tetano
Editor, Senior Moderator
Sci Rep
. 2021 Jul 6;11(1):13898.
doi: 10.1038/s41598-021-92357-y.
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
Manon Vouga[SUP] #[/SUP][SUP] 1 [/SUP], Guillaume Favre[SUP] #[/SUP][SUP] 1 [/SUP], Oscar Martinez-Perez[SUP] #[/SUP][SUP] 2 [/SUP], Leo Pomar[SUP] #[/SUP][SUP] 1 [/SUP], Laura Forcen Acebal[SUP] 3 [/SUP], Alejandra Abascal-Saiz[SUP] 4 [/SUP], Maria Rosa Vila Hernandez[SUP] 5 [/SUP], Najeh Hcini[SUP] 6 [/SUP], Véronique Lambert[SUP] 6 [/SUP], Gabriel Carles[SUP] 6 [/SUP], Joanna Sichitiu[SUP] 1 7 [/SUP], Laurent Salomon[SUP] 7 [/SUP], Julien Stirnemann[SUP] 7 [/SUP], Yves Ville[SUP] 7 [/SUP], Begoña Martinez de Tejada[SUP] 8 [/SUP], Anna Goncé[SUP] 9 [/SUP], Ameth Hawkins-Villarreal[SUP] 9 [/SUP], Karen Castillo[SUP] 9 [/SUP], Eduard Gratacos Solsona[SUP] 9 [/SUP], Lucas Trigo[SUP] 10 [/SUP], Brian Cleary[SUP] 11 [/SUP], Michael Geary[SUP] 12 [/SUP], Helena Bartels[SUP] 12 [/SUP], Feras Al-Kharouf[SUP] 12 [/SUP], Fergal Malone[SUP] 12 [/SUP], Mary Higgins[SUP] 13 [/SUP], Niamh Keating[SUP] 14 [/SUP], Susan Knowles[SUP] 15 [/SUP], Christophe Poncelet[SUP] 16 [/SUP], Carolina Carvalho Ribeiro-do-Valle[SUP] 17 [/SUP], Fernanda Surita[SUP] 17 [/SUP], Amanda Dantas-Silva[SUP] 17 [/SUP], Carolina Borrelli[SUP] 17 [/SUP], Adriana Gomes Luz[SUP] 17 [/SUP], Javiera Fuenzalida[SUP] 18 [/SUP], Jorge Carvajal[SUP] 18 [/SUP], Manuel Guerra Canales[SUP] 19 [/SUP], Olivia Hernandez[SUP] 20 [/SUP], Olga Grechukhina[SUP] 21 [/SUP], Albert I Ko[SUP] 22 [/SUP], Uma Reddy[SUP] 22 [/SUP], Rita Figueiredo[SUP] 23 [/SUP], Marina Moucho[SUP] 23 [/SUP], Pedro Viana Pinto[SUP] 23 [/SUP], Carmen De Luca[SUP] 24 [/SUP], Marco De Santis[SUP] 24 [/SUP], Diogo Ayres de Campos[SUP] 25 [/SUP], Inês Martins[SUP] 25 [/SUP], Charles Garabedian[SUP] 26 [/SUP], Damien Subtil[SUP] 26 [/SUP], Betania Bohrer[SUP] 27 [/SUP], Maria Lucia Da Rocha Oppermann[SUP] 28 [/SUP], Maria Celeste Osorio Wender[SUP] 28 [/SUP], Lavinia Schuler-Faccini[SUP] 29 [/SUP], Maria Teresa Vieira Sanseverino[SUP] 29 [/SUP], Camila Giugliani[SUP] 30 [/SUP], Luciana Friedrich[SUP] 27 [/SUP], Mariana Horn Scherer[SUP] 29 [/SUP], Nicolas Mottet[SUP] 31 [/SUP], Guillaume Ducarme[SUP] 32 [/SUP], Helene Pelerin[SUP] 33 [/SUP], Chloe Moreau[SUP] 33 [/SUP], Bénédicte Breton[SUP] 34 [/SUP], Thibaud Quibel[SUP] 35 [/SUP], Patrick Rozenberg[SUP] 35 [/SUP], Eric Giannoni[SUP] 1 [/SUP], Cristina Granado[SUP] 36 [/SUP], Cécile Monod[SUP] 36 [/SUP], Doris Mueller[SUP] 36 [/SUP], Irene Hoesli[SUP] 36 [/SUP], Dirk Bassler[SUP] 37 [/SUP], Sandra Heldstab[SUP] 38 [/SUP], Nicole Ochsenbein Kölble[SUP] 39 [/SUP], Loïc Sentilhes[SUP] 40 [/SUP], Melissa Charvet[SUP] 40 [/SUP], Jan Deprest[SUP] 41 [/SUP], Jute Richter[SUP] 41 [/SUP], Lennart Van der Veeken[SUP] 42 [/SUP], Béatrice Eggel-Hort[SUP] 43 [/SUP], Gaetan Plantefeve[SUP] 44 [/SUP], Mohamed Derouich[SUP] 45 [/SUP], Albaro José Nieto Calvache[SUP] 46 [/SUP], Maria Camila Lopez-Giron[SUP] 46 [/SUP], Juan Manuel Burgos-Luna[SUP] 46 [/SUP], Maria Fernanda Escobar-Vidarte[SUP] 46 [/SUP], Kurt Hecher[SUP] 47 [/SUP], Ann-Christin Tallarek[SUP] 47 [/SUP], Eran Hadar[SUP] 48 [/SUP], Karina Krajden Haratz[SUP] 49 [/SUP], Uri Amikam[SUP] 50 [/SUP], Gustavo Malinger[SUP] 50 [/SUP], Ron Maymon[SUP] 51 [/SUP], Yariv Yogev[SUP] 49 [/SUP], Leonhard Schäffer[SUP] 52 [/SUP], Arnaud Toussaint[SUP] 53 [/SUP], Marie-Claude Rossier[SUP] 54 [/SUP], Renato Augusto Moreira De Sa[SUP] 55 [/SUP], Claudia Grawe[SUP] 56 [/SUP], Karoline Aebi-Popp[SUP] 57 [/SUP], Anda-Petronela Radan[SUP] 58 [/SUP], Luigi Raio[SUP] 58 [/SUP], Daniel Surbek[SUP] 58 [/SUP], Paul Böckenhoff[SUP] 59 [/SUP], Brigitte Strizek[SUP] 59 [/SUP], Martin Kaufmann[SUP] 60 [/SUP], Andrea Bloch[SUP] 61 [/SUP], Michel Boulvain[SUP] 62 [/SUP], Silke Johann[SUP] 63 [/SUP], Sandra Andrea Heldstab[SUP] 64 [/SUP], Monya Todesco Bernasconi[SUP] 64 [/SUP], Gaston Grant[SUP] 65 [/SUP], Anis Feki[SUP] 65 [/SUP], Anne-Claude Muller Brochut[SUP] 66 [/SUP], Marylene Giral[SUP] 67 [/SUP], Lucie Sedille[SUP] 67 [/SUP], Andrea Papadia[SUP] 68 [/SUP], Romina Capoccia Brugger[SUP] 69 [/SUP], Brigitte Weber[SUP] 70 [/SUP], Tina Fischer[SUP] 71 [/SUP], Christian Kahlert[SUP] 72 [/SUP], Karin Nielsen Saines[SUP] 73 [/SUP], Mary Cambou[SUP] 74 [/SUP], Panagiotis Kanellos[SUP] 75 [/SUP], Xiang Chen[SUP] 76 [/SUP], Mingzhu Yin[SUP] 77 [/SUP], Annina Haessig[SUP] 78 [/SUP], Sandrine Ackermann[SUP] 1 [/SUP], David Baud[SUP] #[/SUP][SUP] 79 80 [/SUP], Alice Panchaud[SUP] #[/SUP][SUP] 81 82 [/SUP]
Affiliations
Abstract
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.
. 2021 Jul 6;11(1):13898.
doi: 10.1038/s41598-021-92357-y.
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
Manon Vouga[SUP] #[/SUP][SUP] 1 [/SUP], Guillaume Favre[SUP] #[/SUP][SUP] 1 [/SUP], Oscar Martinez-Perez[SUP] #[/SUP][SUP] 2 [/SUP], Leo Pomar[SUP] #[/SUP][SUP] 1 [/SUP], Laura Forcen Acebal[SUP] 3 [/SUP], Alejandra Abascal-Saiz[SUP] 4 [/SUP], Maria Rosa Vila Hernandez[SUP] 5 [/SUP], Najeh Hcini[SUP] 6 [/SUP], Véronique Lambert[SUP] 6 [/SUP], Gabriel Carles[SUP] 6 [/SUP], Joanna Sichitiu[SUP] 1 7 [/SUP], Laurent Salomon[SUP] 7 [/SUP], Julien Stirnemann[SUP] 7 [/SUP], Yves Ville[SUP] 7 [/SUP], Begoña Martinez de Tejada[SUP] 8 [/SUP], Anna Goncé[SUP] 9 [/SUP], Ameth Hawkins-Villarreal[SUP] 9 [/SUP], Karen Castillo[SUP] 9 [/SUP], Eduard Gratacos Solsona[SUP] 9 [/SUP], Lucas Trigo[SUP] 10 [/SUP], Brian Cleary[SUP] 11 [/SUP], Michael Geary[SUP] 12 [/SUP], Helena Bartels[SUP] 12 [/SUP], Feras Al-Kharouf[SUP] 12 [/SUP], Fergal Malone[SUP] 12 [/SUP], Mary Higgins[SUP] 13 [/SUP], Niamh Keating[SUP] 14 [/SUP], Susan Knowles[SUP] 15 [/SUP], Christophe Poncelet[SUP] 16 [/SUP], Carolina Carvalho Ribeiro-do-Valle[SUP] 17 [/SUP], Fernanda Surita[SUP] 17 [/SUP], Amanda Dantas-Silva[SUP] 17 [/SUP], Carolina Borrelli[SUP] 17 [/SUP], Adriana Gomes Luz[SUP] 17 [/SUP], Javiera Fuenzalida[SUP] 18 [/SUP], Jorge Carvajal[SUP] 18 [/SUP], Manuel Guerra Canales[SUP] 19 [/SUP], Olivia Hernandez[SUP] 20 [/SUP], Olga Grechukhina[SUP] 21 [/SUP], Albert I Ko[SUP] 22 [/SUP], Uma Reddy[SUP] 22 [/SUP], Rita Figueiredo[SUP] 23 [/SUP], Marina Moucho[SUP] 23 [/SUP], Pedro Viana Pinto[SUP] 23 [/SUP], Carmen De Luca[SUP] 24 [/SUP], Marco De Santis[SUP] 24 [/SUP], Diogo Ayres de Campos[SUP] 25 [/SUP], Inês Martins[SUP] 25 [/SUP], Charles Garabedian[SUP] 26 [/SUP], Damien Subtil[SUP] 26 [/SUP], Betania Bohrer[SUP] 27 [/SUP], Maria Lucia Da Rocha Oppermann[SUP] 28 [/SUP], Maria Celeste Osorio Wender[SUP] 28 [/SUP], Lavinia Schuler-Faccini[SUP] 29 [/SUP], Maria Teresa Vieira Sanseverino[SUP] 29 [/SUP], Camila Giugliani[SUP] 30 [/SUP], Luciana Friedrich[SUP] 27 [/SUP], Mariana Horn Scherer[SUP] 29 [/SUP], Nicolas Mottet[SUP] 31 [/SUP], Guillaume Ducarme[SUP] 32 [/SUP], Helene Pelerin[SUP] 33 [/SUP], Chloe Moreau[SUP] 33 [/SUP], Bénédicte Breton[SUP] 34 [/SUP], Thibaud Quibel[SUP] 35 [/SUP], Patrick Rozenberg[SUP] 35 [/SUP], Eric Giannoni[SUP] 1 [/SUP], Cristina Granado[SUP] 36 [/SUP], Cécile Monod[SUP] 36 [/SUP], Doris Mueller[SUP] 36 [/SUP], Irene Hoesli[SUP] 36 [/SUP], Dirk Bassler[SUP] 37 [/SUP], Sandra Heldstab[SUP] 38 [/SUP], Nicole Ochsenbein Kölble[SUP] 39 [/SUP], Loïc Sentilhes[SUP] 40 [/SUP], Melissa Charvet[SUP] 40 [/SUP], Jan Deprest[SUP] 41 [/SUP], Jute Richter[SUP] 41 [/SUP], Lennart Van der Veeken[SUP] 42 [/SUP], Béatrice Eggel-Hort[SUP] 43 [/SUP], Gaetan Plantefeve[SUP] 44 [/SUP], Mohamed Derouich[SUP] 45 [/SUP], Albaro José Nieto Calvache[SUP] 46 [/SUP], Maria Camila Lopez-Giron[SUP] 46 [/SUP], Juan Manuel Burgos-Luna[SUP] 46 [/SUP], Maria Fernanda Escobar-Vidarte[SUP] 46 [/SUP], Kurt Hecher[SUP] 47 [/SUP], Ann-Christin Tallarek[SUP] 47 [/SUP], Eran Hadar[SUP] 48 [/SUP], Karina Krajden Haratz[SUP] 49 [/SUP], Uri Amikam[SUP] 50 [/SUP], Gustavo Malinger[SUP] 50 [/SUP], Ron Maymon[SUP] 51 [/SUP], Yariv Yogev[SUP] 49 [/SUP], Leonhard Schäffer[SUP] 52 [/SUP], Arnaud Toussaint[SUP] 53 [/SUP], Marie-Claude Rossier[SUP] 54 [/SUP], Renato Augusto Moreira De Sa[SUP] 55 [/SUP], Claudia Grawe[SUP] 56 [/SUP], Karoline Aebi-Popp[SUP] 57 [/SUP], Anda-Petronela Radan[SUP] 58 [/SUP], Luigi Raio[SUP] 58 [/SUP], Daniel Surbek[SUP] 58 [/SUP], Paul Böckenhoff[SUP] 59 [/SUP], Brigitte Strizek[SUP] 59 [/SUP], Martin Kaufmann[SUP] 60 [/SUP], Andrea Bloch[SUP] 61 [/SUP], Michel Boulvain[SUP] 62 [/SUP], Silke Johann[SUP] 63 [/SUP], Sandra Andrea Heldstab[SUP] 64 [/SUP], Monya Todesco Bernasconi[SUP] 64 [/SUP], Gaston Grant[SUP] 65 [/SUP], Anis Feki[SUP] 65 [/SUP], Anne-Claude Muller Brochut[SUP] 66 [/SUP], Marylene Giral[SUP] 67 [/SUP], Lucie Sedille[SUP] 67 [/SUP], Andrea Papadia[SUP] 68 [/SUP], Romina Capoccia Brugger[SUP] 69 [/SUP], Brigitte Weber[SUP] 70 [/SUP], Tina Fischer[SUP] 71 [/SUP], Christian Kahlert[SUP] 72 [/SUP], Karin Nielsen Saines[SUP] 73 [/SUP], Mary Cambou[SUP] 74 [/SUP], Panagiotis Kanellos[SUP] 75 [/SUP], Xiang Chen[SUP] 76 [/SUP], Mingzhu Yin[SUP] 77 [/SUP], Annina Haessig[SUP] 78 [/SUP], Sandrine Ackermann[SUP] 1 [/SUP], David Baud[SUP] #[/SUP][SUP] 79 80 [/SUP], Alice Panchaud[SUP] #[/SUP][SUP] 81 82 [/SUP]
Affiliations
- PMID: 34230507
- DOI: 10.1038/s41598-021-92357-y
Abstract
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.