tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2010 Aug 20. [Epub ahead of print]
Seasonal H1N1 2007 influenza virus infection is associated with elevated pre-exposure antibody titers to the 2009 pandemic influenza A (H1N1) virus.
Lemaitre M, Leruez-Ville M, De Lamballerie XN, Salez N, Garrone P, Fluckiger AC, Klatzmann D, Carrat F.
UPMC - Univ Paris 6, UMR-S 707, Paris, F-75012, France.
Abstract
ABSTRACT Background The new influenza strain detected in humans in April 2009 has caused the first influenza pandemic of the twenty-first century. A cross-reactive antibody response, in which antibodies against seasonal H1N1 viruses neutralized the 2009 pandemic influenza A (H1N1) virus (2009 pH1N1), was detected among individuals aged >60 years. However, factors other than age associated with such a cross-reactive antibody response are poorly documented. Objective Our objective was to examine factors potentially associated with elevated pre-exposure viro-neutralization and hemagglutination-inhibition antibody titers against the 2009 pH1N1. We also studied factors associated with antibody titers against the 2007 seasonal H1N1 virus. Methods One hundred subjects participating in an influenza cohort were selected. Sera collected in 2008 were analyzed using hemagglutination inhibition and viro-neutralization assays for the 2009 pH1N1 virus and the 2007 seasonal H1N1 virus. Viro-neutralization results were explored using a linear mixed-effect model and hemagglutination-inhibition results using linear-regression models for interval-censored data. Results Elevated antibody titers against 2009 pH1N1 were associated with seasonal 2007 H1N1 infection (viro-neutralization: P=0.006, hemagglutination-inhibition: P=0.018). Elevated antibody titers were also associated with age in the viro-neutralization assay (P<0.0001). Conclusion Seasonal 2007 H1N1 infection is an independent predictor of elevated pre-exposure antibody titers against 2009 pH1N1 and may have contributed to lowering the burden of the 2009 pH1N1 pandemic.
PMID: 20731679 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20731679
Seasonal H1N1 2007 influenza virus infection is associated with elevated pre-exposure antibody titers to the 2009 pandemic influenza A (H1N1) virus.
Lemaitre M, Leruez-Ville M, De Lamballerie XN, Salez N, Garrone P, Fluckiger AC, Klatzmann D, Carrat F.
UPMC - Univ Paris 6, UMR-S 707, Paris, F-75012, France.
Abstract
ABSTRACT Background The new influenza strain detected in humans in April 2009 has caused the first influenza pandemic of the twenty-first century. A cross-reactive antibody response, in which antibodies against seasonal H1N1 viruses neutralized the 2009 pandemic influenza A (H1N1) virus (2009 pH1N1), was detected among individuals aged >60 years. However, factors other than age associated with such a cross-reactive antibody response are poorly documented. Objective Our objective was to examine factors potentially associated with elevated pre-exposure viro-neutralization and hemagglutination-inhibition antibody titers against the 2009 pH1N1. We also studied factors associated with antibody titers against the 2007 seasonal H1N1 virus. Methods One hundred subjects participating in an influenza cohort were selected. Sera collected in 2008 were analyzed using hemagglutination inhibition and viro-neutralization assays for the 2009 pH1N1 virus and the 2007 seasonal H1N1 virus. Viro-neutralization results were explored using a linear mixed-effect model and hemagglutination-inhibition results using linear-regression models for interval-censored data. Results Elevated antibody titers against 2009 pH1N1 were associated with seasonal 2007 H1N1 infection (viro-neutralization: P=0.006, hemagglutination-inhibition: P=0.018). Elevated antibody titers were also associated with age in the viro-neutralization assay (P<0.0001). Conclusion Seasonal 2007 H1N1 infection is an independent predictor of elevated pre-exposure antibody titers against 2009 pH1N1 and may have contributed to lowering the burden of the 2009 pH1N1 pandemic.
PMID: 20731679 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20731679