Mary Wilson
Well-known member
7 Jun 2022
DOI: 10.1126/scitranslmed.abq3059
JUSTIN J. FRERE, RANDAL A. SERAFINI, KERRI D. PRYCE, MARIANNA ZAZHYTS, KAKOHEI OISHI, ILONA GOLYNKER, MARYLINE PANIS, JEFFREY ZIMERING, SHU HORIUCHI, [...]BENJAMIN R. TENOEVER
Abstract
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely impacted the olfactory bulb (OB) and epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month post viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics.
https://www.science.org/doi/10.1126/scitranslmed.abq3059
DOI: 10.1126/scitranslmed.abq3059
JUSTIN J. FRERE, RANDAL A. SERAFINI, KERRI D. PRYCE, MARIANNA ZAZHYTS, KAKOHEI OISHI, ILONA GOLYNKER, MARYLINE PANIS, JEFFREY ZIMERING, SHU HORIUCHI, [...]BENJAMIN R. TENOEVER
Abstract
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely impacted the olfactory bulb (OB) and epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month post viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics.
https://www.science.org/doi/10.1126/scitranslmed.abq3059
