tetano
Editor, Senior Moderator
Sci Rep
. 2022 May 13;12(1):7977.
doi: 10.1038/s41598-022-11929-8.
Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19
Kapil Nanwani-Nanwani[SUP] 1 [/SUP], Lorenzo López-Pérez[SUP] 2 [/SUP], Carola Giménez-Esparza[SUP] 3 [/SUP], Inés Ruiz-Barranco[SUP] 1 [/SUP], Elena Carrillo[SUP] 1 [/SUP], María Soledad Arellano[SUP] 1 [/SUP], Domingo Díaz-Díaz[SUP] 2 [/SUP], Beatriz Hurtado[SUP] 3 [/SUP], Andoni García-Muñoz[SUP] 1 [/SUP], María Ángeles Relucio[SUP] 3 [/SUP], Manuel Quintana-Díaz[SUP] 1 4 5 [/SUP], María Rosario Úrbez[SUP] 6 [/SUP], Andrés Saravia[SUP] 1 [/SUP], María Victoria Bonan[SUP] 7 [/SUP], Francisco García-Río[SUP] 4 8 9 [/SUP], María Luisa Testillano[SUP] 10 [/SUP], Jesús Villar[SUP] 9 11 12 [/SUP], Abelardo García de Lorenzo[SUP] 1 4 5 [/SUP], José Manuel Añón[SUP] 13 14 15 [/SUP]
Affiliations
Abstract
Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The aim of this study was to determine the prevalence of post-intensive care syndrome (PICS) at 3 months after hospital discharge, in a cohort of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ambispective, observational study was conducted in three hospitals with intensive care unit (ICU) follow-up clinics. We studied adults who survived a critical illness due to SARS-CoV-2 infection requiring invasive mechanical ventilation. A physical (muscle strength and pulmonary function), functional [12-Item Short Form Health Survey (SF-12), and Barthel score], psychological [hospital anxiety and depression (HADS) and posttraumatic stress disorder symptom severity scales], and cognitive [Montreal cognitive assessment (MoCA) test] assessment were performed. A total of 186 patients were evaluated at 88 days (IQR 68-121) after hospital discharge. Mean age was 59 ± 12 years old, 126 (68%) patients were men, and median length of mechanical ventilation was 14 days (IQR 8-31). About 3 out of 4 patients (n = 139, 75%) met PICS criteria. Symptoms of cognitive and psychiatric disorders were found in 59 (32%) and 58 (31%) patients, respectively. Ninety-one (49%) patients had muscle weakness. Pulmonary function tests in patients with no respiratory comorbidities showed a normal pattern in 93 (50%) patients, and a restrictive disorder in 62 (33%) patients. Also, 69 patients (37%) were on sick leave, while 32 (17%) had resumed work at the time of assessment. In conclusion, survivors of critical illness due to SARS-CoV-2 infection requiring mechanical ventilation have a high prevalence of PICS. Physical domain is the most frequently damaged, followed by cognitive and psychiatric disorders. ICU follow-up clinics enable the assistance of this vulnerable population.
. 2022 May 13;12(1):7977.
doi: 10.1038/s41598-022-11929-8.
Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19
Kapil Nanwani-Nanwani[SUP] 1 [/SUP], Lorenzo López-Pérez[SUP] 2 [/SUP], Carola Giménez-Esparza[SUP] 3 [/SUP], Inés Ruiz-Barranco[SUP] 1 [/SUP], Elena Carrillo[SUP] 1 [/SUP], María Soledad Arellano[SUP] 1 [/SUP], Domingo Díaz-Díaz[SUP] 2 [/SUP], Beatriz Hurtado[SUP] 3 [/SUP], Andoni García-Muñoz[SUP] 1 [/SUP], María Ángeles Relucio[SUP] 3 [/SUP], Manuel Quintana-Díaz[SUP] 1 4 5 [/SUP], María Rosario Úrbez[SUP] 6 [/SUP], Andrés Saravia[SUP] 1 [/SUP], María Victoria Bonan[SUP] 7 [/SUP], Francisco García-Río[SUP] 4 8 9 [/SUP], María Luisa Testillano[SUP] 10 [/SUP], Jesús Villar[SUP] 9 11 12 [/SUP], Abelardo García de Lorenzo[SUP] 1 4 5 [/SUP], José Manuel Añón[SUP] 13 14 15 [/SUP]
Affiliations
- PMID: 35562379
- DOI: 10.1038/s41598-022-11929-8
Abstract
Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The aim of this study was to determine the prevalence of post-intensive care syndrome (PICS) at 3 months after hospital discharge, in a cohort of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ambispective, observational study was conducted in three hospitals with intensive care unit (ICU) follow-up clinics. We studied adults who survived a critical illness due to SARS-CoV-2 infection requiring invasive mechanical ventilation. A physical (muscle strength and pulmonary function), functional [12-Item Short Form Health Survey (SF-12), and Barthel score], psychological [hospital anxiety and depression (HADS) and posttraumatic stress disorder symptom severity scales], and cognitive [Montreal cognitive assessment (MoCA) test] assessment were performed. A total of 186 patients were evaluated at 88 days (IQR 68-121) after hospital discharge. Mean age was 59 ± 12 years old, 126 (68%) patients were men, and median length of mechanical ventilation was 14 days (IQR 8-31). About 3 out of 4 patients (n = 139, 75%) met PICS criteria. Symptoms of cognitive and psychiatric disorders were found in 59 (32%) and 58 (31%) patients, respectively. Ninety-one (49%) patients had muscle weakness. Pulmonary function tests in patients with no respiratory comorbidities showed a normal pattern in 93 (50%) patients, and a restrictive disorder in 62 (33%) patients. Also, 69 patients (37%) were on sick leave, while 32 (17%) had resumed work at the time of assessment. In conclusion, survivors of critical illness due to SARS-CoV-2 infection requiring mechanical ventilation have a high prevalence of PICS. Physical domain is the most frequently damaged, followed by cognitive and psychiatric disorders. ICU follow-up clinics enable the assistance of this vulnerable population.