tetano
Editor, Senior Moderator
Science
. 2021 Aug 31;eabh1823.
doi: 10.1126/science.abh1823. Online ahead of print.
Cross-reactive CD4 [SUP]+[/SUP] T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Lucie Loyal[SUP] 1 2 3 4 5 [/SUP], Julian Braun[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Larissa Henze[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Beate Kruse[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Manuela Dingeldey[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Ulf Reimer[SUP] #[/SUP][SUP] 4 2 [/SUP], Florian Kern[SUP] #[/SUP][SUP] 4 5 2 3 [/SUP], Tatjana Schwarz[SUP] #[/SUP][SUP] 2 3 6 7 [/SUP], Maike Mangold[SUP] 1 3 4 5 [/SUP], Clara Unger[SUP] 1 3 4 5 [/SUP], Friederike Dörfler[SUP] 1 4 [/SUP], Shirin Kadler[SUP] 1 7 4 8 [/SUP], Jennifer Rosowski[SUP] 1 7 4 8 [/SUP], Kübrah Gürcan[SUP] 1 7 4 8 [/SUP], Zehra Uyar-Aydin[SUP] 1 7 4 8 [/SUP], Marco Frentsch[SUP] 3 9 10 [/SUP], Florian Kurth[SUP] 3 8 11 12 [/SUP], Karsten Schnatbaum[SUP] 4 2 [/SUP], Maren Eckey[SUP] 4 2 [/SUP], Stefan Hippenstiel[SUP] 3 11 [/SUP], Andreas Hocke[SUP] 3 11 [/SUP], Marcel A Müller[SUP] 3 5 7 13 [/SUP], Birgit Sawitzki[SUP] 3 14 [/SUP], Stefan Miltenyi[SUP] 9 6 [/SUP], Friedemann Paul[SUP] 10 11 1 15 [/SUP], Marcus A Mall[SUP] 12 16 17 [/SUP], Holger Wenschuh[SUP] 4 2 [/SUP], Sebastian Voigt[SUP] 13 18 19 [/SUP], Christian Drosten[SUP] 2 3 5 7 13 [/SUP], Roland Lauster[SUP] 1 7 4 8 [/SUP], Nils Lachman[SUP] 3 20 [/SUP], Leif-Erik Sander[SUP] 3 11 11 [/SUP], Victor M Corman[SUP] 2 3 5 7 13 [/SUP], Jobst Röhmel[SUP] 12 16 [/SUP], Lil Meyer-Arndt[SUP] 1 3 10 4 5 1 15 21 [/SUP], Andreas Thiel[SUP] 22 3 4 5 [/SUP], Claudia Giesecke-Thiel[SUP] 23 24 [/SUP]
Affiliations
Abstract
The functional relevance of pre-existing cross-immunity to SARS-CoV-2 is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4[SUP]+[/SUP] T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that pre-existing spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 mRNA vaccination displaying kinetics similar to secondary immune responses. Our results highlight the functional contribution of pre-existing spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity following primary SARS-CoV-2 immunization and the high rate of asymptomatic/mild COVID-19 disease courses.
. 2021 Aug 31;eabh1823.
doi: 10.1126/science.abh1823. Online ahead of print.
Cross-reactive CD4 [SUP]+[/SUP] T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Lucie Loyal[SUP] 1 2 3 4 5 [/SUP], Julian Braun[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Larissa Henze[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Beate Kruse[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Manuela Dingeldey[SUP] #[/SUP][SUP] 1 3 4 5 [/SUP], Ulf Reimer[SUP] #[/SUP][SUP] 4 2 [/SUP], Florian Kern[SUP] #[/SUP][SUP] 4 5 2 3 [/SUP], Tatjana Schwarz[SUP] #[/SUP][SUP] 2 3 6 7 [/SUP], Maike Mangold[SUP] 1 3 4 5 [/SUP], Clara Unger[SUP] 1 3 4 5 [/SUP], Friederike Dörfler[SUP] 1 4 [/SUP], Shirin Kadler[SUP] 1 7 4 8 [/SUP], Jennifer Rosowski[SUP] 1 7 4 8 [/SUP], Kübrah Gürcan[SUP] 1 7 4 8 [/SUP], Zehra Uyar-Aydin[SUP] 1 7 4 8 [/SUP], Marco Frentsch[SUP] 3 9 10 [/SUP], Florian Kurth[SUP] 3 8 11 12 [/SUP], Karsten Schnatbaum[SUP] 4 2 [/SUP], Maren Eckey[SUP] 4 2 [/SUP], Stefan Hippenstiel[SUP] 3 11 [/SUP], Andreas Hocke[SUP] 3 11 [/SUP], Marcel A Müller[SUP] 3 5 7 13 [/SUP], Birgit Sawitzki[SUP] 3 14 [/SUP], Stefan Miltenyi[SUP] 9 6 [/SUP], Friedemann Paul[SUP] 10 11 1 15 [/SUP], Marcus A Mall[SUP] 12 16 17 [/SUP], Holger Wenschuh[SUP] 4 2 [/SUP], Sebastian Voigt[SUP] 13 18 19 [/SUP], Christian Drosten[SUP] 2 3 5 7 13 [/SUP], Roland Lauster[SUP] 1 7 4 8 [/SUP], Nils Lachman[SUP] 3 20 [/SUP], Leif-Erik Sander[SUP] 3 11 11 [/SUP], Victor M Corman[SUP] 2 3 5 7 13 [/SUP], Jobst Röhmel[SUP] 12 16 [/SUP], Lil Meyer-Arndt[SUP] 1 3 10 4 5 1 15 21 [/SUP], Andreas Thiel[SUP] 22 3 4 5 [/SUP], Claudia Giesecke-Thiel[SUP] 23 24 [/SUP]
Affiliations
- PMID: 34465633
- DOI: 10.1126/science.abh1823
Abstract
The functional relevance of pre-existing cross-immunity to SARS-CoV-2 is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4[SUP]+[/SUP] T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that pre-existing spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 mRNA vaccination displaying kinetics similar to secondary immune responses. Our results highlight the functional contribution of pre-existing spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity following primary SARS-CoV-2 immunization and the high rate of asymptomatic/mild COVID-19 disease courses.