tetano
Editor, Senior Moderator
Sci Rep
. 2025 Jan 7;15(1):1050.
doi: 10.1038/s41598-025-85360-0. Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia
Ekaterina Krieger[SUP] 1 2 [/SUP], Alexander V Kudryavtsev[SUP] 3 [/SUP], Ekaterina Sharashova[SUP] 4 [/SUP], Olga Samodova[SUP] 5 [/SUP], Vitaly A Postoev[SUP] 6 [/SUP]
Affiliations
We investigated and compared mortality rates and risk factors for pre-pandemic and pandemic all-cause mortality in a population-based cohort of men and women in Arkhangelsk, Russia. A prospective cohort study enrolled 2,324 participants aged 35 to 69 years between 2015 and 2017. All participants were followed up for all-cause deaths using the mortality registry. Mortality rates per 1000 person-years were calculated for men and women in the pre-pandemic and pandemic periods. Cox regression models were used to investigate demographic, lifestyle, and health characteristics associated with increased risk of death in both periods. During the pandemic, age-standardized all-cause mortality increased in women, but minor change was observed in men. Older age, smoking, and diabetes were associated with a higher risk of all-cause death in both periods and for both sexes. In women, higher risk during the pandemic was associated with obesity, angina, elevated cystatin C levels, and a history of COVID-19. In men, asthma and elevated hs-Troponin T levels increased the risk of death during the pandemic, while elevated hs-CRP and NT-proBNP levels were associated with higher risk in both periods. Targeted preventive interventions for men and women with specific risk factors can be implemented during potential future infectious disease outbreaks.
Keywords: All-cause mortality; COVID-19; Risk factors; Russia; SARS-CoV-2.
. 2025 Jan 7;15(1):1050.
doi: 10.1038/s41598-025-85360-0. Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia
Ekaterina Krieger[SUP] 1 2 [/SUP], Alexander V Kudryavtsev[SUP] 3 [/SUP], Ekaterina Sharashova[SUP] 4 [/SUP], Olga Samodova[SUP] 5 [/SUP], Vitaly A Postoev[SUP] 6 [/SUP]
Affiliations
- PMID: 39774287
- PMCID: PMC11706959
- DOI: 10.1038/s41598-025-85360-0
We investigated and compared mortality rates and risk factors for pre-pandemic and pandemic all-cause mortality in a population-based cohort of men and women in Arkhangelsk, Russia. A prospective cohort study enrolled 2,324 participants aged 35 to 69 years between 2015 and 2017. All participants were followed up for all-cause deaths using the mortality registry. Mortality rates per 1000 person-years were calculated for men and women in the pre-pandemic and pandemic periods. Cox regression models were used to investigate demographic, lifestyle, and health characteristics associated with increased risk of death in both periods. During the pandemic, age-standardized all-cause mortality increased in women, but minor change was observed in men. Older age, smoking, and diabetes were associated with a higher risk of all-cause death in both periods and for both sexes. In women, higher risk during the pandemic was associated with obesity, angina, elevated cystatin C levels, and a history of COVID-19. In men, asthma and elevated hs-Troponin T levels increased the risk of death during the pandemic, while elevated hs-CRP and NT-proBNP levels were associated with higher risk in both periods. Targeted preventive interventions for men and women with specific risk factors can be implemented during potential future infectious disease outbreaks.
Keywords: All-cause mortality; COVID-19; Risk factors; Russia; SARS-CoV-2.