tetano
Editor, Senior Moderator
Sci Rep
. 2024 Sep 18;14(1):21815.
doi: 10.1038/s41598-024-71791-8. The comparison of pathogenicity among SARS-CoV-2 variants in domestic cats
Eun-Sil Park[SUP] #[/SUP][SUP] 1 [/SUP], Yudai Kuroda[SUP] #[/SUP][SUP] 1 [/SUP], Akihiko Uda[SUP] 1 [/SUP], Yoshihiro Kaku[SUP] 1 [/SUP], Akiko Okutani[SUP] 1 [/SUP], Akitoyo Hotta[SUP] 1 2 [/SUP], Kango Tatemoto[SUP] 1 [/SUP], Keita Ishijima[SUP] 1 [/SUP], Yusuke Inoue[SUP] 1 [/SUP], Michiko Harada[SUP] 1 3 [/SUP], Yasushi Ami[SUP] 2 [/SUP], Masayuki Shirakura[SUP] 4 [/SUP], Shinji Watanabe[SUP] 4 [/SUP], Yasushi Suzuki[SUP] 4 [/SUP], Toshihiko Harada[SUP] 2 [/SUP], Akira Ainai[SUP] 5 [/SUP], Nozomi Shiwa[SUP] 5 [/SUP], Yusuke Sakai[SUP] 5 [/SUP], Naoko Iwata-Yoshikawa[SUP] 5 [/SUP], Noriyo Nagata[SUP] 5 [/SUP], Tadaki Suzuki[SUP] 5 [/SUP], Hideki Hasegawa[SUP] 4 [/SUP], Ken Maeda[SUP] 6 7 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected or isolated from domestic cats. It is unclear whether cats play an important role in the SARS-CoV-2 transmission cycle. In this study, we examined the susceptibility of cats to SARS-CoV-2, including wild type and variants, by animal experiments. Cats inoculated with wild type, gamma, and delta variants secreted a large amount of SARS-CoV-2 for 1 week after the inoculation from nasal, oropharyngeal, and rectal routes. Only 100 TCID[SUB]50[/SUB] of virus could infect cats and replicate well without severe clinical symptoms. In addition, one cat inoculated with wild type showed persistent virus secretion in feces for over 28 days post-inoculation (dpi). The titer of virus-neutralizing (VN) antibodies against SARS-CoV-2 increased from 11 dpi, reaching a peak at 14 dpi. However, the omicron variant could not replicate well in cat tissues and induced a lower titer of VN antibodies. It is concluded that cats were highly susceptible to SARS-CoV-2 infection, but not to the Omicron Variant, which caused the attenuated pathogenicity.
. 2024 Sep 18;14(1):21815.
doi: 10.1038/s41598-024-71791-8. The comparison of pathogenicity among SARS-CoV-2 variants in domestic cats
Eun-Sil Park[SUP] #[/SUP][SUP] 1 [/SUP], Yudai Kuroda[SUP] #[/SUP][SUP] 1 [/SUP], Akihiko Uda[SUP] 1 [/SUP], Yoshihiro Kaku[SUP] 1 [/SUP], Akiko Okutani[SUP] 1 [/SUP], Akitoyo Hotta[SUP] 1 2 [/SUP], Kango Tatemoto[SUP] 1 [/SUP], Keita Ishijima[SUP] 1 [/SUP], Yusuke Inoue[SUP] 1 [/SUP], Michiko Harada[SUP] 1 3 [/SUP], Yasushi Ami[SUP] 2 [/SUP], Masayuki Shirakura[SUP] 4 [/SUP], Shinji Watanabe[SUP] 4 [/SUP], Yasushi Suzuki[SUP] 4 [/SUP], Toshihiko Harada[SUP] 2 [/SUP], Akira Ainai[SUP] 5 [/SUP], Nozomi Shiwa[SUP] 5 [/SUP], Yusuke Sakai[SUP] 5 [/SUP], Naoko Iwata-Yoshikawa[SUP] 5 [/SUP], Noriyo Nagata[SUP] 5 [/SUP], Tadaki Suzuki[SUP] 5 [/SUP], Hideki Hasegawa[SUP] 4 [/SUP], Ken Maeda[SUP] 6 7 [/SUP]
Affiliations
- PMID: 39294189
- DOI: 10.1038/s41598-024-71791-8
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected or isolated from domestic cats. It is unclear whether cats play an important role in the SARS-CoV-2 transmission cycle. In this study, we examined the susceptibility of cats to SARS-CoV-2, including wild type and variants, by animal experiments. Cats inoculated with wild type, gamma, and delta variants secreted a large amount of SARS-CoV-2 for 1 week after the inoculation from nasal, oropharyngeal, and rectal routes. Only 100 TCID[SUB]50[/SUB] of virus could infect cats and replicate well without severe clinical symptoms. In addition, one cat inoculated with wild type showed persistent virus secretion in feces for over 28 days post-inoculation (dpi). The titer of virus-neutralizing (VN) antibodies against SARS-CoV-2 increased from 11 dpi, reaching a peak at 14 dpi. However, the omicron variant could not replicate well in cat tissues and induced a lower titer of VN antibodies. It is concluded that cats were highly susceptible to SARS-CoV-2 infection, but not to the Omicron Variant, which caused the attenuated pathogenicity.