tetano
Editor, Senior Moderator
Science
. 2020 Jun 8;eabb9263.
doi: 10.1126/science.abb9263. Online ahead of print.
Genomic Surveillance Reveals Multiple Introductions of SARS-CoV-2 Into Northern California
Xianding Deng[SUP] #[/SUP][SUP] 1 2 [/SUP], Wei Gu[SUP] #[/SUP][SUP] 1 2 [/SUP], Scot Federman[SUP] #[/SUP][SUP] 1 2 [/SUP], Louis du Plessis[SUP] #[/SUP][SUP] 3 [/SUP], Oliver G Pybus[SUP] 3 [/SUP], Nuno Faria[SUP] 3 [/SUP], Candace Wang[SUP] 1 2 [/SUP], Guixia Yu[SUP] 1 2 [/SUP], Brian Bushnell[SUP] 4 [/SUP], Chao-Yang Pan[SUP] 5 [/SUP], Hugo Guevara[SUP] 5 [/SUP], Alicia Sotomayor-Gonzalez[SUP] 1 2 [/SUP], Kelsey Zorn[SUP] 6 [/SUP], Allan Gopez[SUP] 1 [/SUP], Venice Servellita[SUP] 1 [/SUP], Elaine Hsu[SUP] 1 [/SUP], Steve Miller[SUP] 1 [/SUP], Trevor Bedford[SUP] 7 8 [/SUP], Alexander L Greninger[SUP] 7 9 [/SUP], Pavitra Roychoudhury[SUP] 7 9 [/SUP], Lea M Starita[SUP] 8 10 [/SUP], Michael Famulare[SUP] 11 [/SUP], Helen Y Chu[SUP] 8 12 [/SUP], Jay Shendure[SUP] 8 9 13 [/SUP], Keith R Jerome[SUP] 7 9 [/SUP], Catie Anderson[SUP] 14 [/SUP], Karthik Gangavarapu[SUP] 14 [/SUP], Mark Zeller[SUP] 14 [/SUP], Emily Spencer[SUP] 14 [/SUP], Kristian G Andersen[SUP] 14 [/SUP], Duncan MacCannell[SUP] 15 [/SUP], Clinton R Paden[SUP] 15 [/SUP], Yan Li[SUP] 15 [/SUP], Jing Zhang[SUP] 15 [/SUP], Suxiang Tong[SUP] 15 [/SUP], Gregory Armstrong[SUP] 15 [/SUP], Scott Morrow[SUP] 16 [/SUP], Matthew Willis[SUP] 17 [/SUP], Bela T Matyas[SUP] 18 [/SUP], Sundari Mase[SUP] 19 [/SUP], Olivia Kasirye[SUP] 20 [/SUP], Maggie Park[SUP] 21 [/SUP], Godfred Masinde[SUP] 22 [/SUP], Curtis Chan[SUP] 22 [/SUP], Alexander T Yu[SUP] 5 [/SUP], Shua J Chai[SUP] 5 15 [/SUP], Elsa Villarino[SUP] 23 [/SUP], Brandon Bonin[SUP] 23 [/SUP], Debra A Wadford[SUP] 5 [/SUP], Charles Y Chiu[SUP] 24 2 25 [/SUP]
Affiliations
Abstract
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning 9 counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least 7 different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington State, with lack of a predominant lineage and limited transmission between communities. Lineages associated with outbreak clusters in 2 counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain SARS-CoV-2 spread in California and other states.
. 2020 Jun 8;eabb9263.
doi: 10.1126/science.abb9263. Online ahead of print.
Genomic Surveillance Reveals Multiple Introductions of SARS-CoV-2 Into Northern California
Xianding Deng[SUP] #[/SUP][SUP] 1 2 [/SUP], Wei Gu[SUP] #[/SUP][SUP] 1 2 [/SUP], Scot Federman[SUP] #[/SUP][SUP] 1 2 [/SUP], Louis du Plessis[SUP] #[/SUP][SUP] 3 [/SUP], Oliver G Pybus[SUP] 3 [/SUP], Nuno Faria[SUP] 3 [/SUP], Candace Wang[SUP] 1 2 [/SUP], Guixia Yu[SUP] 1 2 [/SUP], Brian Bushnell[SUP] 4 [/SUP], Chao-Yang Pan[SUP] 5 [/SUP], Hugo Guevara[SUP] 5 [/SUP], Alicia Sotomayor-Gonzalez[SUP] 1 2 [/SUP], Kelsey Zorn[SUP] 6 [/SUP], Allan Gopez[SUP] 1 [/SUP], Venice Servellita[SUP] 1 [/SUP], Elaine Hsu[SUP] 1 [/SUP], Steve Miller[SUP] 1 [/SUP], Trevor Bedford[SUP] 7 8 [/SUP], Alexander L Greninger[SUP] 7 9 [/SUP], Pavitra Roychoudhury[SUP] 7 9 [/SUP], Lea M Starita[SUP] 8 10 [/SUP], Michael Famulare[SUP] 11 [/SUP], Helen Y Chu[SUP] 8 12 [/SUP], Jay Shendure[SUP] 8 9 13 [/SUP], Keith R Jerome[SUP] 7 9 [/SUP], Catie Anderson[SUP] 14 [/SUP], Karthik Gangavarapu[SUP] 14 [/SUP], Mark Zeller[SUP] 14 [/SUP], Emily Spencer[SUP] 14 [/SUP], Kristian G Andersen[SUP] 14 [/SUP], Duncan MacCannell[SUP] 15 [/SUP], Clinton R Paden[SUP] 15 [/SUP], Yan Li[SUP] 15 [/SUP], Jing Zhang[SUP] 15 [/SUP], Suxiang Tong[SUP] 15 [/SUP], Gregory Armstrong[SUP] 15 [/SUP], Scott Morrow[SUP] 16 [/SUP], Matthew Willis[SUP] 17 [/SUP], Bela T Matyas[SUP] 18 [/SUP], Sundari Mase[SUP] 19 [/SUP], Olivia Kasirye[SUP] 20 [/SUP], Maggie Park[SUP] 21 [/SUP], Godfred Masinde[SUP] 22 [/SUP], Curtis Chan[SUP] 22 [/SUP], Alexander T Yu[SUP] 5 [/SUP], Shua J Chai[SUP] 5 15 [/SUP], Elsa Villarino[SUP] 23 [/SUP], Brandon Bonin[SUP] 23 [/SUP], Debra A Wadford[SUP] 5 [/SUP], Charles Y Chiu[SUP] 24 2 25 [/SUP]
Affiliations
- PMID: 32513865
- DOI: 10.1126/science.abb9263
Abstract
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning 9 counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least 7 different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington State, with lack of a predominant lineage and limited transmission between communities. Lineages associated with outbreak clusters in 2 counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain SARS-CoV-2 spread in California and other states.