tetano
Editor, Senior Moderator
Sci Rep
. 2022 Sep 1;12(1):14906.
doi: 10.1038/s41598-022-18991-2.
SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units
Jan Benes[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Miłosz Jankowski[SUP] #[/SUP][SUP] 4 5 [/SUP], Konstanty Szułdrzynski[SUP] 4 5 [/SUP], Roman Zahorec[SUP] 6 [/SUP], Mitja Lainscak[SUP] 7 8 [/SUP], Zoltán Ruszkai[SUP] 9 [/SUP], Matej Podbregar[SUP] 8 10 [/SUP], Jan Zatloukal[SUP] 1 2 [/SUP], Jakub Kletecka[SUP] 1 2 [/SUP], Krzysztof Kusza[SUP] 11 [/SUP], Jakub Szrama[SUP] 11 [/SUP], Estera Ramic[SUP] 12 [/SUP], Katarina Galkova[SUP] 13 [/SUP], Stefan Krbila[SUP] 14 [/SUP], Josef Valky[SUP] 15 [/SUP], Jaka Ivanic[SUP] 16 [/SUP], Marko Kurnik[SUP] 10 [/SUP], Angéla Mikó[SUP] 9 [/SUP], Tamás Kiss[SUP] 17 [/SUP], Barbara Hetényi[SUP] 17 [/SUP], Peter Hegyi[SUP] 18 19 20 [/SUP], Alan Sustic[SUP] 21 22 [/SUP], Zsolt Molnar[SUP] 23 24 25 [/SUP]
Affiliations
Abstract
The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative. We conducted a retrospective, international, multicentre study between March 2020 and February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Eleven centres from six countries provided data from 2139 patients. Patient characteristics were: median 68, [IQR 60-75] years of age; males: 67%; body mass index: 30.1 [27.0-34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p = 0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n = 54). The rest of the patients received non-invasive ventilation (n = 129), high flow nasal oxygen (n = 317), conventional oxygen therapy (n = 122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national-international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.
. 2022 Sep 1;12(1):14906.
doi: 10.1038/s41598-022-18991-2.
SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units
Jan Benes[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Miłosz Jankowski[SUP] #[/SUP][SUP] 4 5 [/SUP], Konstanty Szułdrzynski[SUP] 4 5 [/SUP], Roman Zahorec[SUP] 6 [/SUP], Mitja Lainscak[SUP] 7 8 [/SUP], Zoltán Ruszkai[SUP] 9 [/SUP], Matej Podbregar[SUP] 8 10 [/SUP], Jan Zatloukal[SUP] 1 2 [/SUP], Jakub Kletecka[SUP] 1 2 [/SUP], Krzysztof Kusza[SUP] 11 [/SUP], Jakub Szrama[SUP] 11 [/SUP], Estera Ramic[SUP] 12 [/SUP], Katarina Galkova[SUP] 13 [/SUP], Stefan Krbila[SUP] 14 [/SUP], Josef Valky[SUP] 15 [/SUP], Jaka Ivanic[SUP] 16 [/SUP], Marko Kurnik[SUP] 10 [/SUP], Angéla Mikó[SUP] 9 [/SUP], Tamás Kiss[SUP] 17 [/SUP], Barbara Hetényi[SUP] 17 [/SUP], Peter Hegyi[SUP] 18 19 20 [/SUP], Alan Sustic[SUP] 21 22 [/SUP], Zsolt Molnar[SUP] 23 24 25 [/SUP]
Affiliations
- PMID: 36050403
- DOI: 10.1038/s41598-022-18991-2
Abstract
The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative. We conducted a retrospective, international, multicentre study between March 2020 and February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Eleven centres from six countries provided data from 2139 patients. Patient characteristics were: median 68, [IQR 60-75] years of age; males: 67%; body mass index: 30.1 [27.0-34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p = 0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n = 54). The rest of the patients received non-invasive ventilation (n = 129), high flow nasal oxygen (n = 317), conventional oxygen therapy (n = 122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national-international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.