tetano
Editor, Senior Moderator
Science
. 2020 Aug 13;eaaz8432.
doi: 10.1126/science.aaz8432. Online ahead of print.
Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination
Carl W Davis[SUP] 1 2 [/SUP], Katherine J L Jackson[SUP] 3 [/SUP], Megan M McCausland[SUP] 1 2 [/SUP], Jaime Darce[SUP] 4 [/SUP], Cathy Chang[SUP] 1 2 [/SUP], Susanne L Linderman[SUP] 1 2 [/SUP], Chakravarthy Chennareddy[SUP] 1 2 [/SUP], Rebecca Gerkin[SUP] 2 5 [/SUP], Shantoria J Brown[SUP] 2 5 [/SUP], Jens Wrammert[SUP] 1 6 [/SUP], Aneesh K Mehta[SUP] 2 7 [/SUP], Wan Cheung Cheung[SUP] 4 [/SUP], Scott D Boyd[SUP] 3 [/SUP], Edmund K Waller[SUP] 2 5 [/SUP], Rafi Ahmed[SUP] 8 2 [/SUP]
Affiliations
Abstract
A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains, but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPC), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPC four weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their pre-vaccination levels after one year. This decline was driven by the loss of BMPC induced by the vaccine, while pre-existing BMPC were maintained. Our results suggest that most BMPC generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.
. 2020 Aug 13;eaaz8432.
doi: 10.1126/science.aaz8432. Online ahead of print.
Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination
Carl W Davis[SUP] 1 2 [/SUP], Katherine J L Jackson[SUP] 3 [/SUP], Megan M McCausland[SUP] 1 2 [/SUP], Jaime Darce[SUP] 4 [/SUP], Cathy Chang[SUP] 1 2 [/SUP], Susanne L Linderman[SUP] 1 2 [/SUP], Chakravarthy Chennareddy[SUP] 1 2 [/SUP], Rebecca Gerkin[SUP] 2 5 [/SUP], Shantoria J Brown[SUP] 2 5 [/SUP], Jens Wrammert[SUP] 1 6 [/SUP], Aneesh K Mehta[SUP] 2 7 [/SUP], Wan Cheung Cheung[SUP] 4 [/SUP], Scott D Boyd[SUP] 3 [/SUP], Edmund K Waller[SUP] 2 5 [/SUP], Rafi Ahmed[SUP] 8 2 [/SUP]
Affiliations
- PMID: 32792465
- DOI: 10.1126/science.aaz8432
Abstract
A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains, but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPC), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPC four weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their pre-vaccination levels after one year. This decline was driven by the loss of BMPC induced by the vaccine, while pre-existing BMPC were maintained. Our results suggest that most BMPC generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.