tetano
Editor, Senior Moderator
Sci Rep
. 2022 Dec 4;12(1):20943.
doi: 10.1038/s41598-022-24941-9.
Impaired pulmonary and muscle function during moderate exercise in female patients recovered from SARS-CoV-2
Eulogio Pleguezuelos[SUP] 1 2 [/SUP], Amin Del Carmen[SUP] 1 [/SUP], Eva Moreno[SUP] 3 [/SUP], Pilar Ortega[SUP] 4 [/SUP], Alejandro Robles[SUP] 4 [/SUP], Mateo Serra-Prat[SUP] 5 [/SUP], Marc Miravitlles[SUP] 6 [/SUP], Joan Carles Yebenes[SUP] 7 [/SUP], Manuel V Garnacho-Castaño[SUP] 8 [/SUP]
Affiliations
Abstract
This study aimed to assess pulmonary and muscle dysfunction by analyzing the slow component of oxygen uptake (VO[SUB]2SC[/SUB]), and mechanical and ventilatory efficiency in adult women recovered from the severe acute respiratory syndrome coronavirus type II (SARS-CoV-2) during a constant load test. 32 women (N = 17 patients with SARS-CoV-2; N = 15 control group) performed two cardiopulmonary exercise tests (CPX) on a cycle ergometer. In the first test, the participants performed incremental CPX until extenuation. In the second test the participants performed a 10-min CPX at a constant load intensity (watts) corresponding to the first ventilatory threshold. There was a 48-72 h rest period between the two tests. There was a significant increase in the VO[SUB]2SC[/SUB] in the patients recovered from SARS-CoV-2 (160.4 ± 60 mL min[SUP]-1[/SUP]) in comparison with the healthy participants (59.6 ± 65 mL min[SUP]-1[/SUP]) (P < 0.001). Mechanical efficiency significantly decreased in patients recovered from SARS-CoV-2 compared to the control group (P = 0.04). Ventilatory inefficiency significantly increased in the patients recovered from SARS-CoV-2 compared with the control group (P < 0.001). Adult women recovered from SARS-CoV-2 infection have important pulmonary and muscular dysfunction and fatigue which contributes to increasing the VO[SUB]2SC[/SUB] and reducing mechanical and ventilatory efficiency during mild-moderate exercise at a constant load.
. 2022 Dec 4;12(1):20943.
doi: 10.1038/s41598-022-24941-9.
Impaired pulmonary and muscle function during moderate exercise in female patients recovered from SARS-CoV-2
Eulogio Pleguezuelos[SUP] 1 2 [/SUP], Amin Del Carmen[SUP] 1 [/SUP], Eva Moreno[SUP] 3 [/SUP], Pilar Ortega[SUP] 4 [/SUP], Alejandro Robles[SUP] 4 [/SUP], Mateo Serra-Prat[SUP] 5 [/SUP], Marc Miravitlles[SUP] 6 [/SUP], Joan Carles Yebenes[SUP] 7 [/SUP], Manuel V Garnacho-Castaño[SUP] 8 [/SUP]
Affiliations
- PMID: 36464697
- DOI: 10.1038/s41598-022-24941-9
Abstract
This study aimed to assess pulmonary and muscle dysfunction by analyzing the slow component of oxygen uptake (VO[SUB]2SC[/SUB]), and mechanical and ventilatory efficiency in adult women recovered from the severe acute respiratory syndrome coronavirus type II (SARS-CoV-2) during a constant load test. 32 women (N = 17 patients with SARS-CoV-2; N = 15 control group) performed two cardiopulmonary exercise tests (CPX) on a cycle ergometer. In the first test, the participants performed incremental CPX until extenuation. In the second test the participants performed a 10-min CPX at a constant load intensity (watts) corresponding to the first ventilatory threshold. There was a 48-72 h rest period between the two tests. There was a significant increase in the VO[SUB]2SC[/SUB] in the patients recovered from SARS-CoV-2 (160.4 ± 60 mL min[SUP]-1[/SUP]) in comparison with the healthy participants (59.6 ± 65 mL min[SUP]-1[/SUP]) (P < 0.001). Mechanical efficiency significantly decreased in patients recovered from SARS-CoV-2 compared to the control group (P = 0.04). Ventilatory inefficiency significantly increased in the patients recovered from SARS-CoV-2 compared with the control group (P < 0.001). Adult women recovered from SARS-CoV-2 infection have important pulmonary and muscular dysfunction and fatigue which contributes to increasing the VO[SUB]2SC[/SUB] and reducing mechanical and ventilatory efficiency during mild-moderate exercise at a constant load.