tetano
Editor, Senior Moderator
Science. 2020 Apr 17. pii: eabb7314. doi: 10.1126/science.abb7314. [Epub ahead of print]
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Rockx B[SUP]1[/SUP], Kuiken T[SUP]2[/SUP], Herfst S[SUP]2[/SUP], Bestebroer T[SUP]2[/SUP], Lamers MM[SUP]2[/SUP], Oude Munnink BB[SUP]2[/SUP], de Meulder D[SUP]2[/SUP], van Amerongen G[SUP]3[/SUP], van den Brand J[SUP]2[/SUP], Okba NMA[SUP]2[/SUP], Schipper D[SUP]2[/SUP], van Run P[SUP]2[/SUP], Leijten L[SUP]2[/SUP], Sikkema R[SUP]2[/SUP], Verschoor E[SUP]4[/SUP], Verstrepen B[SUP]4[/SUP], Bogers W[SUP]4[/SUP], Langermans J[SUP]5,[/SUP][SUP]6[/SUP], Drosten C[SUP]7[/SUP], Fentener van Vlissingen M[SUP]8[/SUP], Fouchier R[SUP]2[/SUP], de Swart R[SUP]2[/SUP], Koopmans M[SUP]2[/SUP], Haagmans BL[SUP]1[/SUP].
Author information
Abstract
The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.
Copyright ? 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PMID:32303590DOI:10.1126/science.abb7314
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Rockx B[SUP]1[/SUP], Kuiken T[SUP]2[/SUP], Herfst S[SUP]2[/SUP], Bestebroer T[SUP]2[/SUP], Lamers MM[SUP]2[/SUP], Oude Munnink BB[SUP]2[/SUP], de Meulder D[SUP]2[/SUP], van Amerongen G[SUP]3[/SUP], van den Brand J[SUP]2[/SUP], Okba NMA[SUP]2[/SUP], Schipper D[SUP]2[/SUP], van Run P[SUP]2[/SUP], Leijten L[SUP]2[/SUP], Sikkema R[SUP]2[/SUP], Verschoor E[SUP]4[/SUP], Verstrepen B[SUP]4[/SUP], Bogers W[SUP]4[/SUP], Langermans J[SUP]5,[/SUP][SUP]6[/SUP], Drosten C[SUP]7[/SUP], Fentener van Vlissingen M[SUP]8[/SUP], Fouchier R[SUP]2[/SUP], de Swart R[SUP]2[/SUP], Koopmans M[SUP]2[/SUP], Haagmans BL[SUP]1[/SUP].
Author information
Abstract
The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.
Copyright ? 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PMID:32303590DOI:10.1126/science.abb7314