tetano
Editor, Senior Moderator
Sci Rep
. 2022 May 12;12(1):7880.
doi: 10.1038/s41598-022-11847-9.
Human-to-dog transmission of SARS-CoV-2, Colombia
Ricardo Rivero[SUP] 1 [/SUP], Evelin Garay[SUP] 1 [/SUP], Yesica Botero[SUP] 1 [/SUP], Héctor Serrano-Coll[SUP] 1 [/SUP], Bertha Gastelbondo[SUP] 1 [/SUP], Marina Muñoz[SUP] 2 [/SUP], Nathalia Ballesteros[SUP] 2 [/SUP], Sergio Castañeda[SUP] 2 [/SUP], Luz Helena Patiño[SUP] 2 [/SUP], Juan David Ramirez[SUP] 2 [/SUP], Alfonso Calderon[SUP] 1 [/SUP], Camilo Guzmán[SUP] 1 [/SUP], Caty Martinez-Bravo[SUP] 1 [/SUP], Ader Aleman[SUP] 1 [/SUP], Germán Arrieta[SUP] 1 3 [/SUP], Salim Mattar[SUP] 4 5 [/SUP]
Affiliations
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has evolved to have a wide range of hosts, including non-human primates, wild and domestic animals. The ACE2 protein has a high level of conservation and is the common receptor invertebrate species for a viral infection to occur; this receptor could give rise to anthroponotic events. This article describes the first event of symptomatic transmission in Latin America from a human to a dog by the B.1.625 lineage of SARS-CoV-2. We found 21 shared mutations in the complete genomes of viral sequences from owners and dogs. Further phylogenetic and molecular analysis showed that 100% co-localization of the clade helps to understand human-animal transmission. Prediction of the Spike protein structure of the sequenced virus and docking analyzes showed that the E484K mutation in the receptor-binding domain (RBD) could contribute to the viral affinity of dACE2. Therefore, close contact between SARS-CoV-2-infected humans and pets should be avoided to prevent the emergence of novel mutations of public health importance from anthroponotic events.
. 2022 May 12;12(1):7880.
doi: 10.1038/s41598-022-11847-9.
Human-to-dog transmission of SARS-CoV-2, Colombia
Ricardo Rivero[SUP] 1 [/SUP], Evelin Garay[SUP] 1 [/SUP], Yesica Botero[SUP] 1 [/SUP], Héctor Serrano-Coll[SUP] 1 [/SUP], Bertha Gastelbondo[SUP] 1 [/SUP], Marina Muñoz[SUP] 2 [/SUP], Nathalia Ballesteros[SUP] 2 [/SUP], Sergio Castañeda[SUP] 2 [/SUP], Luz Helena Patiño[SUP] 2 [/SUP], Juan David Ramirez[SUP] 2 [/SUP], Alfonso Calderon[SUP] 1 [/SUP], Camilo Guzmán[SUP] 1 [/SUP], Caty Martinez-Bravo[SUP] 1 [/SUP], Ader Aleman[SUP] 1 [/SUP], Germán Arrieta[SUP] 1 3 [/SUP], Salim Mattar[SUP] 4 5 [/SUP]
Affiliations
- PMID: 35551247
- DOI: 10.1038/s41598-022-11847-9
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has evolved to have a wide range of hosts, including non-human primates, wild and domestic animals. The ACE2 protein has a high level of conservation and is the common receptor invertebrate species for a viral infection to occur; this receptor could give rise to anthroponotic events. This article describes the first event of symptomatic transmission in Latin America from a human to a dog by the B.1.625 lineage of SARS-CoV-2. We found 21 shared mutations in the complete genomes of viral sequences from owners and dogs. Further phylogenetic and molecular analysis showed that 100% co-localization of the clade helps to understand human-animal transmission. Prediction of the Spike protein structure of the sequenced virus and docking analyzes showed that the E484K mutation in the receptor-binding domain (RBD) could contribute to the viral affinity of dACE2. Therefore, close contact between SARS-CoV-2-infected humans and pets should be avoided to prevent the emergence of novel mutations of public health importance from anthroponotic events.