tetano
Editor, Senior Moderator
Science
. 2021 Jan 12;eabe6522.
doi: 10.1126/science.abe6522. Online ahead of print.
Immunological characteristics govern the transition of COVID-19 to endemicity
Jennie S Lavine[SUP] 1 [/SUP], Ottar N Bjornstad[SUP] 2 [/SUP], Rustom Antia[SUP] 3 [/SUP]
Affiliations
Abstract
We are currently faced with the question of how the CoV-2 severity may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly, but disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of CoV-2 and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase.
. 2021 Jan 12;eabe6522.
doi: 10.1126/science.abe6522. Online ahead of print.
Immunological characteristics govern the transition of COVID-19 to endemicity
Jennie S Lavine[SUP] 1 [/SUP], Ottar N Bjornstad[SUP] 2 [/SUP], Rustom Antia[SUP] 3 [/SUP]
Affiliations
- PMID: 33436525
- DOI: 10.1126/science.abe6522
Abstract
We are currently faced with the question of how the CoV-2 severity may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly, but disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of CoV-2 and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase.