tetano
Editor, Senior Moderator
Sci Rep
. 2020 Nov 30;10(1):20834.
doi: 10.1038/s41598-020-77641-7.
Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facility
Enrico Maria Trecarichi[SUP] 1 [/SUP], Maria Mazzitelli[SUP] 2 [/SUP], Francesca Serapide[SUP] 2 [/SUP], Maria Chiara Pelle[SUP] 2 [/SUP], Bruno Tassone[SUP] 2 [/SUP], Eugenio Arrighi[SUP] 2 [/SUP], Graziella Perri[SUP] 2 [/SUP], Paolo Fusco[SUP] 2 [/SUP], Vincenzo Scaglione[SUP] 2 [/SUP], Chiara Davoli[SUP] 2 [/SUP], Rosaria Lionello[SUP] 2 [/SUP], Valentina La Gamba[SUP] 2 [/SUP], Giuseppina Marrazzo[SUP] 3 [/SUP], Maria Teresa Busceti[SUP] 3 [/SUP], Amerigo Giudice[SUP] 4 [/SUP], Marco Ricchio[SUP] 2 [/SUP], Anna Cancelliere[SUP] 2 [/SUP], Elena Lio[SUP] 2 [/SUP], Giada Procopio[SUP] 2 [/SUP], Francesco Saverio Costanzo[SUP] 5 6 [/SUP], Daniela Patrizia Foti[SUP] 7 [/SUP], Giovanni Matera[SUP] 8 [/SUP], Carlo Torti[SUP] 2 [/SUP], IDTM UMG COVID-19 Group
Collaborators, Affiliations
Abstract
Since December 2019, coronavirus disease 2019 (COVID-19) pandemic has spread from China all over the world and many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection in a LTCF. A total of 50 patients were included. Mean age was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males. The overall in-hospital mortality rate was 32%. At Cox regression analysis, significant predictors of in-hospital mortality were: hypernatremia (HR 9.12), lymphocyte count < 1000 cells/?L (HR 7.45), cardiovascular diseases other than hypertension (HR 6.41), and higher levels of serum interleukin-6 (IL-6, pg/mL) (HR 1.005). Our study shows a high in-hospital mortality rate in a cohort of elderly patients with COVID-19 and hypernatremia, lymphopenia, CVD other than hypertension, and higher IL-6 serum levels were identified as independent predictors of in-hospital mortality. Given the small population size as major limitation of our study, further investigations are necessary to better understand and confirm our findings in elderly patients.
. 2020 Nov 30;10(1):20834.
doi: 10.1038/s41598-020-77641-7.
Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facility
Enrico Maria Trecarichi[SUP] 1 [/SUP], Maria Mazzitelli[SUP] 2 [/SUP], Francesca Serapide[SUP] 2 [/SUP], Maria Chiara Pelle[SUP] 2 [/SUP], Bruno Tassone[SUP] 2 [/SUP], Eugenio Arrighi[SUP] 2 [/SUP], Graziella Perri[SUP] 2 [/SUP], Paolo Fusco[SUP] 2 [/SUP], Vincenzo Scaglione[SUP] 2 [/SUP], Chiara Davoli[SUP] 2 [/SUP], Rosaria Lionello[SUP] 2 [/SUP], Valentina La Gamba[SUP] 2 [/SUP], Giuseppina Marrazzo[SUP] 3 [/SUP], Maria Teresa Busceti[SUP] 3 [/SUP], Amerigo Giudice[SUP] 4 [/SUP], Marco Ricchio[SUP] 2 [/SUP], Anna Cancelliere[SUP] 2 [/SUP], Elena Lio[SUP] 2 [/SUP], Giada Procopio[SUP] 2 [/SUP], Francesco Saverio Costanzo[SUP] 5 6 [/SUP], Daniela Patrizia Foti[SUP] 7 [/SUP], Giovanni Matera[SUP] 8 [/SUP], Carlo Torti[SUP] 2 [/SUP], IDTM UMG COVID-19 Group
Collaborators, Affiliations
- PMID: 33257703
- DOI: 10.1038/s41598-020-77641-7
Abstract
Since December 2019, coronavirus disease 2019 (COVID-19) pandemic has spread from China all over the world and many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection in a LTCF. A total of 50 patients were included. Mean age was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males. The overall in-hospital mortality rate was 32%. At Cox regression analysis, significant predictors of in-hospital mortality were: hypernatremia (HR 9.12), lymphocyte count < 1000 cells/?L (HR 7.45), cardiovascular diseases other than hypertension (HR 6.41), and higher levels of serum interleukin-6 (IL-6, pg/mL) (HR 1.005). Our study shows a high in-hospital mortality rate in a cohort of elderly patients with COVID-19 and hypernatremia, lymphopenia, CVD other than hypertension, and higher IL-6 serum levels were identified as independent predictors of in-hospital mortality. Given the small population size as major limitation of our study, further investigations are necessary to better understand and confirm our findings in elderly patients.