tetano
Editor, Senior Moderator
Sci Total Environ. 2020 Apr 22;728:138812. doi: 10.1016/j.scitotenv.2020.138812. [Epub ahead of print]
Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19.
Hu X[SUP]1[/SUP], Xing Y[SUP]2[/SUP], Jia J[SUP]1[/SUP], Ni W[SUP]3[/SUP], Liang J[SUP]1[/SUP], Zhao D[SUP]1[/SUP], Song X[SUP]1[/SUP], Gao R[SUP]4[/SUP], Jiang F[SUP]5[/SUP].
Author information
Abstract
Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients with re-detectable viral RNA after showing negative on RT-PCR test (intermittent negative status) were also analyzed. A total of 59 patients confirmed with COVID-19 were included in this study, with a median duration of 1 (interquartile range, IQR: 0-2) day from symptom onset to hospital admission. Median communicable period (from first day of positive nucleic acid test to first day of consecutive negative results) was 14 (IQR: 10-18) days, and 7 (IQR: 6-10) days for 10 patients with intermittent negative results. Age older than 45 years (hazard ratio, HR: 0.378; 95% confidence interval, CI: 0.205-0.698) and chest tightness (HR: 0.290; 95%CI: 0.091-0.919) were factors indecently affecting negative conversion of SARS-CoV-2 RNA. Headache (odds ratio: 7.553; 95%CI: 1.011-28.253) was significantly associated with intermittent negative status, with a predicted probability of 60%. Older age and chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA in hospitalized patients. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
Coronavirus disease 2019 (COVID-19); Hazard ratio; Negative conversion; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
PMID:32335406DOI:10.1016/j.scitotenv.2020.138812
Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19.
Hu X[SUP]1[/SUP], Xing Y[SUP]2[/SUP], Jia J[SUP]1[/SUP], Ni W[SUP]3[/SUP], Liang J[SUP]1[/SUP], Zhao D[SUP]1[/SUP], Song X[SUP]1[/SUP], Gao R[SUP]4[/SUP], Jiang F[SUP]5[/SUP].
Author information
Abstract
Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients with re-detectable viral RNA after showing negative on RT-PCR test (intermittent negative status) were also analyzed. A total of 59 patients confirmed with COVID-19 were included in this study, with a median duration of 1 (interquartile range, IQR: 0-2) day from symptom onset to hospital admission. Median communicable period (from first day of positive nucleic acid test to first day of consecutive negative results) was 14 (IQR: 10-18) days, and 7 (IQR: 6-10) days for 10 patients with intermittent negative results. Age older than 45 years (hazard ratio, HR: 0.378; 95% confidence interval, CI: 0.205-0.698) and chest tightness (HR: 0.290; 95%CI: 0.091-0.919) were factors indecently affecting negative conversion of SARS-CoV-2 RNA. Headache (odds ratio: 7.553; 95%CI: 1.011-28.253) was significantly associated with intermittent negative status, with a predicted probability of 60%. Older age and chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA in hospitalized patients. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
Coronavirus disease 2019 (COVID-19); Hazard ratio; Negative conversion; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
PMID:32335406DOI:10.1016/j.scitotenv.2020.138812