tetano
Editor, Senior Moderator
Sci Rep
. 2024 Dec 3;14(1):30021.
doi: 10.1038/s41598-024-81099-2. COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study
Carmen Infante-Domínguez[SUP] 1 2 [/SUP], Sonsoles Salto-Alejandre[SUP] 1 2 [/SUP], Rocío Álvarez-Marín[SUP] 1 2 [/SUP], Nuria Sabé[SUP] 2 3 [/SUP], Antonio Ramos-Martínez[SUP] 4 [/SUP], Asunción Moreno[SUP] 5 [/SUP], Kamilla Ferreira de Moraes[SUP] 6 [/SUP], Zaira R Palacios-Baena[SUP] 2 7 [/SUP], Patricia Muñoz[SUP] 8 [/SUP], Mario Fernández-Ruiz[SUP] 2 9 [/SUP], Marino Blanes[SUP] 10 [/SUP], Carmen Fariñas[SUP] 2 11 [/SUP], Elisa Vidal[SUP] 2 12 [/SUP], Esperanza Merino de Lucas[SUP] 13 14 [/SUP], Márcia Halpern[SUP] 15 [/SUP], Román Hernández-Gallego[SUP] 16 [/SUP], Matteo Bassetti[SUP] 17 [/SUP], Alessandra Mularoni[SUP] 18 [/SUP], Alex Gutiérrez-Dalmau[SUP] 19 [/SUP], Matteo Rinaldi[SUP] 20 21 [/SUP], Silvia Jiménez-Jorge[SUP] 22 [/SUP], Marta Bodro[SUP] 5 [/SUP], Luis Fernando Aranha-Camargo[SUP] 6 [/SUP], Maricela Valerio[SUP] 8 [/SUP], Javier Sánchez-Céspedes[SUP] 1 2 [/SUP], Belén Gutiérrez-Gutiérrez[SUP] 2 7 23 [/SUP], Maddalena Giannella[SUP] 20 21 [/SUP], Jesús Rodríguez-Baño[SUP] 2 7 23 [/SUP], Jerónimo Pachón[SUP] 24 25 [/SUP], Elisa Cordero[SUP] 1 2 23 [/SUP]; COVIDSOT, ORCHESTRA Working Teams
Collaborators, Affiliations
Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51-69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO[SUB]2[/SUB] < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.
Keywords: COVID-19; Clinical phenotypes; Mortality; Multicenter cohort study; Solid organ transplant recipients.
. 2024 Dec 3;14(1):30021.
doi: 10.1038/s41598-024-81099-2. COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study
Carmen Infante-Domínguez[SUP] 1 2 [/SUP], Sonsoles Salto-Alejandre[SUP] 1 2 [/SUP], Rocío Álvarez-Marín[SUP] 1 2 [/SUP], Nuria Sabé[SUP] 2 3 [/SUP], Antonio Ramos-Martínez[SUP] 4 [/SUP], Asunción Moreno[SUP] 5 [/SUP], Kamilla Ferreira de Moraes[SUP] 6 [/SUP], Zaira R Palacios-Baena[SUP] 2 7 [/SUP], Patricia Muñoz[SUP] 8 [/SUP], Mario Fernández-Ruiz[SUP] 2 9 [/SUP], Marino Blanes[SUP] 10 [/SUP], Carmen Fariñas[SUP] 2 11 [/SUP], Elisa Vidal[SUP] 2 12 [/SUP], Esperanza Merino de Lucas[SUP] 13 14 [/SUP], Márcia Halpern[SUP] 15 [/SUP], Román Hernández-Gallego[SUP] 16 [/SUP], Matteo Bassetti[SUP] 17 [/SUP], Alessandra Mularoni[SUP] 18 [/SUP], Alex Gutiérrez-Dalmau[SUP] 19 [/SUP], Matteo Rinaldi[SUP] 20 21 [/SUP], Silvia Jiménez-Jorge[SUP] 22 [/SUP], Marta Bodro[SUP] 5 [/SUP], Luis Fernando Aranha-Camargo[SUP] 6 [/SUP], Maricela Valerio[SUP] 8 [/SUP], Javier Sánchez-Céspedes[SUP] 1 2 [/SUP], Belén Gutiérrez-Gutiérrez[SUP] 2 7 23 [/SUP], Maddalena Giannella[SUP] 20 21 [/SUP], Jesús Rodríguez-Baño[SUP] 2 7 23 [/SUP], Jerónimo Pachón[SUP] 24 25 [/SUP], Elisa Cordero[SUP] 1 2 23 [/SUP]; COVIDSOT, ORCHESTRA Working Teams
Collaborators, Affiliations
- PMID: 39622951
- DOI: 10.1038/s41598-024-81099-2
Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51-69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO[SUB]2[/SUB] < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.
Keywords: COVID-19; Clinical phenotypes; Mortality; Multicenter cohort study; Solid organ transplant recipients.