tetano
Editor, Senior Moderator
Science
. 2022 Mar 11;375(6585):1122-1127.
doi: 10.1126/science.abm8108. Epub 2022 Mar 10.
The immunology and immunopathology of COVID-19
Miriam Merad[SUP] 1 [/SUP], Catherine A Blish[SUP] 2 [/SUP], Federica Sallusto[SUP] 3 4 [/SUP], Akiko Iwasaki[SUP] 5 6 [/SUP]
Affiliations
Abstract
Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.
. 2022 Mar 11;375(6585):1122-1127.
doi: 10.1126/science.abm8108. Epub 2022 Mar 10.
The immunology and immunopathology of COVID-19
Miriam Merad[SUP] 1 [/SUP], Catherine A Blish[SUP] 2 [/SUP], Federica Sallusto[SUP] 3 4 [/SUP], Akiko Iwasaki[SUP] 5 6 [/SUP]
Affiliations
- PMID: 35271343
- DOI: 10.1126/science.abm8108
Abstract
Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.