Science: Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

[sharon sanders]

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

CATHERINE J. REYNOLDS https://orcid.org/0000-0002-1371-653XCORINNA PADE https://orcid.org/0000-0003-0626-2346JOSEPH M. GIBBONS https://orcid.org/0000-0002-7238-2381ASHLEY D. OTTER https://orcid.org/0000-0002-8317-9194KAI-MIN LIN https://orcid.org/0000-0003-2109-1530DIANA MUÑOZ SANDOVAL https://orcid.org/0000-0001-8350-3989FRANZISKA P. PIEPER https://orcid.org/0000-0002-4857-0518DAVID K. BUTLER https://orcid.org/0000-0003-1882-8159SIYI LIU https://orcid.org/0000-0003-0206-9661[...]ROSEMARY J. BOYTON https://orcid.org/0000-0002-5608-0797 +12 authors Authors Info & Affiliations

SCIENCE
14 Jun 2022
First Release
DOI: 10.1126/science.abq1841

• Abstract
• Results
• Discussion
• Materials and methods
• Acknowledgments
• Supplementary Materials
• References and Notes
• eLetters(0)

Abstract

The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.

https://www.science.org/doi/10.1126/science.abq1841

 

[gsgs]

I hate these abstracts-formulations. Things are being encomplicatified.

in HCWs with 3doses of mRNA vaccine (which is variant Wuhan-Hu-1) :

1.) mRNA vaccines work better against pre-omicron variants

2.) alpha infection gave less durable immunity against omicron
(than no infection at all)

3.) omicron infection alone gave better immunity against omicron
than Wuhan-HU1 plus omicron infections

---------------------------------------------
is it original antigenic sin ?

after 3 W-exposures (vaccine) , a new O-exposure increases
immunity against W but not O.

That would be bad for the new omicron-adapted vaccines

 

[Emily]

He, (Geert below), predicted the timing of the BA4-5 variants and how they'd be more transmissible and move deeper into lungs. But Topol said at least the hospital cases aren't up. Yet? I do hear the coughing again.

https://www.voiceforscienceandsolid...-to-who-please-dont-vaccinate-against-omicron
December 24, 2021
Second call to WHO: Please, don't vaccinate against Omicron.