR = 4.31) was associated with increased risk of ILI symptom. The results of this study demonstrated that polymorphisms of genes involved in the inflammatory and anti-inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus. Thorough insight on host immune response at the time of influenza A virus infection is required to ensure adequate patient care in the case of feature outbreaks. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] IL-10; IL-17; IL-1β; IL-28; Influenza A/H3N2 virus; Polymorphism
PMID: 27155288 [PubMed - as supplied by publisher]